Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder
In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2017-07, Vol.77, p.222-227 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Kang, Seung-Gul Na, Kyoung-Sae Choi, Jae-Won Kim, Jeong-Hee Son, Young-Don Lee, Yu Jin |
| description | In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with MDD and 19 non-suicide attempters with MDD. RSFC was compared between the two groups and the regression analyses were conducted to identify the correlation between RSFC and Scale for Suicide Ideation (SSI) scores in the suicide attempt group. Statistical significance was set at p-value (uncorrected) |
| doi_str_mv | 10.1016/j.pnpbp.2017.04.029 |
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•We investigated the relationship between RSFC of the amygdala and suicide in MDD.•Suicide attempters had increased RSFC of the amygdala with several brain regions.•Significant correlation between RSFC of the amygdala and SSI was observed.•The results suggest a functional neural basis for suicidality in MDD.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2017.04.029</identifier><identifier>PMID: 28445688</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Amygdala ; Amygdala - pathology ; Amygdala - physiopathology ; Brain - pathology ; Brain - physiopathology ; Case-Control Studies ; Depressive Disorder, Major - pathology ; Depressive Disorder, Major - physiopathology ; fMRI ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging ; Major depressive disorder ; Neural Pathways - pathology ; Neural Pathways - physiopathology ; Rest ; Resting state functional connectivity ; Suicide attempt ; Suicide, Attempted</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2017-07, Vol.77, p.222-227</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-d99a328f9a7c25a91284aaeca83928cbf101ea3305b5efa534364007e3fceaf43</citedby><cites>FETCH-LOGICAL-c359t-d99a328f9a7c25a91284aaeca83928cbf101ea3305b5efa534364007e3fceaf43</cites><orcidid>0000-0001-6294-7046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2017.04.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28445688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Seung-Gul</creatorcontrib><creatorcontrib>Na, Kyoung-Sae</creatorcontrib><creatorcontrib>Choi, Jae-Won</creatorcontrib><creatorcontrib>Kim, Jeong-Hee</creatorcontrib><creatorcontrib>Son, Young-Don</creatorcontrib><creatorcontrib>Lee, Yu Jin</creatorcontrib><title>Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with MDD and 19 non-suicide attempters with MDD. RSFC was compared between the two groups and the regression analyses were conducted to identify the correlation between RSFC and Scale for Suicide Ideation (SSI) scores in the suicide attempt group. Statistical significance was set at p-value (uncorrected) <0.005 with k≥28 voxels. Compared with non-suicide attempters, suicide attempters showed significantly increased RSFC of the left amygdala with the right insula and left superior orbitofrontal area, and increased RSFC of the right amygdala with the left middle temporal area. The regression analysis showed a significant correlation between the SSI total score and RSFC of the right amygdala with the right parahippocampal area in the suicide attempt group. The present RSFC findings provide evidence of a functional neural basis and will help reveal the pathophysiology underlying suicidality in subjects with MDD.
•We investigated the relationship between RSFC of the amygdala and suicide in MDD.•Suicide attempters had increased RSFC of the amygdala with several brain regions.•Significant correlation between RSFC of the amygdala and SSI was observed.•The results suggest a functional neural basis for suicidality in MDD.</description><subject>Amygdala</subject><subject>Amygdala - pathology</subject><subject>Amygdala - physiopathology</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Case-Control Studies</subject><subject>Depressive Disorder, Major - pathology</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>fMRI</subject><subject>Functional Neuroimaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Major depressive disorder</subject><subject>Neural Pathways - pathology</subject><subject>Neural Pathways - physiopathology</subject><subject>Rest</subject><subject>Resting state functional connectivity</subject><subject>Suicide attempt</subject><subject>Suicide, Attempted</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtu1DAUhq2Kik4LT1AJeckmwbckzoIFqgpUqoRUwdry2Meto8QOtjNo3h6XKSxZnYv-c_k_hK4paSmh_YepXcO6X1tG6NAS0RI2nqEdlYNsBKP9K7QjrOadFP0Fusx5IoRQTvhrdMGkEF0v5Q5ND5CLD49NLroAdlswxcegZ2xiCFCLgy9HHB0uT4D1cny0etbYB5w3b7ytvVJgWQukjH_58oQXPcWELawJcvYHwNbnmCykN-jc6TnD25d4hX58vv1-87W5__bl7ubTfWN4N5bGjqPmTLpRD4Z1eqT1Wa3BaMlHJs3eVfOgOSfdvgOnOy54LwgZgDsD2gl-hd6f9q4p_tyqPbX4bGCedYC4ZUXlyAbW9ZRUKT9JTYo5J3BqTX7R6agoUc-Q1aT-QFbPkBURqkKuU-9eDmz7Bey_mb9Uq-DjSQDV5sFDUtl4CAasTxWpstH_98Bv7QeRdg</recordid><startdate>20170703</startdate><enddate>20170703</enddate><creator>Kang, Seung-Gul</creator><creator>Na, Kyoung-Sae</creator><creator>Choi, Jae-Won</creator><creator>Kim, Jeong-Hee</creator><creator>Son, Young-Don</creator><creator>Lee, Yu Jin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6294-7046</orcidid></search><sort><creationdate>20170703</creationdate><title>Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder</title><author>Kang, Seung-Gul ; Na, Kyoung-Sae ; Choi, Jae-Won ; Kim, Jeong-Hee ; Son, Young-Don ; Lee, Yu Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-d99a328f9a7c25a91284aaeca83928cbf101ea3305b5efa534364007e3fceaf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amygdala</topic><topic>Amygdala - pathology</topic><topic>Amygdala - physiopathology</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Case-Control Studies</topic><topic>Depressive Disorder, Major - pathology</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>fMRI</topic><topic>Functional Neuroimaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Major depressive disorder</topic><topic>Neural Pathways - pathology</topic><topic>Neural Pathways - physiopathology</topic><topic>Rest</topic><topic>Resting state functional connectivity</topic><topic>Suicide attempt</topic><topic>Suicide, Attempted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Seung-Gul</creatorcontrib><creatorcontrib>Na, Kyoung-Sae</creatorcontrib><creatorcontrib>Choi, Jae-Won</creatorcontrib><creatorcontrib>Kim, Jeong-Hee</creatorcontrib><creatorcontrib>Son, Young-Don</creatorcontrib><creatorcontrib>Lee, Yu Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Seung-Gul</au><au>Na, Kyoung-Sae</au><au>Choi, Jae-Won</au><au>Kim, Jeong-Hee</au><au>Son, Young-Don</au><au>Lee, Yu Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2017-07-03</date><risdate>2017</risdate><volume>77</volume><spage>222</spage><epage>227</epage><pages>222-227</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><abstract>In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with MDD and 19 non-suicide attempters with MDD. RSFC was compared between the two groups and the regression analyses were conducted to identify the correlation between RSFC and Scale for Suicide Ideation (SSI) scores in the suicide attempt group. Statistical significance was set at p-value (uncorrected) <0.005 with k≥28 voxels. Compared with non-suicide attempters, suicide attempters showed significantly increased RSFC of the left amygdala with the right insula and left superior orbitofrontal area, and increased RSFC of the right amygdala with the left middle temporal area. The regression analysis showed a significant correlation between the SSI total score and RSFC of the right amygdala with the right parahippocampal area in the suicide attempt group. The present RSFC findings provide evidence of a functional neural basis and will help reveal the pathophysiology underlying suicidality in subjects with MDD.
•We investigated the relationship between RSFC of the amygdala and suicide in MDD.•Suicide attempters had increased RSFC of the amygdala with several brain regions.•Significant correlation between RSFC of the amygdala and SSI was observed.•The results suggest a functional neural basis for suicidality in MDD.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>28445688</pmid><doi>10.1016/j.pnpbp.2017.04.029</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6294-7046</orcidid></addata></record> |
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| subjects | Amygdala Amygdala - pathology Amygdala - physiopathology Brain - pathology Brain - physiopathology Case-Control Studies Depressive Disorder, Major - pathology Depressive Disorder, Major - physiopathology fMRI Functional Neuroimaging Humans Magnetic Resonance Imaging Major depressive disorder Neural Pathways - pathology Neural Pathways - physiopathology Rest Resting state functional connectivity Suicide attempt Suicide, Attempted |
| title | Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder |
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