Comparison of laser and ozone treatments on oral mucositis in an experimental model
Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospital...
Gespeichert in:
| Veröffentlicht in: | Lasers in medical science 2017-04, Vol.32 (3), p.673-677 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 677 |
|---|---|
| container_issue | 3 |
| container_start_page | 673 |
| container_title | Lasers in medical science |
| container_volume | 32 |
| creator | Bayer, Suzan Kazancioglu, Hakki Oguz Acar, Ahmet Hüseyin Demirtas, Nihat Kandas, Nur Ozten |
| description | Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-β), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-β, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required. |
| doi_str_mv | 10.1007/s10103-017-2166-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1893882870</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4321050307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-5c770cddf4493dcdacb90fe655cc6b61e394634bed9f6782e64ebaf98cc0555d3</originalsourceid><addsrcrecordid>eNqN0UFrFTEQB_AgFfv69AN4KYFevKxmskk2Ocqj1ULBgwreQjaZlX3sbl6TXah-erO8ZymC0FMO85sZMn9C3gJ7D4w1HzIwYHXFoKk4KFXBC7IBUctKMfHjjGwYV7rShsM5uch5zwpUUL8i51yDYQB8Q77u4nhwqc9xorGjg8uYqJsCjb_jhHRO6OYRpznTFSQ30HHxMfdzn2k_FUnx4YCpX81ajAGH1-Rl54aMb07vlny_uf62-1zdffl0u_t4V3nJxFxJ3zTMh9AJYergg_OtYR0qKb1XrQKsjVC1aDGYTjWaoxLYus5o75mUMtRb8u4495Di_YJ5tmOfPQ6DmzAu2YI2tdZcN-wZVGsjjRBNoVf_0H1c0lQ-UlRjREHAi4Kj8inmnLCzh3IEl35ZYHYNxx7DseXmdg3HQum5PE1e2hHDY8ffNArgR5BLafqJ6cnq_079A298mcU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1879494412</pqid></control><display><type>article</type><title>Comparison of laser and ozone treatments on oral mucositis in an experimental model</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Bayer, Suzan ; Kazancioglu, Hakki Oguz ; Acar, Ahmet Hüseyin ; Demirtas, Nihat ; Kandas, Nur Ozten</creator><creatorcontrib>Bayer, Suzan ; Kazancioglu, Hakki Oguz ; Acar, Ahmet Hüseyin ; Demirtas, Nihat ; Kandas, Nur Ozten</creatorcontrib><description>Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-β), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-β, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-017-2166-1</identifier><identifier>PMID: 28190112</identifier><identifier>CODEN: LMSCEZ</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Animals ; Chemotherapy ; Clinical outcomes ; Comparative studies ; Dentistry ; Disease Models, Animal ; Growth factors ; Inflammation ; Lasers ; Low-Level Light Therapy ; Male ; Medical science ; Medical services ; Medical treatment ; Medicine ; Medicine & Public Health ; Mouth ; Optical Devices ; Optics ; Oral diseases ; Original Article ; Ozone ; Ozone - therapeutic use ; Photonics ; Quantum Optics ; Rats, Sprague-Dawley ; Receiving ; Stomatitis - drug therapy ; Stomatitis - radiotherapy ; Wound Healing - radiation effects</subject><ispartof>Lasers in medical science, 2017-04, Vol.32 (3), p.673-677</ispartof><rights>Springer-Verlag London 2017</rights><rights>Lasers in Medical Science is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-5c770cddf4493dcdacb90fe655cc6b61e394634bed9f6782e64ebaf98cc0555d3</citedby><cites>FETCH-LOGICAL-c504t-5c770cddf4493dcdacb90fe655cc6b61e394634bed9f6782e64ebaf98cc0555d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-017-2166-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-017-2166-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28190112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bayer, Suzan</creatorcontrib><creatorcontrib>Kazancioglu, Hakki Oguz</creatorcontrib><creatorcontrib>Acar, Ahmet Hüseyin</creatorcontrib><creatorcontrib>Demirtas, Nihat</creatorcontrib><creatorcontrib>Kandas, Nur Ozten</creatorcontrib><title>Comparison of laser and ozone treatments on oral mucositis in an experimental model</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-β), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-β, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required.</description><subject>Animals</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Comparative studies</subject><subject>Dentistry</subject><subject>Disease Models, Animal</subject><subject>Growth factors</subject><subject>Inflammation</subject><subject>Lasers</subject><subject>Low-Level Light Therapy</subject><subject>Male</subject><subject>Medical science</subject><subject>Medical services</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mouth</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Oral diseases</subject><subject>Original Article</subject><subject>Ozone</subject><subject>Ozone - therapeutic use</subject><subject>Photonics</subject><subject>Quantum Optics</subject><subject>Rats, Sprague-Dawley</subject><subject>Receiving</subject><subject>Stomatitis - drug therapy</subject><subject>Stomatitis - radiotherapy</subject><subject>Wound Healing - radiation effects</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0UFrFTEQB_AgFfv69AN4KYFevKxmskk2Ocqj1ULBgwreQjaZlX3sbl6TXah-erO8ZymC0FMO85sZMn9C3gJ7D4w1HzIwYHXFoKk4KFXBC7IBUctKMfHjjGwYV7rShsM5uch5zwpUUL8i51yDYQB8Q77u4nhwqc9xorGjg8uYqJsCjb_jhHRO6OYRpznTFSQ30HHxMfdzn2k_FUnx4YCpX81ajAGH1-Rl54aMb07vlny_uf62-1zdffl0u_t4V3nJxFxJ3zTMh9AJYergg_OtYR0qKb1XrQKsjVC1aDGYTjWaoxLYus5o75mUMtRb8u4495Di_YJ5tmOfPQ6DmzAu2YI2tdZcN-wZVGsjjRBNoVf_0H1c0lQ-UlRjREHAi4Kj8inmnLCzh3IEl35ZYHYNxx7DseXmdg3HQum5PE1e2hHDY8ffNArgR5BLafqJ6cnq_079A298mcU</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Bayer, Suzan</creator><creator>Kazancioglu, Hakki Oguz</creator><creator>Acar, Ahmet Hüseyin</creator><creator>Demirtas, Nihat</creator><creator>Kandas, Nur Ozten</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170401</creationdate><title>Comparison of laser and ozone treatments on oral mucositis in an experimental model</title><author>Bayer, Suzan ; Kazancioglu, Hakki Oguz ; Acar, Ahmet Hüseyin ; Demirtas, Nihat ; Kandas, Nur Ozten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-5c770cddf4493dcdacb90fe655cc6b61e394634bed9f6782e64ebaf98cc0555d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Comparative studies</topic><topic>Dentistry</topic><topic>Disease Models, Animal</topic><topic>Growth factors</topic><topic>Inflammation</topic><topic>Lasers</topic><topic>Low-Level Light Therapy</topic><topic>Male</topic><topic>Medical science</topic><topic>Medical services</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mouth</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Oral diseases</topic><topic>Original Article</topic><topic>Ozone</topic><topic>Ozone - therapeutic use</topic><topic>Photonics</topic><topic>Quantum Optics</topic><topic>Rats, Sprague-Dawley</topic><topic>Receiving</topic><topic>Stomatitis - drug therapy</topic><topic>Stomatitis - radiotherapy</topic><topic>Wound Healing - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bayer, Suzan</creatorcontrib><creatorcontrib>Kazancioglu, Hakki Oguz</creatorcontrib><creatorcontrib>Acar, Ahmet Hüseyin</creatorcontrib><creatorcontrib>Demirtas, Nihat</creatorcontrib><creatorcontrib>Kandas, Nur Ozten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bayer, Suzan</au><au>Kazancioglu, Hakki Oguz</au><au>Acar, Ahmet Hüseyin</au><au>Demirtas, Nihat</au><au>Kandas, Nur Ozten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of laser and ozone treatments on oral mucositis in an experimental model</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>32</volume><issue>3</issue><spage>673</spage><epage>677</epage><pages>673-677</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><coden>LMSCEZ</coden><abstract>Oral mucositis (OM) induces severe pain and limits fundamental life behaviors such as eating, drinking, and talking for patients receiving chemotherapy or radiotherapy. In addition, through opportunistic microorganisms, OM frequently leads to systemic infection which then leads to prolonged hospitalization. Severe lesions often adversely affect curative effects in cancer cases. Therefore, the control of OM is important for oral health quality of life and prognosis. Low-level laser therapy (LLLT) and ozone may be useful to accelerate wound healing. In this study, 24 Sprague-Dawley rats were divided into three groups as control, ozone, and laser groups. All groups received 5-fluorouracil intraperitoneally and trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the ozone group was administered ozone, and the laser group, LLLT. Then, all groups were sacrificed and basic fibroblast growth factor (bFGF), transforming growth factor (TGF-β), and platelet-derived growth factor (PDGF) were evaluated in all groups. LLLT was determined to be statistically significantly more effective than ozone on FGF and PDGF. However, in respect of TGF-β, no statistically significant difference was observed between the groups. In conclusion, within the limitations of this study, LLLT is more effective than ozone. However, further studies on this subject are required.</abstract><cop>London</cop><pub>Springer London</pub><pmid>28190112</pmid><doi>10.1007/s10103-017-2166-1</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-8921 |
| ispartof | Lasers in medical science, 2017-04, Vol.32 (3), p.673-677 |
| issn | 0268-8921 1435-604X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893882870 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Chemotherapy Clinical outcomes Comparative studies Dentistry Disease Models, Animal Growth factors Inflammation Lasers Low-Level Light Therapy Male Medical science Medical services Medical treatment Medicine Medicine & Public Health Mouth Optical Devices Optics Oral diseases Original Article Ozone Ozone - therapeutic use Photonics Quantum Optics Rats, Sprague-Dawley Receiving Stomatitis - drug therapy Stomatitis - radiotherapy Wound Healing - radiation effects |
| title | Comparison of laser and ozone treatments on oral mucositis in an experimental model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T00%3A10%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20laser%20and%20ozone%20treatments%20on%20oral%20mucositis%20in%20an%20experimental%20model&rft.jtitle=Lasers%20in%20medical%20science&rft.au=Bayer,%20Suzan&rft.date=2017-04-01&rft.volume=32&rft.issue=3&rft.spage=673&rft.epage=677&rft.pages=673-677&rft.issn=0268-8921&rft.eissn=1435-604X&rft.coden=LMSCEZ&rft_id=info:doi/10.1007/s10103-017-2166-1&rft_dat=%3Cproquest_cross%3E4321050307%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1879494412&rft_id=info:pmid/28190112&rfr_iscdi=true |