Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway

Glutamate-induced excitotoxicity is one of the major underlying mechanisms for neurodegenerative diseases. Efforts are being made to treat such conditions with an array of natural compounds that can modulate the release of glutamate or the underlying mechanisms associated with it. Withania somnifera...

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Veröffentlicht in:	Molecular neurobiology 2018-04, Vol.55 (4), p.2725-2739
Hauptverfasser:	Dar, Nawab John, Satti, Naresh Kumar, Dutt, Prabhu, Hamid, Abid, Ahmad, Muzamil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bcl-2-Associated X Protein - metabolism BH3 Interacting Domain Death Agonist Protein - metabolism Biomedical and Life Sciences Biomedicine Calcium - metabolism Cell Biology Cell Death - drug effects Cell Differentiation - drug effects Cell Line, Tumor Glutamic Acid - toxicity Intracellular Space - metabolism MAP Kinase Signaling System - drug effects Mice Models, Biological Neurobiology Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neurosciences Neurotoxins - toxicity Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Tumor Suppressor Protein p53 - metabolism Withanolides - pharmacology
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