Altered Gray and White Matter Microstructure in Cushing’s Disease: A Diffusional Kurtosis Imaging Study

Highlights • This is the first study demonstrates the microstructural properties in both white matter and gray matter of patients with hypercortisolism. • This is also the first DKI study of patients with hypercortisolism. • Previous structural studies of CD/CS patients mainly evaluated the hippocam...

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Veröffentlicht in:	Brain research 2017-06, Vol.1665, p.80-87
Hauptverfasser:	JIANG, Hong, HE, Na-Ying, SUN, Yu-Hao, JIAN, Fang-Fang, BIAN, Liu-Guan, SHEN, Jian-Kang, YAN, Fu-Hua, PAN, Si-JIAN, SUN, Qing-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Cognitive Dysfunction - diagnosis Cross-Sectional Studies Cushing’s disease Diffusion Magnetic Resonance Imaging - methods Diffusion Tensor Imaging - methods DKI Female Gray Matter - diagnostic imaging Humans Image Interpretation, Computer-Assisted - methods Male Microstructure alteration Middle Aged Neurology White Matter - diagnostic imaging
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Beschreibung
Zusammenfassung:	Highlights • This is the first study demonstrates the microstructural properties in both white matter and gray matter of patients with hypercortisolism. • This is also the first DKI study of patients with hypercortisolism. • Previous structural studies of CD/CS patients mainly evaluated the hippocampus. This is the first study demonstrated the alterations in the whole MTL of patients with hypercortisolism.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.04.007