Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene

Defects in energy metabolism and oxidative stress play an important role in the pathogenesis of Alzheimer's Disease (AD). In sporadic AD cases, presenilin 2 (PS2) mRNA levels are decreased in brain areas affected by the disease. The aim of the present study was to investigate whether mitochondr...

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Veröffentlicht in:	Journal of Neural Transmission 2003-09, Vol.110 (9), p.1029-1039
Hauptverfasser:	GHIDONI, R, GASPARINI, L, ZANETTI, O, BINETTI, G, ALBERICI, A, BENUSSI, L, BARBIERO, L, MAZZOLI, F, NICOSIA, F, FINAZZI, D, BENERINI GATTA, L, ALBERTINI, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Antioxidants - pharmacology Biological and medical sciences Brain - metabolism Brain - physiopathology Cell Line, Tumor Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Down-Regulation - drug effects Down-Regulation - genetics Energy Metabolism - drug effects Energy Metabolism - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Humans Medical sciences Membrane Proteins - genetics Mitochondria - metabolism Neurology Oxidation-Reduction - drug effects Oxidative Stress - drug effects Oxidative Stress - genetics Presenilin-2 Promoter Regions, Genetic - genetics RNA, Messenger - metabolism Sodium Azide - pharmacology Transcription Factors - drug effects Transcription Factors - physiology Vertebrates: nervous system and sense organs
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