Evaluation of real‐life dosing of oral medicines with respect to fluid and food intake in a Dutch‐speaking population
Summary What is known and objective Oral drug administration is the most preferred route of drug administration. For some specific classes of drugs, recommendations regarding the intake of the drug product are provided by and approved in the summary of product characteristics (SmPC) after testing th...
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| Veröffentlicht in: | Journal of clinical pharmacy and therapeutics 2017-08, Vol.42 (4), p.467-474 |
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| container_title | Journal of clinical pharmacy and therapeutics |
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| creator | Hens, B. Van Den Abeele, J. Rubbens, J. Keirsebilck, M. Roelens, J. Schreurs, C. Verheyen, K. Casteels, M. Laekeman, G. Augustijns, P. |
| description | Summary
What is known and objective
Oral drug administration is the most preferred route of drug administration. For some specific classes of drugs, recommendations regarding the intake of the drug product are provided by and approved in the summary of product characteristics (SmPC) after testing the oral drug product in clinical trials under strict and predefined conditions. The aim of this study was to investigate how certain classes of medicines are taken in a “real‐life” setting in terms of concomitant fluid and food intake by a Dutch‐speaking population in Flanders (Belgium). The outcome of this study was comprehensively discussed with literature data to evaluate the positive or negative consequences of their drug intake in daily life.
Methods
A retrospective and non‐interventional study was set up by means of questionnaires completed by two different groups: children (ie 0‐15 years) and (young) adults (ie 16 years and older).
Results and discussion
In children, the co‐administered volume increases with age because of a gradual switch from liquids to solid dosage forms. In adults, water was the most selected co‐administered fluid and the preferred volume of intake was a half glass of liquid.
What is new and conclusion
Results of the surveys clearly indicated that the majority of all participants took their medication with a sip or half glass of water. However, this was not the case for the youngest children, as their preferred formulations were liquids (eg solutions, suspensions) which do not require any extra intake of liquid. In the case of specific classes of drugs, real‐life intake can still be improved, suggesting that the pharmacist's advice has an important influence on their administration of medicines.
This work aimed to evaluate how Dutch‐speaking patients (subdivided between children and adults) in Flanders (Belgium) took their oral medicines in a real‐life setting with respect to fluid and food intake. |
| doi_str_mv | 10.1111/jcpt.12535 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1893553297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1916974093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4195-2facb133fb21ad14162a8544713f742543e5055b7e444ef6d9d604cd4bbf1d9e3</originalsourceid><addsrcrecordid>eNp9kbtOHDEUhq0oUdiQNHmAyBINirTEx5fxukQbSEBIpCC15fElePGOh_FM0HZ5BJ4xTxIvCxQUOc0vHX36fPkR-gjkCOp8Wdl-PAIqmHiFZsAaMacSyGs0I7RRcy6p3EPvSlkRQhpJ2Vu0RxdcUNLADG1Ofps0mTHmDueAB2_S3z_3KQaPXS6x-7Xd5sEkvPYu2tj5gu_ieF3J0ns74jHjkKbosOkcDjk7HLvR3Pga2OCv02ivq7Cy5mZr63M_pYfj3qM3waTiPzzmPvp5enK1_D6_uPx2tjy-mFsOqj4lGNsCY6GlYBxwaKhZCM4lsCA5FZx5QYRopeec-9A45RrCreNtG8Apz_bR4c7bD_l28mXU61isT8l0Pk9Fw0IxIRhVsqIHL9BVnoau3k6DgkZJThSr1OcdZYdcyuCD7oe4NsNGA9HbQvS2EP1QSIU_PSqntv7gM_rUQAVgB9zF5Df_Uenz5Y-rnfQfHhWYDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1916974093</pqid></control><display><type>article</type><title>Evaluation of real‐life dosing of oral medicines with respect to fluid and food intake in a Dutch‐speaking population</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hens, B. ; Van Den Abeele, J. ; Rubbens, J. ; Keirsebilck, M. ; Roelens, J. ; Schreurs, C. ; Verheyen, K. ; Casteels, M. ; Laekeman, G. ; Augustijns, P.</creator><creatorcontrib>Hens, B. ; Van Den Abeele, J. ; Rubbens, J. ; Keirsebilck, M. ; Roelens, J. ; Schreurs, C. ; Verheyen, K. ; Casteels, M. ; Laekeman, G. ; Augustijns, P.</creatorcontrib><description>Summary
What is known and objective
Oral drug administration is the most preferred route of drug administration. For some specific classes of drugs, recommendations regarding the intake of the drug product are provided by and approved in the summary of product characteristics (SmPC) after testing the oral drug product in clinical trials under strict and predefined conditions. The aim of this study was to investigate how certain classes of medicines are taken in a “real‐life” setting in terms of concomitant fluid and food intake by a Dutch‐speaking population in Flanders (Belgium). The outcome of this study was comprehensively discussed with literature data to evaluate the positive or negative consequences of their drug intake in daily life.
Methods
A retrospective and non‐interventional study was set up by means of questionnaires completed by two different groups: children (ie 0‐15 years) and (young) adults (ie 16 years and older).
Results and discussion
In children, the co‐administered volume increases with age because of a gradual switch from liquids to solid dosage forms. In adults, water was the most selected co‐administered fluid and the preferred volume of intake was a half glass of liquid.
What is new and conclusion
Results of the surveys clearly indicated that the majority of all participants took their medication with a sip or half glass of water. However, this was not the case for the youngest children, as their preferred formulations were liquids (eg solutions, suspensions) which do not require any extra intake of liquid. In the case of specific classes of drugs, real‐life intake can still be improved, suggesting that the pharmacist's advice has an important influence on their administration of medicines.
This work aimed to evaluate how Dutch‐speaking patients (subdivided between children and adults) in Flanders (Belgium) took their oral medicines in a real‐life setting with respect to fluid and food intake.</description><identifier>ISSN: 0269-4727</identifier><identifier>EISSN: 1365-2710</identifier><identifier>DOI: 10.1111/jcpt.12535</identifier><identifier>PMID: 28452061</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Administration, Oral ; Adolescent ; Adult ; Age Factors ; Belgium ; bioavailability ; Child ; Child, Preschool ; Children ; clinical pharmacokinetics ; clinical pharmacy ; Clinical trials ; Drinking ; drug absorption ; drug interactions ; Eating ; Female ; Food intake ; Formulations ; Humans ; Infant ; Infant, Newborn ; Male ; medicine use ; non‐steroidal anti‐inflammatory drugs ; omeprazole ; Patient Education as Topic - methods ; Pharmaceutical Preparations - administration & dosage ; Pharmacists - organization & administration ; pharmacokinetics ; Retrospective Studies ; statin ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Journal of clinical pharmacy and therapeutics, 2017-08, Vol.42 (4), p.467-474</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4195-2facb133fb21ad14162a8544713f742543e5055b7e444ef6d9d604cd4bbf1d9e3</citedby><cites>FETCH-LOGICAL-c4195-2facb133fb21ad14162a8544713f742543e5055b7e444ef6d9d604cd4bbf1d9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpt.12535$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpt.12535$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28452061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hens, B.</creatorcontrib><creatorcontrib>Van Den Abeele, J.</creatorcontrib><creatorcontrib>Rubbens, J.</creatorcontrib><creatorcontrib>Keirsebilck, M.</creatorcontrib><creatorcontrib>Roelens, J.</creatorcontrib><creatorcontrib>Schreurs, C.</creatorcontrib><creatorcontrib>Verheyen, K.</creatorcontrib><creatorcontrib>Casteels, M.</creatorcontrib><creatorcontrib>Laekeman, G.</creatorcontrib><creatorcontrib>Augustijns, P.</creatorcontrib><title>Evaluation of real‐life dosing of oral medicines with respect to fluid and food intake in a Dutch‐speaking population</title><title>Journal of clinical pharmacy and therapeutics</title><addtitle>J Clin Pharm Ther</addtitle><description>Summary
What is known and objective
Oral drug administration is the most preferred route of drug administration. For some specific classes of drugs, recommendations regarding the intake of the drug product are provided by and approved in the summary of product characteristics (SmPC) after testing the oral drug product in clinical trials under strict and predefined conditions. The aim of this study was to investigate how certain classes of medicines are taken in a “real‐life” setting in terms of concomitant fluid and food intake by a Dutch‐speaking population in Flanders (Belgium). The outcome of this study was comprehensively discussed with literature data to evaluate the positive or negative consequences of their drug intake in daily life.
Methods
A retrospective and non‐interventional study was set up by means of questionnaires completed by two different groups: children (ie 0‐15 years) and (young) adults (ie 16 years and older).
Results and discussion
In children, the co‐administered volume increases with age because of a gradual switch from liquids to solid dosage forms. In adults, water was the most selected co‐administered fluid and the preferred volume of intake was a half glass of liquid.
What is new and conclusion
Results of the surveys clearly indicated that the majority of all participants took their medication with a sip or half glass of water. However, this was not the case for the youngest children, as their preferred formulations were liquids (eg solutions, suspensions) which do not require any extra intake of liquid. In the case of specific classes of drugs, real‐life intake can still be improved, suggesting that the pharmacist's advice has an important influence on their administration of medicines.
This work aimed to evaluate how Dutch‐speaking patients (subdivided between children and adults) in Flanders (Belgium) took their oral medicines in a real‐life setting with respect to fluid and food intake.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Belgium</subject><subject>bioavailability</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>clinical pharmacokinetics</subject><subject>clinical pharmacy</subject><subject>Clinical trials</subject><subject>Drinking</subject><subject>drug absorption</subject><subject>drug interactions</subject><subject>Eating</subject><subject>Female</subject><subject>Food intake</subject><subject>Formulations</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>medicine use</subject><subject>non‐steroidal anti‐inflammatory drugs</subject><subject>omeprazole</subject><subject>Patient Education as Topic - methods</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmacists - organization & administration</subject><subject>pharmacokinetics</subject><subject>Retrospective Studies</subject><subject>statin</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>0269-4727</issn><issn>1365-2710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kbtOHDEUhq0oUdiQNHmAyBINirTEx5fxukQbSEBIpCC15fElePGOh_FM0HZ5BJ4xTxIvCxQUOc0vHX36fPkR-gjkCOp8Wdl-PAIqmHiFZsAaMacSyGs0I7RRcy6p3EPvSlkRQhpJ2Vu0RxdcUNLADG1Ofps0mTHmDueAB2_S3z_3KQaPXS6x-7Xd5sEkvPYu2tj5gu_ieF3J0ns74jHjkKbosOkcDjk7HLvR3Pga2OCv02ivq7Cy5mZr63M_pYfj3qM3waTiPzzmPvp5enK1_D6_uPx2tjy-mFsOqj4lGNsCY6GlYBxwaKhZCM4lsCA5FZx5QYRopeec-9A45RrCreNtG8Apz_bR4c7bD_l28mXU61isT8l0Pk9Fw0IxIRhVsqIHL9BVnoau3k6DgkZJThSr1OcdZYdcyuCD7oe4NsNGA9HbQvS2EP1QSIU_PSqntv7gM_rUQAVgB9zF5Df_Uenz5Y-rnfQfHhWYDg</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Hens, B.</creator><creator>Van Den Abeele, J.</creator><creator>Rubbens, J.</creator><creator>Keirsebilck, M.</creator><creator>Roelens, J.</creator><creator>Schreurs, C.</creator><creator>Verheyen, K.</creator><creator>Casteels, M.</creator><creator>Laekeman, G.</creator><creator>Augustijns, P.</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Evaluation of real‐life dosing of oral medicines with respect to fluid and food intake in a Dutch‐speaking population</title><author>Hens, B. ; Van Den Abeele, J. ; Rubbens, J. ; Keirsebilck, M. ; Roelens, J. ; Schreurs, C. ; Verheyen, K. ; Casteels, M. ; Laekeman, G. ; Augustijns, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4195-2facb133fb21ad14162a8544713f742543e5055b7e444ef6d9d604cd4bbf1d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Belgium</topic><topic>bioavailability</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>clinical pharmacokinetics</topic><topic>clinical pharmacy</topic><topic>Clinical trials</topic><topic>Drinking</topic><topic>drug absorption</topic><topic>drug interactions</topic><topic>Eating</topic><topic>Female</topic><topic>Food intake</topic><topic>Formulations</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>medicine use</topic><topic>non‐steroidal anti‐inflammatory drugs</topic><topic>omeprazole</topic><topic>Patient Education as Topic - methods</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmacists - organization & administration</topic><topic>pharmacokinetics</topic><topic>Retrospective Studies</topic><topic>statin</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hens, B.</creatorcontrib><creatorcontrib>Van Den Abeele, J.</creatorcontrib><creatorcontrib>Rubbens, J.</creatorcontrib><creatorcontrib>Keirsebilck, M.</creatorcontrib><creatorcontrib>Roelens, J.</creatorcontrib><creatorcontrib>Schreurs, C.</creatorcontrib><creatorcontrib>Verheyen, K.</creatorcontrib><creatorcontrib>Casteels, M.</creatorcontrib><creatorcontrib>Laekeman, G.</creatorcontrib><creatorcontrib>Augustijns, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacy and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hens, B.</au><au>Van Den Abeele, J.</au><au>Rubbens, J.</au><au>Keirsebilck, M.</au><au>Roelens, J.</au><au>Schreurs, C.</au><au>Verheyen, K.</au><au>Casteels, M.</au><au>Laekeman, G.</au><au>Augustijns, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of real‐life dosing of oral medicines with respect to fluid and food intake in a Dutch‐speaking population</atitle><jtitle>Journal of clinical pharmacy and therapeutics</jtitle><addtitle>J Clin Pharm Ther</addtitle><date>2017-08</date><risdate>2017</risdate><volume>42</volume><issue>4</issue><spage>467</spage><epage>474</epage><pages>467-474</pages><issn>0269-4727</issn><eissn>1365-2710</eissn><abstract>Summary
What is known and objective
Oral drug administration is the most preferred route of drug administration. For some specific classes of drugs, recommendations regarding the intake of the drug product are provided by and approved in the summary of product characteristics (SmPC) after testing the oral drug product in clinical trials under strict and predefined conditions. The aim of this study was to investigate how certain classes of medicines are taken in a “real‐life” setting in terms of concomitant fluid and food intake by a Dutch‐speaking population in Flanders (Belgium). The outcome of this study was comprehensively discussed with literature data to evaluate the positive or negative consequences of their drug intake in daily life.
Methods
A retrospective and non‐interventional study was set up by means of questionnaires completed by two different groups: children (ie 0‐15 years) and (young) adults (ie 16 years and older).
Results and discussion
In children, the co‐administered volume increases with age because of a gradual switch from liquids to solid dosage forms. In adults, water was the most selected co‐administered fluid and the preferred volume of intake was a half glass of liquid.
What is new and conclusion
Results of the surveys clearly indicated that the majority of all participants took their medication with a sip or half glass of water. However, this was not the case for the youngest children, as their preferred formulations were liquids (eg solutions, suspensions) which do not require any extra intake of liquid. In the case of specific classes of drugs, real‐life intake can still be improved, suggesting that the pharmacist's advice has an important influence on their administration of medicines.
This work aimed to evaluate how Dutch‐speaking patients (subdivided between children and adults) in Flanders (Belgium) took their oral medicines in a real‐life setting with respect to fluid and food intake.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>28452061</pmid><doi>10.1111/jcpt.12535</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-4727 |
| ispartof | Journal of clinical pharmacy and therapeutics, 2017-08, Vol.42 (4), p.467-474 |
| issn | 0269-4727 1365-2710 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Administration, Oral Adolescent Adult Age Factors Belgium bioavailability Child Child, Preschool Children clinical pharmacokinetics clinical pharmacy Clinical trials Drinking drug absorption drug interactions Eating Female Food intake Formulations Humans Infant Infant, Newborn Male medicine use non‐steroidal anti‐inflammatory drugs omeprazole Patient Education as Topic - methods Pharmaceutical Preparations - administration & dosage Pharmacists - organization & administration pharmacokinetics Retrospective Studies statin Surveys and Questionnaires Young Adult |
| title | Evaluation of real‐life dosing of oral medicines with respect to fluid and food intake in a Dutch‐speaking population |
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