Enhanced Vector Design for Cancer Gene Therapy with Hierarchical Enhancement of Therapeutic Transgene Expression

A set of vectors for Cre recombinase-dependent expression of the hybrid suicidal FCU1 transgene was constructed, including a two-plasmid system wherein the FCU1 and Cre transgenes reside in separate vectors, and single-plasmid variants in which a single plasmid bears both transgenes. To improve the...

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Veröffentlicht in:	Human gene therapy. Part B. Methods 2017-10, Vol.28 (5), p.247-254
Hauptverfasser:	Kostina, M B, Sass, A V, Stukacheva, E A, Korobko, I V, Sverdlov, E D
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Genetic Therapy - methods Genetic Vectors - genetics Genetic Vectors - metabolism Genetic Vectors - therapeutic use Humans Integrases - genetics Neoplasms - therapy Pentosyltransferases - genetics Pentosyltransferases - metabolism Transgenes - genetics
Online-Zugang:	Volltext
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