Frozen–thawed blastocyst transfer in natural cycle: feasibility in everyday clinical practice
Purpose Transfer of frozen–thawed embryos in natural cycle is gaining consensus but evidence on this approach is scanty. The aim of this study is reporting on the feasibility of this type of policy in everyday clinical practice. Methods We retrospectively selected all women undergoing the procedure...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2017-06, Vol.295 (6), p.1509-1514 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Cardellicchio, Lucia Reschini, Marco Paffoni, Alessio Guarneri, Cristina Restelli, Liliana Somigliana, Edgardo Vegetti, Walter |
| description | Purpose
Transfer of frozen–thawed embryos in natural cycle is gaining consensus but evidence on this approach is scanty. The aim of this study is reporting on the feasibility of this type of policy in everyday clinical practice.
Methods
We retrospectively selected all women undergoing the procedure between July 2013 and December 2014. During the study period, women were systematically scheduled for natural cycle if they referred regular menstrual cycles. Hormone replacement therapy (HRT) was conversely prescribed if the woman had irregular menstrual cycles or if the monitoring of the natural cycle failed. The analysis exclusively focussed on the first cycle per woman.
Results
Overall, 251 women were selected. HRT was initially chosen in 52 women, leaving 199 women suitable for the natural cycle. This procedure could be performed in 194 of these women (97%, 95% CI 95–99%). Two additional women initially allocated to HRT ultimately performed the blastocyst transfer with natural cycle. Overall, 196 were thus treated with natural cycle (78%, 95% CI 73–83%). The basal characteristics of the women who did and did not undergo natural cycles were similar with the exceptions of serum FSH (
p
|
| doi_str_mv | 10.1007/s00404-017-4383-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1893549317</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1893549317</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-ded367ecab7a10e0682357f8090c040c2be818f5803de91aa5c84a6cfb28dbc53</originalsourceid><addsrcrecordid>eNp1kMFO3DAQhq2qVVmgD9BLFamXXgJjO44dbtWKBSQkLuVsOc6k9SqbLLYDyp54B96wT4KjpSBV4jQjzTf_2B8hXymcUAB5GgAKKHKgMi-44vnuA1nQgrMcJKUfyQKquYdSHpDDENYAlClVfiYHTBVCCEUXRK_8sMP-7-NT_GMesMnqzoQ42CnELHrThxZ95vqsN3H0psvsZDs8y1o0wdWuc3Gap3iPfmrMlNnO9c4mbuuNjc7iMfnUmi7gl5d6RG5X57-Wl_n1zcXV8ud1brlkMW-w4aVEa2ppKCCUinEhWwUV2PRHy2pUVLVCAW-wosYIqwpT2rZmqqmt4Efkxz5364e7EUPUGxcsdp3pcRiDpqrioqg4lQn9_h-6Hkbfp9dpxkoqeLo-B9I9Zf0QgsdWb73bGD9pCnq2r_f2dbKvZ_t6l3a-vSSP9Qab141_uhPA9kBIo_43-rfT76c-AyMQkjc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261530685</pqid></control><display><type>article</type><title>Frozen–thawed blastocyst transfer in natural cycle: feasibility in everyday clinical practice</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Cardellicchio, Lucia ; Reschini, Marco ; Paffoni, Alessio ; Guarneri, Cristina ; Restelli, Liliana ; Somigliana, Edgardo ; Vegetti, Walter</creator><creatorcontrib>Cardellicchio, Lucia ; Reschini, Marco ; Paffoni, Alessio ; Guarneri, Cristina ; Restelli, Liliana ; Somigliana, Edgardo ; Vegetti, Walter</creatorcontrib><description>Purpose
Transfer of frozen–thawed embryos in natural cycle is gaining consensus but evidence on this approach is scanty. The aim of this study is reporting on the feasibility of this type of policy in everyday clinical practice.
Methods
We retrospectively selected all women undergoing the procedure between July 2013 and December 2014. During the study period, women were systematically scheduled for natural cycle if they referred regular menstrual cycles. Hormone replacement therapy (HRT) was conversely prescribed if the woman had irregular menstrual cycles or if the monitoring of the natural cycle failed. The analysis exclusively focussed on the first cycle per woman.
Results
Overall, 251 women were selected. HRT was initially chosen in 52 women, leaving 199 women suitable for the natural cycle. This procedure could be performed in 194 of these women (97%, 95% CI 95–99%). Two additional women initially allocated to HRT ultimately performed the blastocyst transfer with natural cycle. Overall, 196 were thus treated with natural cycle (78%, 95% CI 73–83%). The basal characteristics of the women who did and did not undergo natural cycles were similar with the exceptions of serum FSH (
p
< 0.001) and AMH (
p
= 0.03). The live birth rate did not also differ (34% versus 31%,
p
= 0.63). Characteristics of women treated with the natural cycle who did (
n
= 67) and did not (
n
= 129) achieve a live birth did not differ.
Conclusion
Frozen–thawed blastocyst transfer in natural cycle can be successfully performed in the vast majority of women.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-017-4383-z</identifier><identifier>PMID: 28455581</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Birth Rate ; Clinical medicine ; Cryopreservation - methods ; Embryo Transfer - methods ; Endocrinology ; Female ; Fertilization in Vitro ; Gynecologic Endocrinology and Reproductive Medicine ; Gynecology ; Human Genetics ; Humans ; Live Birth ; Medicine ; Medicine & Public Health ; Menstrual Cycle ; Menstruation ; Obstetrics/Perinatology/Midwifery ; Pregnancy ; Retrospective Studies ; Women</subject><ispartof>Archives of gynecology and obstetrics, 2017-06, Vol.295 (6), p.1509-1514</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ded367ecab7a10e0682357f8090c040c2be818f5803de91aa5c84a6cfb28dbc53</citedby><cites>FETCH-LOGICAL-c372t-ded367ecab7a10e0682357f8090c040c2be818f5803de91aa5c84a6cfb28dbc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-017-4383-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-017-4383-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28455581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cardellicchio, Lucia</creatorcontrib><creatorcontrib>Reschini, Marco</creatorcontrib><creatorcontrib>Paffoni, Alessio</creatorcontrib><creatorcontrib>Guarneri, Cristina</creatorcontrib><creatorcontrib>Restelli, Liliana</creatorcontrib><creatorcontrib>Somigliana, Edgardo</creatorcontrib><creatorcontrib>Vegetti, Walter</creatorcontrib><title>Frozen–thawed blastocyst transfer in natural cycle: feasibility in everyday clinical practice</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
Transfer of frozen–thawed embryos in natural cycle is gaining consensus but evidence on this approach is scanty. The aim of this study is reporting on the feasibility of this type of policy in everyday clinical practice.
Methods
We retrospectively selected all women undergoing the procedure between July 2013 and December 2014. During the study period, women were systematically scheduled for natural cycle if they referred regular menstrual cycles. Hormone replacement therapy (HRT) was conversely prescribed if the woman had irregular menstrual cycles or if the monitoring of the natural cycle failed. The analysis exclusively focussed on the first cycle per woman.
Results
Overall, 251 women were selected. HRT was initially chosen in 52 women, leaving 199 women suitable for the natural cycle. This procedure could be performed in 194 of these women (97%, 95% CI 95–99%). Two additional women initially allocated to HRT ultimately performed the blastocyst transfer with natural cycle. Overall, 196 were thus treated with natural cycle (78%, 95% CI 73–83%). The basal characteristics of the women who did and did not undergo natural cycles were similar with the exceptions of serum FSH (
p
< 0.001) and AMH (
p
= 0.03). The live birth rate did not also differ (34% versus 31%,
p
= 0.63). Characteristics of women treated with the natural cycle who did (
n
= 67) and did not (
n
= 129) achieve a live birth did not differ.
Conclusion
Frozen–thawed blastocyst transfer in natural cycle can be successfully performed in the vast majority of women.</description><subject>Adult</subject><subject>Birth Rate</subject><subject>Clinical medicine</subject><subject>Cryopreservation - methods</subject><subject>Embryo Transfer - methods</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gynecologic Endocrinology and Reproductive Medicine</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Live Birth</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menstrual Cycle</subject><subject>Menstruation</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>Women</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMFO3DAQhq2qVVmgD9BLFamXXgJjO44dbtWKBSQkLuVsOc6k9SqbLLYDyp54B96wT4KjpSBV4jQjzTf_2B8hXymcUAB5GgAKKHKgMi-44vnuA1nQgrMcJKUfyQKquYdSHpDDENYAlClVfiYHTBVCCEUXRK_8sMP-7-NT_GMesMnqzoQ42CnELHrThxZ95vqsN3H0psvsZDs8y1o0wdWuc3Gap3iPfmrMlNnO9c4mbuuNjc7iMfnUmi7gl5d6RG5X57-Wl_n1zcXV8ud1brlkMW-w4aVEa2ppKCCUinEhWwUV2PRHy2pUVLVCAW-wosYIqwpT2rZmqqmt4Efkxz5364e7EUPUGxcsdp3pcRiDpqrioqg4lQn9_h-6Hkbfp9dpxkoqeLo-B9I9Zf0QgsdWb73bGD9pCnq2r_f2dbKvZ_t6l3a-vSSP9Qab141_uhPA9kBIo_43-rfT76c-AyMQkjc</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Cardellicchio, Lucia</creator><creator>Reschini, Marco</creator><creator>Paffoni, Alessio</creator><creator>Guarneri, Cristina</creator><creator>Restelli, Liliana</creator><creator>Somigliana, Edgardo</creator><creator>Vegetti, Walter</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Frozen–thawed blastocyst transfer in natural cycle: feasibility in everyday clinical practice</title><author>Cardellicchio, Lucia ; Reschini, Marco ; Paffoni, Alessio ; Guarneri, Cristina ; Restelli, Liliana ; Somigliana, Edgardo ; Vegetti, Walter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ded367ecab7a10e0682357f8090c040c2be818f5803de91aa5c84a6cfb28dbc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Birth Rate</topic><topic>Clinical medicine</topic><topic>Cryopreservation - methods</topic><topic>Embryo Transfer - methods</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gynecologic Endocrinology and Reproductive Medicine</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Live Birth</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menstrual Cycle</topic><topic>Menstruation</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardellicchio, Lucia</creatorcontrib><creatorcontrib>Reschini, Marco</creatorcontrib><creatorcontrib>Paffoni, Alessio</creatorcontrib><creatorcontrib>Guarneri, Cristina</creatorcontrib><creatorcontrib>Restelli, Liliana</creatorcontrib><creatorcontrib>Somigliana, Edgardo</creatorcontrib><creatorcontrib>Vegetti, Walter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardellicchio, Lucia</au><au>Reschini, Marco</au><au>Paffoni, Alessio</au><au>Guarneri, Cristina</au><au>Restelli, Liliana</au><au>Somigliana, Edgardo</au><au>Vegetti, Walter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frozen–thawed blastocyst transfer in natural cycle: feasibility in everyday clinical practice</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>295</volume><issue>6</issue><spage>1509</spage><epage>1514</epage><pages>1509-1514</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
Transfer of frozen–thawed embryos in natural cycle is gaining consensus but evidence on this approach is scanty. The aim of this study is reporting on the feasibility of this type of policy in everyday clinical practice.
Methods
We retrospectively selected all women undergoing the procedure between July 2013 and December 2014. During the study period, women were systematically scheduled for natural cycle if they referred regular menstrual cycles. Hormone replacement therapy (HRT) was conversely prescribed if the woman had irregular menstrual cycles or if the monitoring of the natural cycle failed. The analysis exclusively focussed on the first cycle per woman.
Results
Overall, 251 women were selected. HRT was initially chosen in 52 women, leaving 199 women suitable for the natural cycle. This procedure could be performed in 194 of these women (97%, 95% CI 95–99%). Two additional women initially allocated to HRT ultimately performed the blastocyst transfer with natural cycle. Overall, 196 were thus treated with natural cycle (78%, 95% CI 73–83%). The basal characteristics of the women who did and did not undergo natural cycles were similar with the exceptions of serum FSH (
p
< 0.001) and AMH (
p
= 0.03). The live birth rate did not also differ (34% versus 31%,
p
= 0.63). Characteristics of women treated with the natural cycle who did (
n
= 67) and did not (
n
= 129) achieve a live birth did not differ.
Conclusion
Frozen–thawed blastocyst transfer in natural cycle can be successfully performed in the vast majority of women.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28455581</pmid><doi>10.1007/s00404-017-4383-z</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2017-06, Vol.295 (6), p.1509-1514 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1893549317 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Birth Rate Clinical medicine Cryopreservation - methods Embryo Transfer - methods Endocrinology Female Fertilization in Vitro Gynecologic Endocrinology and Reproductive Medicine Gynecology Human Genetics Humans Live Birth Medicine Medicine & Public Health Menstrual Cycle Menstruation Obstetrics/Perinatology/Midwifery Pregnancy Retrospective Studies Women |
| title | Frozen–thawed blastocyst transfer in natural cycle: feasibility in everyday clinical practice |
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