Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake

Guanosine (GUO) has been shown to stimulate glutamate uptake in primary astrocyte cultures. The purpose of this study was to determine the effect and specificity of guanine- or adenine-based purines on glutamate and GABA uptake in cultured astrocytes. Stimulatory effect on glutamate uptake was obser...

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Veröffentlicht in:	Brain research 2003-05, Vol.972 (1), p.84-89
Hauptverfasser:	dos Santos Frizzo, Marcos Emı&#x0301, lio, Antunes Soares, Félix Alexandre, Dall’Onder, Leonara Patrı&#x0301, cia, Lara, Diogo Rizzato, Swanson, Raymond A., Souza, Diogo Onofre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - pharmacology Animals Animals, Newborn Astrocyte Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Cell culture Cells, Cultured Chromatography, High Pressure Liquid - instrumentation Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors - pharmacology Extracellular Space - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Glutamate uptake Glutamic Acid - metabolism Guanine - metabolism Guanosine Guanosine - pharmacology Guanosine Monophosphate - pharmacology Guanosine Triphosphate - pharmacology Isolated neuron and nerve. Neuroglia Nucleotide Purines Rats Rats, Wistar Vertebrates: nervous system and sense organs
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