Radiation synthesis and drug delivery properties of interpenetrating networks (IPNs) based on poly(vinyl alcohol)/ methylcellulose blend hydrogels

•Blend hydrogels of PVA/MC were synthesized by gamma irradiation in aqueous solutions.•The PVA/MC hydrogels showed swelling pH-sensitivity.•The PVA/MC hydrogels were used as a carrier for doxycycline hyclate (DOX-h) drug.•The hydrogels displayed controlled release depending on composition and pH val...

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Veröffentlicht in:	International journal of biological macromolecules 2017-09, Vol.102, p.1045-1051
Hauptverfasser:	El-Naggar, Abdel Wahab M., Senna, Magdy M., Mostafa, Tahia A., Helal, Reham H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Techniques, Synthetic Doxycycline - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Liberation Drug release DSC Gamma radiation Gamma Rays Hydrogels Hydrogels - chemical synthesis Hydrogels - chemistry Hydrogen-Ion Concentration Methylcellulose Methylcellulose - chemistry Poly(vinyl alcohol) Polyvinyl Alcohol - chemistry Radiochemistry
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