Procyanidin, a kind of biological flavonoid, induces protective anti-tumor immunity and protects mice from lethal B16F10 challenge

Recently, increasing evidences show that procyanidin (PC) modulate immune responses in human. To evaluate adjuvant effects of PC on vaccine immune modulation and anti-tumor activity, we formulated PC with B16F10 tumor antigen as tumor vaccine to immune C57BL/6 mice and used intramuscular injection b...

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Veröffentlicht in:	International immunopharmacology 2017-06, Vol.47, p.251-258
Hauptverfasser:	Zhang, Lina, Wang, Shuang, Liu, Zeyuan, Zhang, Li, Wang, Shanzheng, Wang, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic Animals Anti-tumor Antigens, Neoplasm - immunology Biflavonoids - immunology Cancer Vaccines - immunology Catechin - immunology CD8-Positive T-Lymphocytes - immunology Cell Growth Processes Humans Immunity Immunotherapy - methods Interferon-gamma - metabolism Lymphocyte Activation Melanoma Melanoma, Experimental Mice Mice, Inbred C57BL Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Perforin - metabolism Proanthocyanidins - immunology Procyanidin Tumor Burden Tumor Necrosis Factor-alpha - metabolism Tumor vaccine
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