Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies
Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha‐synuclein in precerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait, and impaired balance, which may be associated with cerebellar dysfunction. Therefore, we sc...
Gespeichert in:
| Veröffentlicht in: | Annals of neurology 2017-06, Vol.81 (6), p.898-903 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 903 |
|---|---|
| container_issue | 6 |
| container_start_page | 898 |
| container_title | Annals of neurology |
| container_volume | 81 |
| creator | Seidel, Kay Bouzrou, Mohamed Heidemann, Nina Krüger, Rejko Schöls, Ludger den Dunnen, Wilfred F. A. Korf, Horst‐Werner Rüb, Udo |
| description | Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha‐synuclein in precerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait, and impaired balance, which may be associated with cerebellar dysfunction. Therefore, we screened the cerebella of 12 patients with alpha‐synucleinopathies for neuropathological changes. Cerebellar nuclei and neighboring white matter displayed numerous aggregates, whereas lobules were mildly affected. Cerebellar aggregation pathology may suggest a prionlike spread originating from affected precerebellar structures, and the high homogeneity between patients with dementia with Lewy bodies and Parkinson disease shows that both diseases likely belong to the same neuropathological spectrum. Ann Neurol 2017;81:898–903 |
| doi_str_mv | 10.1002/ana.24937 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1891891448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1891891448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3887-18873487b2f1f11b335e295ad9cffb30670ea8ce47418d76aa4fc4a501bdee073</originalsourceid><addsrcrecordid>eNp1kF1LwzAUhoMobk4v_AMS8EYvuuU06ZpejuEXDN2FXoe0PWWZbTqbdWP_3mydXgjCISeBJw8vLyHXwIbAWDjSVg9DkfD4hPQh4hBI_zolfcbHIoiAix65cG7JGEvGwM5JL5SCJ_7eJ_MXu6nLDVZo17Qu6HqBNMMGUyzLtqLG0rluPo11taW5cagdUm1zmh9-GE23Zr2gM9zuaFrnBt0lOSt06fDquAfk4_HhffoczN6eXqaTWZBxKeMA_MGFjNOwgAIg5TzCMIl0nmRFkXI2jhlqmaGIBcg8HmstikzoiEGaI7KYD8hd51019VeLbq0q4zKfWlusW6dAJvsRQnr09g-6rNvG-nQKEgAWCxnthfcdlTW1cw0WatWYSjc7BUzta1a-ZnWo2bM3R2ObVpj_kj-9emDUAVtT4u5_k5q8TjrlN3oZhZ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1911074857</pqid></control><display><type>article</type><title>Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Seidel, Kay ; Bouzrou, Mohamed ; Heidemann, Nina ; Krüger, Rejko ; Schöls, Ludger ; den Dunnen, Wilfred F. A. ; Korf, Horst‐Werner ; Rüb, Udo</creator><creatorcontrib>Seidel, Kay ; Bouzrou, Mohamed ; Heidemann, Nina ; Krüger, Rejko ; Schöls, Ludger ; den Dunnen, Wilfred F. A. ; Korf, Horst‐Werner ; Rüb, Udo</creatorcontrib><description>Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha‐synuclein in precerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait, and impaired balance, which may be associated with cerebellar dysfunction. Therefore, we screened the cerebella of 12 patients with alpha‐synucleinopathies for neuropathological changes. Cerebellar nuclei and neighboring white matter displayed numerous aggregates, whereas lobules were mildly affected. Cerebellar aggregation pathology may suggest a prionlike spread originating from affected precerebellar structures, and the high homogeneity between patients with dementia with Lewy bodies and Parkinson disease shows that both diseases likely belong to the same neuropathological spectrum. Ann Neurol 2017;81:898–903</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.24937</identifier><identifier>PMID: 28439961</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Agglomeration ; Aggregates ; alpha-Synuclein - metabolism ; Balance ; Brain stem ; Cerebellar Diseases - metabolism ; Cerebellar Diseases - pathology ; Cerebellum ; Dementia ; Dementia disorders ; Gait ; Homogeneity ; Humans ; Lewy bodies ; Lewy Body Disease - metabolism ; Lewy Body Disease - pathology ; Movement disorders ; Neurodegenerative diseases ; Neuropathology ; Nuclei ; Parkinson Disease - metabolism ; Parkinson Disease - pathology ; Parkinson's disease ; Patients ; Substantia alba ; Synuclein ; Tremor</subject><ispartof>Annals of neurology, 2017-06, Vol.81 (6), p.898-903</ispartof><rights>2017 American Neurological Association</rights><rights>2017 American Neurological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-18873487b2f1f11b335e295ad9cffb30670ea8ce47418d76aa4fc4a501bdee073</citedby><cites>FETCH-LOGICAL-c3887-18873487b2f1f11b335e295ad9cffb30670ea8ce47418d76aa4fc4a501bdee073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.24937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.24937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28439961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seidel, Kay</creatorcontrib><creatorcontrib>Bouzrou, Mohamed</creatorcontrib><creatorcontrib>Heidemann, Nina</creatorcontrib><creatorcontrib>Krüger, Rejko</creatorcontrib><creatorcontrib>Schöls, Ludger</creatorcontrib><creatorcontrib>den Dunnen, Wilfred F. A.</creatorcontrib><creatorcontrib>Korf, Horst‐Werner</creatorcontrib><creatorcontrib>Rüb, Udo</creatorcontrib><title>Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha‐synuclein in precerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait, and impaired balance, which may be associated with cerebellar dysfunction. Therefore, we screened the cerebella of 12 patients with alpha‐synucleinopathies for neuropathological changes. Cerebellar nuclei and neighboring white matter displayed numerous aggregates, whereas lobules were mildly affected. Cerebellar aggregation pathology may suggest a prionlike spread originating from affected precerebellar structures, and the high homogeneity between patients with dementia with Lewy bodies and Parkinson disease shows that both diseases likely belong to the same neuropathological spectrum. Ann Neurol 2017;81:898–903</description><subject>Agglomeration</subject><subject>Aggregates</subject><subject>alpha-Synuclein - metabolism</subject><subject>Balance</subject><subject>Brain stem</subject><subject>Cerebellar Diseases - metabolism</subject><subject>Cerebellar Diseases - pathology</subject><subject>Cerebellum</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Gait</subject><subject>Homogeneity</subject><subject>Humans</subject><subject>Lewy bodies</subject><subject>Lewy Body Disease - metabolism</subject><subject>Lewy Body Disease - pathology</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neuropathology</subject><subject>Nuclei</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Substantia alba</subject><subject>Synuclein</subject><subject>Tremor</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMobk4v_AMS8EYvuuU06ZpejuEXDN2FXoe0PWWZbTqbdWP_3mydXgjCISeBJw8vLyHXwIbAWDjSVg9DkfD4hPQh4hBI_zolfcbHIoiAix65cG7JGEvGwM5JL5SCJ_7eJ_MXu6nLDVZo17Qu6HqBNMMGUyzLtqLG0rluPo11taW5cagdUm1zmh9-GE23Zr2gM9zuaFrnBt0lOSt06fDquAfk4_HhffoczN6eXqaTWZBxKeMA_MGFjNOwgAIg5TzCMIl0nmRFkXI2jhlqmaGIBcg8HmstikzoiEGaI7KYD8hd51019VeLbq0q4zKfWlusW6dAJvsRQnr09g-6rNvG-nQKEgAWCxnthfcdlTW1cw0WatWYSjc7BUzta1a-ZnWo2bM3R2ObVpj_kj-9emDUAVtT4u5_k5q8TjrlN3oZhZ4</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Seidel, Kay</creator><creator>Bouzrou, Mohamed</creator><creator>Heidemann, Nina</creator><creator>Krüger, Rejko</creator><creator>Schöls, Ludger</creator><creator>den Dunnen, Wilfred F. A.</creator><creator>Korf, Horst‐Werner</creator><creator>Rüb, Udo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies</title><author>Seidel, Kay ; Bouzrou, Mohamed ; Heidemann, Nina ; Krüger, Rejko ; Schöls, Ludger ; den Dunnen, Wilfred F. A. ; Korf, Horst‐Werner ; Rüb, Udo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-18873487b2f1f11b335e295ad9cffb30670ea8ce47418d76aa4fc4a501bdee073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Agglomeration</topic><topic>Aggregates</topic><topic>alpha-Synuclein - metabolism</topic><topic>Balance</topic><topic>Brain stem</topic><topic>Cerebellar Diseases - metabolism</topic><topic>Cerebellar Diseases - pathology</topic><topic>Cerebellum</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Gait</topic><topic>Homogeneity</topic><topic>Humans</topic><topic>Lewy bodies</topic><topic>Lewy Body Disease - metabolism</topic><topic>Lewy Body Disease - pathology</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neuropathology</topic><topic>Nuclei</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Substantia alba</topic><topic>Synuclein</topic><topic>Tremor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seidel, Kay</creatorcontrib><creatorcontrib>Bouzrou, Mohamed</creatorcontrib><creatorcontrib>Heidemann, Nina</creatorcontrib><creatorcontrib>Krüger, Rejko</creatorcontrib><creatorcontrib>Schöls, Ludger</creatorcontrib><creatorcontrib>den Dunnen, Wilfred F. A.</creatorcontrib><creatorcontrib>Korf, Horst‐Werner</creatorcontrib><creatorcontrib>Rüb, Udo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seidel, Kay</au><au>Bouzrou, Mohamed</au><au>Heidemann, Nina</au><au>Krüger, Rejko</au><au>Schöls, Ludger</au><au>den Dunnen, Wilfred F. A.</au><au>Korf, Horst‐Werner</au><au>Rüb, Udo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>81</volume><issue>6</issue><spage>898</spage><epage>903</epage><pages>898-903</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>Brains from patients with Parkinson disease or dementia with Lewy bodies show aggregation of alpha‐synuclein in precerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait, and impaired balance, which may be associated with cerebellar dysfunction. Therefore, we screened the cerebella of 12 patients with alpha‐synucleinopathies for neuropathological changes. Cerebellar nuclei and neighboring white matter displayed numerous aggregates, whereas lobules were mildly affected. Cerebellar aggregation pathology may suggest a prionlike spread originating from affected precerebellar structures, and the high homogeneity between patients with dementia with Lewy bodies and Parkinson disease shows that both diseases likely belong to the same neuropathological spectrum. Ann Neurol 2017;81:898–903</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28439961</pmid><doi>10.1002/ana.24937</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 2017-06, Vol.81 (6), p.898-903 |
| issn | 0364-5134 1531-8249 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1891891448 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Agglomeration Aggregates alpha-Synuclein - metabolism Balance Brain stem Cerebellar Diseases - metabolism Cerebellar Diseases - pathology Cerebellum Dementia Dementia disorders Gait Homogeneity Humans Lewy bodies Lewy Body Disease - metabolism Lewy Body Disease - pathology Movement disorders Neurodegenerative diseases Neuropathology Nuclei Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Patients Substantia alba Synuclein Tremor |
| title | Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T03%3A48%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Involvement%20of%20the%20cerebellum%20in%20Parkinson%20disease%20and%20dementia%20with%20Lewy%20bodies&rft.jtitle=Annals%20of%20neurology&rft.au=Seidel,%20Kay&rft.date=2017-06&rft.volume=81&rft.issue=6&rft.spage=898&rft.epage=903&rft.pages=898-903&rft.issn=0364-5134&rft.eissn=1531-8249&rft_id=info:doi/10.1002/ana.24937&rft_dat=%3Cproquest_cross%3E1891891448%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1911074857&rft_id=info:pmid/28439961&rfr_iscdi=true |