PKCι is a target of 7,8,4′‐trihydroxyisoflavone for the suppression of UVB‐induced MMP‐1 expression

The soy isoflavone daidzein is bioconverted to 7,8,4′‐trihydroxyisoflavone (7,8,4′‐THIF) by microorganisms. Here, we investigated the matrix metalloproteinase (MMP)‐1 inhibitory properties of 7,8,4′‐THIF that arise through the suppression of UVB‐induced MMP‐1 expression. 7,8,4′‐THIF reduced UVB‐indu...

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Veröffentlicht in:	Experimental dermatology 2018-05, Vol.27 (5), p.449-452
Hauptverfasser:	Lim, Tae‐Gyu, Kim, Yoon‐A, Kim, Jong‐Eun, Baek, Sohee, Lee, Sung‐Young, Lee, Charles C., Chen, Hanyong, Kim, Jong Rhan, Kwon, Jung Yeon, Bode, Ann M., Lee, Chang Yong, Dong, Zigang, Oh, Deok‐Kun, Park, Jun Seong, Lee, Ki Won
Format:	Artikel
Sprache:	eng
Schlagworte:	3D culture 7,8,4′‐trihydroxyisoflavone Bioconversion Daidzein Drug Evaluation, Preclinical Fibroblasts Fluorescence polarization Humans Isoenzymes - antagonists & inhibitors Isoflavones Isoflavones - pharmacology Kinases MAP kinase Matrix metalloproteinase Matrix Metalloproteinase 1 - metabolism matrix metalloproteinase‐1 Metal ions Metalloproteinase Protein kinase C Protein Kinase C - antagonists & inhibitors Protein kinase C iota Signal transduction Skin Skin Aging - drug effects Transcription Ultraviolet Rays
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