Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers
Abstract Background The role of chronic inflammation in mitral restenosis after percutaneous mitral commissurotomy (PMC) is still controversial. Aims We sought to assess the predictive value of inflammation and extracellular matrix (ECM) remodeling biomarkers in late mitral restenosis after PMC. Met...
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| Veröffentlicht in: | Heart & lung 2017-07, Vol.46 (4), p.258-264 |
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| creator | Mechmeche, Rachid, MD Zaroui, Amira, MD Aloui, Sonia, MD Boukhris, Marouane, MD Allal-Elasmi, Monia, MD Kaabachi, Naziha, MD Zouari, Bechir, MD |
| description | Abstract Background The role of chronic inflammation in mitral restenosis after percutaneous mitral commissurotomy (PMC) is still controversial. Aims We sought to assess the predictive value of inflammation and extracellular matrix (ECM) remodeling biomarkers in late mitral restenosis after PMC. Methods We prospectively enrolled 155 patients (mean age 46.2±11 years) with at least 5 year follow up after primary PMC. Serum levels of high sensitive C-Reactive Protein (hs-CRP), matrix metalloproteinases MMPs, tissue-specific inhibitors of matrix metalloproteinases TIMPs, and tumor necrosis factor α (TNFα)] were measured. Results Late mitral restenosis occurred in 55 patients (35.5%). The independent predictors of late mitral stenosis were: age> 55 years [HR10.51 (95%CI 1.12–95.9); p =0.037]; no long acting penicillin therapy [HR 18.1 (95% CI 2.6–122.9); p =0.003]; TNFα > 80 ng/ml [HR 5.85 (95% CI 1.1–31.42); p =0.039]; and TIMP-2 > 289 ng/ml [HR 0.52 (95% CI 0.22–0.95); p =0.045]. Conclusion Chronic inflammation and ECM remodeling are involved in late mitral restenosis after PMC. |
| doi_str_mv | 10.1016/j.hrtlng.2017.03.006 |
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Aims We sought to assess the predictive value of inflammation and extracellular matrix (ECM) remodeling biomarkers in late mitral restenosis after PMC. Methods We prospectively enrolled 155 patients (mean age 46.2±11 years) with at least 5 year follow up after primary PMC. Serum levels of high sensitive C-Reactive Protein (hs-CRP), matrix metalloproteinases MMPs, tissue-specific inhibitors of matrix metalloproteinases TIMPs, and tumor necrosis factor α (TNFα)] were measured. Results Late mitral restenosis occurred in 55 patients (35.5%). The independent predictors of late mitral stenosis were: age> 55 years [HR10.51 (95%CI 1.12–95.9); p =0.037]; no long acting penicillin therapy [HR 18.1 (95% CI 2.6–122.9); p =0.003]; TNFα > 80 ng/ml [HR 5.85 (95% CI 1.1–31.42); p =0.039]; and TIMP-2 > 289 ng/ml [HR 0.52 (95% CI 0.22–0.95); p =0.045]. Conclusion Chronic inflammation and ECM remodeling are involved in late mitral restenosis after PMC.</description><identifier>ISSN: 0147-9563</identifier><identifier>EISSN: 1527-3288</identifier><identifier>DOI: 10.1016/j.hrtlng.2017.03.006</identifier><identifier>PMID: 28450150</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Biomarkers - metabolism ; C-Reactive Protein - metabolism ; Cardiac Surgical Procedures - adverse effects ; Cardiovascular ; Chronic inflammation ; Critical Care ; Echocardiography ; Extracellular Matrix - metabolism ; Female ; Follow-Up Studies ; Humans ; Male ; Matrix metalloproteinases ; Middle Aged ; Mitral restenosis ; Mitral stenosis ; Mitral Valve - surgery ; Mitral Valve Stenosis - diagnosis ; Mitral Valve Stenosis - metabolism ; Mitral Valve Stenosis - surgery ; Percutaneous mitral commissurotomy ; Postoperative Complications ; Prospective Studies ; Pulmonary/Respiratory ; Recurrence ; Time Factors ; Tissue Inhibitor of Metalloproteinase-2 - metabolism ; TNFα</subject><ispartof>Heart & lung, 2017-07, Vol.46 (4), p.258-264</ispartof><rights>Elsevier Inc.</rights><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3770a5abf5447648f470b00237ace28777b11976b6535b0b41ddad00f86156163</citedby><cites>FETCH-LOGICAL-c417t-3770a5abf5447648f470b00237ace28777b11976b6535b0b41ddad00f86156163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.hrtlng.2017.03.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28450150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mechmeche, Rachid, MD</creatorcontrib><creatorcontrib>Zaroui, Amira, MD</creatorcontrib><creatorcontrib>Aloui, Sonia, MD</creatorcontrib><creatorcontrib>Boukhris, Marouane, MD</creatorcontrib><creatorcontrib>Allal-Elasmi, Monia, MD</creatorcontrib><creatorcontrib>Kaabachi, Naziha, MD</creatorcontrib><creatorcontrib>Zouari, Bechir, MD</creatorcontrib><title>Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers</title><title>Heart & lung</title><addtitle>Heart Lung</addtitle><description>Abstract Background The role of chronic inflammation in mitral restenosis after percutaneous mitral commissurotomy (PMC) is still controversial. Aims We sought to assess the predictive value of inflammation and extracellular matrix (ECM) remodeling biomarkers in late mitral restenosis after PMC. Methods We prospectively enrolled 155 patients (mean age 46.2±11 years) with at least 5 year follow up after primary PMC. Serum levels of high sensitive C-Reactive Protein (hs-CRP), matrix metalloproteinases MMPs, tissue-specific inhibitors of matrix metalloproteinases TIMPs, and tumor necrosis factor α (TNFα)] were measured. Results Late mitral restenosis occurred in 55 patients (35.5%). The independent predictors of late mitral stenosis were: age> 55 years [HR10.51 (95%CI 1.12–95.9); p =0.037]; no long acting penicillin therapy [HR 18.1 (95% CI 2.6–122.9); p =0.003]; TNFα > 80 ng/ml [HR 5.85 (95% CI 1.1–31.42); p =0.039]; and TIMP-2 > 289 ng/ml [HR 0.52 (95% CI 0.22–0.95); p =0.045]. Conclusion Chronic inflammation and ECM remodeling are involved in late mitral restenosis after PMC.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - metabolism</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiovascular</subject><subject>Chronic inflammation</subject><subject>Critical Care</subject><subject>Echocardiography</subject><subject>Extracellular Matrix - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix metalloproteinases</subject><subject>Middle Aged</subject><subject>Mitral restenosis</subject><subject>Mitral stenosis</subject><subject>Mitral Valve - surgery</subject><subject>Mitral Valve Stenosis - diagnosis</subject><subject>Mitral Valve Stenosis - metabolism</subject><subject>Mitral Valve Stenosis - surgery</subject><subject>Percutaneous mitral commissurotomy</subject><subject>Postoperative Complications</subject><subject>Prospective Studies</subject><subject>Pulmonary/Respiratory</subject><subject>Recurrence</subject><subject>Time Factors</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - metabolism</subject><subject>TNFα</subject><issn>0147-9563</issn><issn>1527-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsFu1DAQtRCIbgt_gJCPXBLGcWxnOSChCijSSiABZ8txJsVbJ15sZ9X9BP4aR1s4cMGXOfjNvHnvDSEvGNQMmHy9r3_E7OfbugGmauA1gHxENkw0quJN1z0mG2CtqrZC8gtymdIeyuNSPSUXTdcKYAI25NfOZKSTy9F4GjFlnENyiZoxY6QHjHbJZsawJGrDNLmUlhhymE5v6JeIg7PZHZEejV-QhpG6efRmmkx2YaZmHijel8kWvV-8ibR8RHdfeKYwoHfzLe1dmEy8w5iekSej8QmfP9Qr8v3D-2_XN9Xu88dP1-92lW2ZyhVXCoww_SjaVsm2G1sFPUDDVaFpOqVUz9hWyV4KLnroWzYMZgAYO8mEZJJfkVfnuYcYfi5FsS6q1g3PMjXrtlwIUJwVaHuG2hhSijjqQ3Rl3ZNmoNcQ9F6fQ9BrCBq4LiGUtpcPDEs_4fC36Y_rBfD2DMCi8-gw6mQdzrb4GdFmPQT3P4Z_B9jiprPG3-EJ0z4scS4eaqZTo0F_XQ9hvQOmeLkB1vHfzEGySQ</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Mechmeche, Rachid, MD</creator><creator>Zaroui, Amira, MD</creator><creator>Aloui, Sonia, MD</creator><creator>Boukhris, Marouane, MD</creator><creator>Allal-Elasmi, Monia, MD</creator><creator>Kaabachi, Naziha, MD</creator><creator>Zouari, Bechir, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers</title><author>Mechmeche, Rachid, MD ; Zaroui, Amira, MD ; Aloui, Sonia, MD ; Boukhris, Marouane, MD ; Allal-Elasmi, Monia, MD ; Kaabachi, Naziha, MD ; Zouari, Bechir, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3770a5abf5447648f470b00237ace28777b11976b6535b0b41ddad00f86156163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - metabolism</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiovascular</topic><topic>Chronic inflammation</topic><topic>Critical Care</topic><topic>Echocardiography</topic><topic>Extracellular Matrix - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix metalloproteinases</topic><topic>Middle Aged</topic><topic>Mitral restenosis</topic><topic>Mitral stenosis</topic><topic>Mitral Valve - surgery</topic><topic>Mitral Valve Stenosis - diagnosis</topic><topic>Mitral Valve Stenosis - metabolism</topic><topic>Mitral Valve Stenosis - surgery</topic><topic>Percutaneous mitral commissurotomy</topic><topic>Postoperative Complications</topic><topic>Prospective Studies</topic><topic>Pulmonary/Respiratory</topic><topic>Recurrence</topic><topic>Time Factors</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - metabolism</topic><topic>TNFα</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mechmeche, Rachid, MD</creatorcontrib><creatorcontrib>Zaroui, Amira, MD</creatorcontrib><creatorcontrib>Aloui, Sonia, MD</creatorcontrib><creatorcontrib>Boukhris, Marouane, MD</creatorcontrib><creatorcontrib>Allal-Elasmi, Monia, MD</creatorcontrib><creatorcontrib>Kaabachi, Naziha, MD</creatorcontrib><creatorcontrib>Zouari, Bechir, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart & lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mechmeche, Rachid, MD</au><au>Zaroui, Amira, MD</au><au>Aloui, Sonia, MD</au><au>Boukhris, Marouane, MD</au><au>Allal-Elasmi, Monia, MD</au><au>Kaabachi, Naziha, MD</au><au>Zouari, Bechir, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers</atitle><jtitle>Heart & lung</jtitle><addtitle>Heart Lung</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>46</volume><issue>4</issue><spage>258</spage><epage>264</epage><pages>258-264</pages><issn>0147-9563</issn><eissn>1527-3288</eissn><abstract>Abstract Background The role of chronic inflammation in mitral restenosis after percutaneous mitral commissurotomy (PMC) is still controversial. Aims We sought to assess the predictive value of inflammation and extracellular matrix (ECM) remodeling biomarkers in late mitral restenosis after PMC. Methods We prospectively enrolled 155 patients (mean age 46.2±11 years) with at least 5 year follow up after primary PMC. Serum levels of high sensitive C-Reactive Protein (hs-CRP), matrix metalloproteinases MMPs, tissue-specific inhibitors of matrix metalloproteinases TIMPs, and tumor necrosis factor α (TNFα)] were measured. Results Late mitral restenosis occurred in 55 patients (35.5%). The independent predictors of late mitral stenosis were: age> 55 years [HR10.51 (95%CI 1.12–95.9); p =0.037]; no long acting penicillin therapy [HR 18.1 (95% CI 2.6–122.9); p =0.003]; TNFα > 80 ng/ml [HR 5.85 (95% CI 1.1–31.42); p =0.039]; and TIMP-2 > 289 ng/ml [HR 0.52 (95% CI 0.22–0.95); p =0.045]. Conclusion Chronic inflammation and ECM remodeling are involved in late mitral restenosis after PMC.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28450150</pmid><doi>10.1016/j.hrtlng.2017.03.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Biomarkers - metabolism C-Reactive Protein - metabolism Cardiac Surgical Procedures - adverse effects Cardiovascular Chronic inflammation Critical Care Echocardiography Extracellular Matrix - metabolism Female Follow-Up Studies Humans Male Matrix metalloproteinases Middle Aged Mitral restenosis Mitral stenosis Mitral Valve - surgery Mitral Valve Stenosis - diagnosis Mitral Valve Stenosis - metabolism Mitral Valve Stenosis - surgery Percutaneous mitral commissurotomy Postoperative Complications Prospective Studies Pulmonary/Respiratory Recurrence Time Factors Tissue Inhibitor of Metalloproteinase-2 - metabolism TNFα |
| title | Late mitral restenosis after percutaneous commissurotomy: Predictive value of inflammation and extracellular matrix remodeling biomarkers |
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