Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus

Imidazoline drugs exert neuroprotective effects in cerebral ischaemia models. They also have effects against mouse cerebellar and striatal neuronal death induced by N-methyl- d-aspartate (NMDA) through the blockade of NMDA currents. Here, we investigated the effects of antazoline on NMDA toxicity an...

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Veröffentlicht in:	Neuroscience 2003-01, Vol.120 (2), p.475-484
Hauptverfasser:	Milhaud, D, Rondouin, G, Lerner-natoli, M, Bockaert, J, Lafon-Cazal, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn antazoline Antazoline - therapeutic use Biological and medical sciences Cell Count Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - injuries Cerebral Cortex - physiopathology cortex Disease Models, Animal Dose-Response Relationship, Drug Drug Interactions Electric Conductivity Electroencephalography - instrumentation Electroencephalography - methods Excitatory Amino Acid Agonists Female hippocampus Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology Histamine H1 Antagonists - therapeutic use imidazoline In Vitro Techniques Male Medical sciences Muscarinic Agonists - administration & dosage N-Methylaspartate Neurons - drug effects Neurons - physiology Neuropharmacology Neuroprotective agent NMDA neurotoxicity Patch-Clamp Techniques Pharmacology. Drug treatments pilocarpine Pilocarpine - administration & dosage Pregnancy Rats Rats, Sprague-Dawley Status Epilepticus - chemically induced Status Epilepticus - complications Time Factors Trauma, Nervous System - etiology Trauma, Nervous System - prevention & control
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