The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo

Brain inflammatory processes underlie the pathogenesis of Alzheimer’s disease, and non-steroidal anti-inflammatory drugs have a protective effect in the disease. The aim of this work was to study in vivo whether attenuation of brain inflammatory response to excitotoxic insult by the selective cycloo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2003-01, Vol.117 (4), p.909-919
Hauptverfasser:	Scali, C, Giovannini, M.G, Prosperi, C, Bellucci, A, Pepeu, G, Casamenti, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - physiopathology Animals Astrocytes - drug effects Astrocytes - enzymology Biological and medical sciences Brain - drug effects Brain - enzymology Brain - physiopathology Cell Death - drug effects Cell Death - physiology Choline O-Acetyltransferase - drug effects Choline O-Acetyltransferase - metabolism cholinergic degeneration Cholinergic Fibers - drug effects Cholinergic Fibers - enzymology Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Encephalitis - drug therapy Encephalitis - enzymology Encephalitis - physiopathology glia reactivity Gliosis - drug therapy Gliosis - enzymology Gliosis - prevention & control Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Lactones - pharmacology Male Medical sciences Microglia - drug effects Microglia - enzymology Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Nerve Degeneration - drug therapy Nerve Degeneration - enzymology Nerve Degeneration - prevention & control Neurons - drug effects Neurons - enzymology Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Neurotoxins - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases p38-mitogen-activated protein kinase Pharmacology. Drug treatments Phosphorylation - drug effects Prostaglandin-Endoperoxide Synthases - metabolism quisqualic acid Quisqualic Acid - antagonists & inhibitors rat Rats Rats, Wistar rofecoxib Sulfones
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!