Layer-by-Layer polyelectrolyte assemblies for encapsulation and release of active compounds

Soft assemblies obtained following the Layer-by-Layer (LbL) approach are accounted among the most interesting systems for designing biomaterials and drug delivery platforms. This is due to the extraordinary versatility and flexibility offered by the LbL method, allowing for the fabrication of supram...

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Veröffentlicht in:Advances in colloid and interface science 2017-11, Vol.249, p.290-307
Hauptverfasser: Guzmán, Eduardo, Mateos-Maroto, Ana, Ruano, Marta, Ortega, Francisco, Rubio, Ramón G.
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container_end_page 307
container_issue
container_start_page 290
container_title Advances in colloid and interface science
container_volume 249
creator Guzmán, Eduardo
Mateos-Maroto, Ana
Ruano, Marta
Ortega, Francisco
Rubio, Ramón G.
description Soft assemblies obtained following the Layer-by-Layer (LbL) approach are accounted among the most interesting systems for designing biomaterials and drug delivery platforms. This is due to the extraordinary versatility and flexibility offered by the LbL method, allowing for the fabrication of supramolecular multifunctional materials using a wide range of building blocks through different types of interactions (electrostatic, hydrogen bonds, acid-base or coordination interactions, or even covalent bonds). This provides the bases for the building of materials with different sizes, shapes, compositions and morphologies, gathering important possibilities for tuning and controlling the physico-chemical properties of the assembled materials with precision in the nanometer scale, and consequently creating important perspective for the application of these multifunctional materials as cargo systems in many areas of technological interest. This review studies different physico – chemical aspects associated with the assembly of supramolecular materials by the LbL method, paying special attention to the description of these aspects playing a central role in the application of these materials as cargo platforms for encapsulation and release of active compounds. [Display omitted] •Layer-by-Layer (LbL) films present many potential applications for encapsulating active ingredients.•The versatility of the LbL methods allows tuning the properties of the encapsulation platforms.•Real applications of LbL materials are in the initial steps.•Many questions are open about LbL materials yet.
doi_str_mv 10.1016/j.cis.2017.04.009
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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Acrylic Resins - chemistry
Active compounds
Cargo systems
Drug Compounding - methods
Drug delivery
Drug Delivery Systems
Drug Liberation
Fluorescent Dyes - chemistry
Hydrogen Bonding
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Kinetics
Layer-by-Layer
Multilayers
Osmolar Concentration
Polyelectrolytes
Polyelectrolytes - chemistry
Polyethylenes - chemistry
Polyvinyls - chemistry
Quaternary Ammonium Compounds - chemistry
Self-assembly
Static Electricity
Surface Properties
Temperature
title Layer-by-Layer polyelectrolyte assemblies for encapsulation and release of active compounds
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