Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands

G protein‐coupled receptors (GPCRs) play an important role in many cellular responses; as such, their mechanism of action is of utmost interest. To gain insight into the active conformation of GPCRs, the X‐ray crystal structures of nanobody (Nb)‐stabilized β2‐adrenergic receptor (β2AR) have been rep...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemistry : a European journal 2017-07, Vol.23 (40), p.9632-9640
Hauptverfasser:	Martin, Charlotte, Moors, Samuel L. C., Danielsen, Mia, Betti, Cecilia, Fabris, Cecilia, Sejer Pedersen, Daniel, Pardon, Els, Peyressatre, Marion, Fehér, Krisztina, Martins, José C., Mosolff Mathiesen, Jesper, Morris, May C., Devoogdt, Nick, Caveliers, Vicky, De Proft, Frank, Steyaert, Jan, Ballet, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Chemistry Complementarity-determining region 3 Conformational analysis Crystal structure Crystallography G protein-coupled receptors Internalization Intracellular Nanobodies Peptidomimetics protein structures Proteins protein–protein interactions Receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!