Identification of multiple sources of the acidic charge variants in an IgG1 monoclonal antibody

Charge variants, especially acidic charge variants, of recombinant monoclonal antibodies are the major critical quality attributes in the biotechnology industry due to their potential influence on stability and biological activity. The chemical properties of the acidic charge variants have been chal...

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Veröffentlicht in:	Applied microbiology and biotechnology 2017-07, Vol.101 (14), p.5627-5638
Hauptverfasser:	Miao, Shiwei, Xie, Panpan, Zou, Mao, Fan, Li, Liu, Xuping, Zhou, Yan, Zhao, Liang, Ding, Ding, Wang, Haibin, Tan, Wen-Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Agglomeration Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibody Affinity Batteries Binding Biological activity Biological properties Biomedical and Life Sciences Biotechnological Products and Process Engineering Biotechnology Cation exchange Cation exchanging Cell culture Chemical properties CHO Cells Chromatography Chromatography, High Pressure Liquid Chromatography, Ion Exchange Cricetinae Cricetulus Deamination Digestion Disulfides - chemistry Enzyme-Linked Immunosorbent Assay Galactosidase Genetic aspects Genetic variation Heterogeneity Hydrogen-Ion Concentration Immunoglobulin E Immunoglobulin G Immunoglobulin G - chemistry Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulins Life Sciences Mass Spectrometry Microbial Genetics and Genomics Microbiology Molecular weight Monoclonal antibodies Observations Physiological aspects Product development Quality management Recombinant Proteins - chemistry Surface Plasmon Resonance
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