GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma
In the current study, we aimed to compare the prevalence of adverse lifetime events in treatment resistant and non-treatment resistant schizophrenia in a genome-wide association study. Our sample consisted of 84 Caucasian participants with schizophrenia spectrum disorders, assessed cross-sectionally...
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| Veröffentlicht in: | Pharmacogenomics 2017-05, Vol.18 (7), p.663-671 |
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| container_title | Pharmacogenomics |
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| creator | Koga, Arthur Bani-Fatemi, Ali Hettige, Nuwan Borlido, Carol Zai, Clement Strauss, John Gerretsen, Philip Graff, Ariel Remington, Gary De Luca, Vincenzo |
| description | In the current study, we aimed to compare the prevalence of adverse lifetime events in treatment resistant and non-treatment resistant schizophrenia in a genome-wide association study.
Our sample consisted of 84 Caucasian participants with schizophrenia spectrum disorders, assessed cross-sectionally to collect information regarding drug effectiveness and childhood trauma. Using a genome-wide association analysis, we tested single-nucleotide polymorphisms for their association with resistance to antipsychotics defined according to American Psychiatric Association criteria. Two models were tested: a main model and an interaction model with the childhood trauma.
Our analysis failed to demonstrate a significant relationship among 1,178,234 single-nucleotide polymorphisms and treatment-resistance in both the main model and in the childhood trauma interaction model.
Even though we could not find any significant association, treatment resistance has clinical relevance and it may be determined by the interaction between biological and non biological factors. |
| doi_str_mv | 10.2217/pgs-2016-0137 |
| format | Article |
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Our sample consisted of 84 Caucasian participants with schizophrenia spectrum disorders, assessed cross-sectionally to collect information regarding drug effectiveness and childhood trauma. Using a genome-wide association analysis, we tested single-nucleotide polymorphisms for their association with resistance to antipsychotics defined according to American Psychiatric Association criteria. Two models were tested: a main model and an interaction model with the childhood trauma.
Our analysis failed to demonstrate a significant relationship among 1,178,234 single-nucleotide polymorphisms and treatment-resistance in both the main model and in the childhood trauma interaction model.
Even though we could not find any significant association, treatment resistance has clinical relevance and it may be determined by the interaction between biological and non biological factors.</description><identifier>ISSN: 1462-2416</identifier><identifier>EISSN: 1744-8042</identifier><identifier>DOI: 10.2217/pgs-2016-0137</identifier><identifier>PMID: 28453389</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Antipsychotic Agents - therapeutic use ; Antipsychotics ; Association analysis ; Child abuse & neglect ; Child Abuse - psychology ; Childhood ; Children ; Cohort Studies ; Cross-Sectional Studies ; Drug abuse ; Female ; Genome-wide association studies ; genome-wide association study ; Genome-Wide Association Study - methods ; Genomes ; Humans ; Male ; Mental disorders ; Mental health ; Middle Aged ; Patients ; Polymorphism, Single Nucleotide - genetics ; Psychiatry ; Psychosis ; Psychotropic drugs ; Quality control ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - drug therapy ; Schizophrenia - genetics ; Schizophrenic Psychology ; Self Report ; Single-nucleotide polymorphism ; Studies ; Suicides & suicide attempts ; Trauma ; Treatment Outcome ; Treatment resistance ; Young Adult</subject><ispartof>Pharmacogenomics, 2017-05, Vol.18 (7), p.663-671</ispartof><rights>Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd May 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-8e2cf08b692a8cefb0f9eddff40eb76bfb1145b538fae3185982a0c23571d9be3</citedby><cites>FETCH-LOGICAL-c371t-8e2cf08b692a8cefb0f9eddff40eb76bfb1145b538fae3185982a0c23571d9be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28453389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koga, Arthur</creatorcontrib><creatorcontrib>Bani-Fatemi, Ali</creatorcontrib><creatorcontrib>Hettige, Nuwan</creatorcontrib><creatorcontrib>Borlido, Carol</creatorcontrib><creatorcontrib>Zai, Clement</creatorcontrib><creatorcontrib>Strauss, John</creatorcontrib><creatorcontrib>Gerretsen, Philip</creatorcontrib><creatorcontrib>Graff, Ariel</creatorcontrib><creatorcontrib>Remington, Gary</creatorcontrib><creatorcontrib>De Luca, Vincenzo</creatorcontrib><title>GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma</title><title>Pharmacogenomics</title><addtitle>Pharmacogenomics</addtitle><description>In the current study, we aimed to compare the prevalence of adverse lifetime events in treatment resistant and non-treatment resistant schizophrenia in a genome-wide association study.
Our sample consisted of 84 Caucasian participants with schizophrenia spectrum disorders, assessed cross-sectionally to collect information regarding drug effectiveness and childhood trauma. Using a genome-wide association analysis, we tested single-nucleotide polymorphisms for their association with resistance to antipsychotics defined according to American Psychiatric Association criteria. Two models were tested: a main model and an interaction model with the childhood trauma.
Our analysis failed to demonstrate a significant relationship among 1,178,234 single-nucleotide polymorphisms and treatment-resistance in both the main model and in the childhood trauma interaction model.
Even though we could not find any significant association, treatment resistance has clinical relevance and it may be determined by the interaction between biological and non biological factors.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Antipsychotics</subject><subject>Association analysis</subject><subject>Child abuse & neglect</subject><subject>Child Abuse - psychology</subject><subject>Childhood</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Drug abuse</subject><subject>Female</subject><subject>Genome-wide association studies</subject><subject>genome-wide association study</subject><subject>Genome-Wide Association Study - methods</subject><subject>Genomes</subject><subject>Humans</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatry</subject><subject>Psychosis</subject><subject>Psychotropic drugs</subject><subject>Quality control</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenic Psychology</subject><subject>Self Report</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Suicides & suicide attempts</subject><subject>Trauma</subject><subject>Treatment Outcome</subject><subject>Treatment resistance</subject><subject>Young Adult</subject><issn>1462-2416</issn><issn>1744-8042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAQhoMo7rp69CoFL16q-WqbelvELxA8qAheQppO3CxtsybpYf31Zln1IHjKZHjmZeZB6Jjgc0pJdbF6DznFpMwxYdUOmpKK81xgTndTzUuaU07KCToIYYkxJSXH-2hCBS8YE_UUvd2-zp8yNahuHWzInMmiBxV7GGLmIbWiSlXQC_vpVgsPg1WXmR0ieKWjdUMGxoCOm8HEdO3CuTZFqLFXh2jPqC7A0fc7Qy83189Xd_nD4-391fwh16wiMRdAtcGiKWuqhAbTYFND2xrDMTRV2ZiGEF40BRNGASOiqAVVWFNWVKStG2AzdLbNXXn3MUKIsrdBQ9epAdwYJBE1K3jFRZXQ0z_o0o0-HR8kZTRtILAgicq3lPYuBA9GrrztlV9LguVGukzS5Ua63EhP_Ml36tj00P7SP5YTUG8BM8YxWdUWBg1y-0sTVtsB_gn_Ai84kdQ</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Koga, Arthur</creator><creator>Bani-Fatemi, Ali</creator><creator>Hettige, Nuwan</creator><creator>Borlido, Carol</creator><creator>Zai, Clement</creator><creator>Strauss, John</creator><creator>Gerretsen, Philip</creator><creator>Graff, Ariel</creator><creator>Remington, Gary</creator><creator>De Luca, Vincenzo</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma</title><author>Koga, Arthur ; Bani-Fatemi, Ali ; Hettige, Nuwan ; Borlido, Carol ; Zai, Clement ; Strauss, John ; Gerretsen, Philip ; Graff, Ariel ; Remington, Gary ; De Luca, Vincenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-8e2cf08b692a8cefb0f9eddff40eb76bfb1145b538fae3185982a0c23571d9be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Antipsychotics</topic><topic>Association analysis</topic><topic>Child abuse & neglect</topic><topic>Child Abuse - psychology</topic><topic>Childhood</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Drug abuse</topic><topic>Female</topic><topic>Genome-wide association studies</topic><topic>genome-wide association study</topic><topic>Genome-Wide Association Study - methods</topic><topic>Genomes</topic><topic>Humans</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatry</topic><topic>Psychosis</topic><topic>Psychotropic drugs</topic><topic>Quality control</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenic Psychology</topic><topic>Self Report</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>Suicides & suicide attempts</topic><topic>Trauma</topic><topic>Treatment Outcome</topic><topic>Treatment resistance</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koga, Arthur</creatorcontrib><creatorcontrib>Bani-Fatemi, Ali</creatorcontrib><creatorcontrib>Hettige, Nuwan</creatorcontrib><creatorcontrib>Borlido, Carol</creatorcontrib><creatorcontrib>Zai, Clement</creatorcontrib><creatorcontrib>Strauss, John</creatorcontrib><creatorcontrib>Gerretsen, Philip</creatorcontrib><creatorcontrib>Graff, Ariel</creatorcontrib><creatorcontrib>Remington, Gary</creatorcontrib><creatorcontrib>De Luca, Vincenzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacogenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koga, Arthur</au><au>Bani-Fatemi, Ali</au><au>Hettige, Nuwan</au><au>Borlido, Carol</au><au>Zai, Clement</au><au>Strauss, John</au><au>Gerretsen, Philip</au><au>Graff, Ariel</au><au>Remington, Gary</au><au>De Luca, Vincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma</atitle><jtitle>Pharmacogenomics</jtitle><addtitle>Pharmacogenomics</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>18</volume><issue>7</issue><spage>663</spage><epage>671</epage><pages>663-671</pages><issn>1462-2416</issn><eissn>1744-8042</eissn><abstract>In the current study, we aimed to compare the prevalence of adverse lifetime events in treatment resistant and non-treatment resistant schizophrenia in a genome-wide association study.
Our sample consisted of 84 Caucasian participants with schizophrenia spectrum disorders, assessed cross-sectionally to collect information regarding drug effectiveness and childhood trauma. Using a genome-wide association analysis, we tested single-nucleotide polymorphisms for their association with resistance to antipsychotics defined according to American Psychiatric Association criteria. Two models were tested: a main model and an interaction model with the childhood trauma.
Our analysis failed to demonstrate a significant relationship among 1,178,234 single-nucleotide polymorphisms and treatment-resistance in both the main model and in the childhood trauma interaction model.
Even though we could not find any significant association, treatment resistance has clinical relevance and it may be determined by the interaction between biological and non biological factors.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>28453389</pmid><doi>10.2217/pgs-2016-0137</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pharmacogenomics, 2017-05, Vol.18 (7), p.663-671 |
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| subjects | Adolescent Adult Aged Antipsychotic Agents - therapeutic use Antipsychotics Association analysis Child abuse & neglect Child Abuse - psychology Childhood Children Cohort Studies Cross-Sectional Studies Drug abuse Female Genome-wide association studies genome-wide association study Genome-Wide Association Study - methods Genomes Humans Male Mental disorders Mental health Middle Aged Patients Polymorphism, Single Nucleotide - genetics Psychiatry Psychosis Psychotropic drugs Quality control Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenic Psychology Self Report Single-nucleotide polymorphism Studies Suicides & suicide attempts Trauma Treatment Outcome Treatment resistance Young Adult |
| title | GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma |
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