Comparison of Soluble Decoy IgG Fusion Proteins of BAFF-R and BCMA as Antagonists for BAFF

BAFF is considered a therapeutic target because dysregulated production of BAFF can induce systemic lupus erythematosus-like phenotype in mice, and elevated levels of BAFF are associated with disease severity in systemic lupus erythematosus and rheumatoid arthritis patients. Fc fusion decoy receptor...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (35), p.33127-33133
Hauptverfasser:	Pelletier, Marc, Thompson, Jeffrey S., Qian, Fang, Bixler, Sarah A., Gong, Dahai, Cachero, Teresa, Gilbride, Kevin, Day, Eric, Zafari, Mohammad, Benjamin, Chris, Gorelik, Leonid, Whitty, Adrian, Kalled, Susan L., Ambrose, Christine, Hsu, Yen-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - metabolism Asparagine - chemistry B-Cell Activating Factor B-Cell Activation Factor Receptor B-Cell Maturation Antigen B-Lymphocytes - metabolism BAFF protein Cell Membrane - metabolism Cell Separation Cell Survival CHO Cells Cricetinae Dimerization Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Flow Cytometry Immunoglobulin G - chemistry Leucine - chemistry Lupus Erythematosus, Systemic - metabolism Membrane Proteins - chemistry Mice Mice, Inbred BALB C Mice, Inbred C57BL Phenotype Proline - chemistry Protein Binding Receptors, Tumor Necrosis Factor - chemistry Recombinant Fusion Proteins - metabolism Spleen - cytology Tumor Necrosis Factor-alpha - chemistry Valine - chemistry
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