Skeletal energy homeostasis: a paradigm of endocrine discovery
Throughout the last decade, significant developments in cellular, molecular and mouse models have revealed major endocrine functions of the skeleton. More recent studies have evolved the interplay between bone-specific hormones, the skeleton, marrow adipose tissue, muscle and the brain. This review...
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| Veröffentlicht in: | Journal of endocrinology 2017-07, Vol.234 (1), p.R67-R79 |
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| container_end_page | R79 |
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| container_issue | 1 |
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| container_title | Journal of endocrinology |
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| creator | Suchacki, Karla J Roberts, Fiona Lovdel, Andrea Farquharson, Colin Morton, Nik M MacRae, Vicky E Cawthorn, William P |
| description | Throughout the last decade, significant developments in cellular, molecular and mouse models have revealed major endocrine functions of the skeleton. More recent studies have evolved the interplay between bone-specific hormones, the skeleton, marrow adipose tissue, muscle and the brain. This review focuses on literature from the last decade, addressing the endocrine regulation of global energy metabolism via the skeleton. In addition, we will highlight several recent studies that further our knowledge of new endocrine functions of some organs; explore remaining unanswered questions; and, finally, we will discuss future directions for this more complex era of bone biology research. |
| doi_str_mv | 10.1530/JOE-17-0147 |
| format | Article |
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| ispartof | Journal of endocrinology, 2017-07, Vol.234 (1), p.R67-R79 |
| issn | 0022-0795 1479-6805 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose tissue Adipose Tissue - physiology Animal models Animals Anorexia Bone and Bones - metabolism Bone Diseases Bone Marrow Diabetes Mellitus Endocrine System - physiology Energy balance Energy metabolism Energy Metabolism - physiology Female Homeostasis Homeostasis - physiology Humans Liver Diseases Male Mice Molecular modelling Multiple Myeloma Obesity Osteocalcin Pancreatic Diseases PPAR gamma Review Rodents Skeleton |
| title | Skeletal energy homeostasis: a paradigm of endocrine discovery |
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