Local energy on demand: are ‘spontaneous’ astrocytic Ca2+ -microdomains the regulatory unit for astrocyte-neuron metabolic cooperation?

Local energy on demand: are ‘spontaneous’ astrocytic Ca2+ -microdomains the regulatory unit for astrocyte-neuron metabolic cooperation?

Highlights • Asynchronous Ca2+ and Na+ microdomains are observed in astrocytes. • The complex morphology of astrocytes spatially restricts diffusion and signaling. • Microdomains are proposed as regulatory units of metabolic neuron-glia interaction. • This regulation may involve small groups of syna...

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Veröffentlicht in:Brain research bulletin 2018-01, Vol.136, p.54-64
Hauptverfasser: Oheim, Martin, Schmidt, Elke, Hirrlinger, Johannes
Format: Artikel
Sprache:eng
Schlagworte:
Brain energy metabolism
Calcium microdomain
Functional compartmentation
Neurology
Peripheral astrocyte process (PAP)
Tripartite synapse
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Zusammenfassung:Highlights • Asynchronous Ca2+ and Na+ microdomains are observed in astrocytes. • The complex morphology of astrocytes spatially restricts diffusion and signaling. • Microdomains are proposed as regulatory units of metabolic neuron-glia interaction. • This regulation may involve small groups of synapses or even single synapses.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2017.04.011