Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract

The response to DNA damage was analyzed using a cell-free system consisting of Xenopus egg extract and demembranated sperm nuclei. In the absence of DNA-damaging agents, detergent-resistant accumulation of replication protein A appeared in nuclei after a 30 minute incubation, and a considerable port...

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Veröffentlicht in:	Journal of cell science 2002-08, Vol.115 (Pt 15), p.3159-3169
Hauptverfasser:	Kobayashi, Takayuki, Tada, Shusuke, Tsuyama, Takashi, Murofushi, Hiromu, Seki, Masayuki, Enomoto, Takemi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins Biotin - analogs & derivatives Biotin - pharmacology Caffeine - pharmacology Camptothecin - pharmacology Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cell Cycle Proteins - pharmacology Cell Extracts Cell Nucleus - drug effects Cell Nucleus - genetics Cell Nucleus - metabolism Cell-Free System - drug effects Cell-Free System - metabolism Deoxyuracil Nucleotides - pharmacology DNA Damage - drug effects DNA Damage - genetics DNA Repair - drug effects DNA Repair - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - drug effects Eukaryotic Cells - drug effects Eukaryotic Cells - metabolism Female Freshwater Geminin Genes, cdc - drug effects Genes, cdc - physiology Male Oocytes Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - metabolism Replication Protein A Site-Specific DNA-Methyltransferase (Adenine-Specific) - pharmacology Spermatozoa Tumor Suppressor Proteins Xenopus Xenopus laevis Xenopus Proteins
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