Prospective open uncontrolled phase I study to define a well-tolerated dose of oral artesunate as add-on therapy in patients with metastatic breast cancer (ARTIC M33/2)

Purpose The antimalarial drug artesunate (ART) is a promising candidate for cancer treatment as it displays anticancer effects in various models. While in short-term treatment of malaria, an excellent safety profile has been found for ART, the potential long-term treatment of cancer patients demands...

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Veröffentlicht in:	Breast cancer research and treatment 2017-07, Vol.164 (2), p.359-369
Hauptverfasser:	von Hagens, Cornelia, Walter-Sack, Ingeborg, Goeckenjan, Maren, Osburg, Julia, Storch-Hagenlocher, Brigitte, Sertel, Serkan, Elsässer, Michael, Remppis, Bjoern Andrew, Edler, Lutz, Munzinger, Judith, Efferth, Thomas, Schneeweiss, Andreas, Strowitzki, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anemia Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Artemisinins - administration & dosage Artemisinins - adverse effects Artesunate Asthenia Breast cancer Breast Neoplasms - drug therapy Cancer metastasis Cancer patients Cancer research Cancer treatment Care and treatment Clinical Trial Clinical trials Complications and side effects Drug Administration Schedule Female Humans Leukopenia Malaria Maximum Tolerated Dose Medicine Medicine & Public Health Metastases Metastasis Middle Aged Neoplasm Metastasis Neutropenia Oncology Prospective Studies Reticulocytes Treatment Outcome
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