Non-synaptic release of [ 3H]noradrenaline in response to oxidative stress combined with mitochondrial dysfunction in rat hippocampal slices

Brain ischemia is frequently associated with oxidative stress in the reperfusion period. It is known that noradrenaline (NA) is released in excess under energy deprivation by the sodium-dependent reversal of the monoamine carrier. However, it is not known how oxidative stress affects NA release in t...

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Veröffentlicht in:	Neuroscience 2003-01, Vol.120 (3), p.771-781
Hauptverfasser:	Milusheva, E, Sperlágh, B, Shikova, L, Baranyi, M, Tretter, L, ádám-vizi, V, Vizi, E.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Extracellular Space - metabolism Fundamental and applied biological sciences. Psychology glutamate receptors Glutamic Acid - metabolism H 2O 2 Hippocampus - drug effects Hippocampus - metabolism Hydrogen Peroxide - adverse effects Male Mitochondria - metabolism nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Norepinephrine - metabolism oligomycin Oligomycins - pharmacology Oxidative Stress Presynaptic Terminals - metabolism Rats Rats, Wistar rotenone Rotenone - pharmacology Sodium - metabolism Sodium Channel Blockers - pharmacology Tetrodotoxin - pharmacology Uncoupling Agents - pharmacology Vertebrates: nervous system and sense organs
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