Local energy on demand: are ‘spontaneous’ astrocytic Ca2+ -microdomains the regulatory unit for astrocyte-neuron metabolic cooperation?

Highlights • Asynchronous Ca2+ and Na+ microdomains are observed in astrocytes. • The complex morphology of astrocytes spatially restricts diffusion and signaling. • Microdomains are proposed as regulatory units of metabolic neuron-glia interaction. • This regulation may involve small groups of syna...

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Veröffentlicht in:	Brain research bulletin 2018-01, Vol.136, p.54-64
Hauptverfasser:	Oheim, Martin, Schmidt, Elke, Hirrlinger, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain energy metabolism Calcium microdomain Functional compartmentation Neurology Peripheral astrocyte process (PAP) Tripartite synapse
Online-Zugang:	Volltext
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