Comparison of interferon-γ release assays, QuantiFERON TB-GIT and T-Spot.TB, in renal transplantation
Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and progressing to active tuberculosis (TB). This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ relea...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2017-07, Vol.23 (7), p.468-473 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Ishikawa, Satoru Igari, Hidetoshi Akutsu, Naotake Tsuyuzaki, Mizue Aoyama, Hiromichi Hasegawa, Masayuki Otsuki, Kazunori Maruyama, Michihiro Saigo, Kenichi Suzuki, Kiminori Yamagishi, Fumio |
| description | Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and progressing to active tuberculosis (TB). This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ release assays (IGRAs), QuantiFERON®-TB Gold in Tube (QFT) and T-SPOT®.TB (TSPOT), in patients after renal transplantation for detecting latent TB infection (LTBI). Total 92 renal transplant recipients (median age 46 years, range 17–75) were prospectively enrolled, and QFT and TSPOT were concurrently examined. Total subjects were 92 patients (median age 46 years, range 17–75). The positive rate in QFT and TSPOT were 6.5% (95% confidence interval (CI) 3.0–13.5) and 2.2% (95% CI 1.0–7.6), respectively. There was a significant difference in IGRAs positivity (P |
| doi_str_mv | 10.1016/j.jiac.2017.04.002 |
| format | Article |
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This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ release assays (IGRAs), QuantiFERON®-TB Gold in Tube (QFT) and T-SPOT®.TB (TSPOT), in patients after renal transplantation for detecting latent TB infection (LTBI). Total 92 renal transplant recipients (median age 46 years, range 17–75) were prospectively enrolled, and QFT and TSPOT were concurrently examined. Total subjects were 92 patients (median age 46 years, range 17–75). The positive rate in QFT and TSPOT were 6.5% (95% confidence interval (CI) 3.0–13.5) and 2.2% (95% CI 1.0–7.6), respectively. There was a significant difference in IGRAs positivity (P < 0.05). The negative rate in QFT and TSPOT were 91.3% (95% CI 83.8–95.5) and 95.7% (95% CI 89.3–98.3), respectively. There was no significant difference in IGRAs negativity. No patients among either IGRAs negative patients developed active TB during median follow-up of 994 days. Neither QFT nor TSPOT reaches estimated TB infection rate in Japan, especially elderly recipients aged 60 year-old or more. Therefore, both IGRAs might underestimate LTBI owing to immune suppressive therapy and aging. Physicians for renal transplantation need to understand the characteristics of both IGRAs and pay attention to the possibility of developing active TB even in patients of negative IGRAs results.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1016/j.jiac.2017.04.002</identifier><identifier>PMID: 28438462</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Immune suppressive condition ; Immunocompromised Host ; Interferon-gamma - immunology ; Interferon-gamma - metabolism ; Interferon-gamma Release Tests - methods ; Interferon-gamma Release Tests - standards ; Interferon-γ release assay ; Kidney Transplantation ; Latent Tuberculosis - diagnosis ; Latent tuberculosis infection ; Male ; Middle Aged ; Renal transplantation ; Young Adult</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2017-07, Vol.23 (7), p.468-473</ispartof><rights>2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>Copyright © 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28438462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishikawa, Satoru</creatorcontrib><creatorcontrib>Igari, Hidetoshi</creatorcontrib><creatorcontrib>Akutsu, Naotake</creatorcontrib><creatorcontrib>Tsuyuzaki, Mizue</creatorcontrib><creatorcontrib>Aoyama, Hiromichi</creatorcontrib><creatorcontrib>Hasegawa, Masayuki</creatorcontrib><creatorcontrib>Otsuki, Kazunori</creatorcontrib><creatorcontrib>Maruyama, Michihiro</creatorcontrib><creatorcontrib>Saigo, Kenichi</creatorcontrib><creatorcontrib>Suzuki, Kiminori</creatorcontrib><creatorcontrib>Yamagishi, Fumio</creatorcontrib><title>Comparison of interferon-γ release assays, QuantiFERON TB-GIT and T-Spot.TB, in renal transplantation</title><title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><addtitle>J Infect Chemother</addtitle><description>Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and progressing to active tuberculosis (TB). This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ release assays (IGRAs), QuantiFERON®-TB Gold in Tube (QFT) and T-SPOT®.TB (TSPOT), in patients after renal transplantation for detecting latent TB infection (LTBI). Total 92 renal transplant recipients (median age 46 years, range 17–75) were prospectively enrolled, and QFT and TSPOT were concurrently examined. Total subjects were 92 patients (median age 46 years, range 17–75). The positive rate in QFT and TSPOT were 6.5% (95% confidence interval (CI) 3.0–13.5) and 2.2% (95% CI 1.0–7.6), respectively. There was a significant difference in IGRAs positivity (P < 0.05). The negative rate in QFT and TSPOT were 91.3% (95% CI 83.8–95.5) and 95.7% (95% CI 89.3–98.3), respectively. There was no significant difference in IGRAs negativity. No patients among either IGRAs negative patients developed active TB during median follow-up of 994 days. Neither QFT nor TSPOT reaches estimated TB infection rate in Japan, especially elderly recipients aged 60 year-old or more. Therefore, both IGRAs might underestimate LTBI owing to immune suppressive therapy and aging. Physicians for renal transplantation need to understand the characteristics of both IGRAs and pay attention to the possibility of developing active TB even in patients of negative IGRAs results.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Immune suppressive condition</subject><subject>Immunocompromised Host</subject><subject>Interferon-gamma - immunology</subject><subject>Interferon-gamma - metabolism</subject><subject>Interferon-gamma Release Tests - methods</subject><subject>Interferon-gamma Release Tests - standards</subject><subject>Interferon-γ release assay</subject><subject>Kidney Transplantation</subject><subject>Latent Tuberculosis - diagnosis</subject><subject>Latent tuberculosis infection</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal transplantation</subject><subject>Young Adult</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kc1OGzEQx62KquGjL9BD5SMHduuveB2pF4ggIKEiYJG4WV57VnK0sRd7U4nn6nvwTDhKepo5_P6jmfkh9IOSmhIqf63rtTe2ZoQ2NRE1IewLOqaCN1XTKHJUei5oxRl9naGTnNekgHOlvqEZU4IrIdkx6pdxM5rkcww49tiHCVIPKYbq4x9OMIDJgE3O5j1f4MetCZO_uX56-IPbq2p112ITHG6r5zFOdXt1UfIlFMyAp2RCHofCm8nHcIa-9mbI8P1QT9HLzXW7vK3uH1Z3y8v7CphSU2WauZNSUjd3XcfJnDouuSVWWsEkYcJ2nXJM9AXqgVPROAWULHg5rG-co_wUne_njim-bSFPeuOzhaEsAnGbNVULqtSCSVXQnwd0223A6TH5jUnv-v9vCvB7D0BZ-K-HpLP1ECw4n8BO2kWvKdE7FXqtdyr0ToUmQhcV_BOmdns7</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Ishikawa, Satoru</creator><creator>Igari, Hidetoshi</creator><creator>Akutsu, Naotake</creator><creator>Tsuyuzaki, Mizue</creator><creator>Aoyama, Hiromichi</creator><creator>Hasegawa, Masayuki</creator><creator>Otsuki, Kazunori</creator><creator>Maruyama, Michihiro</creator><creator>Saigo, Kenichi</creator><creator>Suzuki, Kiminori</creator><creator>Yamagishi, Fumio</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20170701</creationdate><title>Comparison of interferon-γ release assays, QuantiFERON TB-GIT and T-Spot.TB, in renal transplantation</title><author>Ishikawa, Satoru ; Igari, Hidetoshi ; Akutsu, Naotake ; Tsuyuzaki, Mizue ; Aoyama, Hiromichi ; Hasegawa, Masayuki ; Otsuki, Kazunori ; Maruyama, Michihiro ; Saigo, Kenichi ; Suzuki, Kiminori ; Yamagishi, Fumio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e288t-a75d6661d5dbb3051d363c0c6c426024cbb8d24fd66fe3147d8e1093017f7dd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Immune suppressive condition</topic><topic>Immunocompromised Host</topic><topic>Interferon-gamma - immunology</topic><topic>Interferon-gamma - metabolism</topic><topic>Interferon-gamma Release Tests - methods</topic><topic>Interferon-gamma Release Tests - standards</topic><topic>Interferon-γ release assay</topic><topic>Kidney Transplantation</topic><topic>Latent Tuberculosis - diagnosis</topic><topic>Latent tuberculosis infection</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Renal transplantation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishikawa, Satoru</creatorcontrib><creatorcontrib>Igari, Hidetoshi</creatorcontrib><creatorcontrib>Akutsu, Naotake</creatorcontrib><creatorcontrib>Tsuyuzaki, Mizue</creatorcontrib><creatorcontrib>Aoyama, Hiromichi</creatorcontrib><creatorcontrib>Hasegawa, Masayuki</creatorcontrib><creatorcontrib>Otsuki, Kazunori</creatorcontrib><creatorcontrib>Maruyama, Michihiro</creatorcontrib><creatorcontrib>Saigo, Kenichi</creatorcontrib><creatorcontrib>Suzuki, Kiminori</creatorcontrib><creatorcontrib>Yamagishi, Fumio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishikawa, Satoru</au><au>Igari, Hidetoshi</au><au>Akutsu, Naotake</au><au>Tsuyuzaki, Mizue</au><au>Aoyama, Hiromichi</au><au>Hasegawa, Masayuki</au><au>Otsuki, Kazunori</au><au>Maruyama, Michihiro</au><au>Saigo, Kenichi</au><au>Suzuki, Kiminori</au><au>Yamagishi, Fumio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of interferon-γ release assays, QuantiFERON TB-GIT and T-Spot.TB, in renal transplantation</atitle><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle><addtitle>J Infect Chemother</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>23</volume><issue>7</issue><spage>468</spage><epage>473</epage><pages>468-473</pages><issn>1341-321X</issn><eissn>1437-7780</eissn><abstract>Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and progressing to active tuberculosis (TB). This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ release assays (IGRAs), QuantiFERON®-TB Gold in Tube (QFT) and T-SPOT®.TB (TSPOT), in patients after renal transplantation for detecting latent TB infection (LTBI). Total 92 renal transplant recipients (median age 46 years, range 17–75) were prospectively enrolled, and QFT and TSPOT were concurrently examined. Total subjects were 92 patients (median age 46 years, range 17–75). The positive rate in QFT and TSPOT were 6.5% (95% confidence interval (CI) 3.0–13.5) and 2.2% (95% CI 1.0–7.6), respectively. There was a significant difference in IGRAs positivity (P < 0.05). The negative rate in QFT and TSPOT were 91.3% (95% CI 83.8–95.5) and 95.7% (95% CI 89.3–98.3), respectively. There was no significant difference in IGRAs negativity. No patients among either IGRAs negative patients developed active TB during median follow-up of 994 days. Neither QFT nor TSPOT reaches estimated TB infection rate in Japan, especially elderly recipients aged 60 year-old or more. Therefore, both IGRAs might underestimate LTBI owing to immune suppressive therapy and aging. Physicians for renal transplantation need to understand the characteristics of both IGRAs and pay attention to the possibility of developing active TB even in patients of negative IGRAs results.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>28438462</pmid><doi>10.1016/j.jiac.2017.04.002</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2017-07, Vol.23 (7), p.468-473 |
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| subjects | Adolescent Adult Aged Cross-Sectional Studies Female Humans Immune suppressive condition Immunocompromised Host Interferon-gamma - immunology Interferon-gamma - metabolism Interferon-gamma Release Tests - methods Interferon-gamma Release Tests - standards Interferon-γ release assay Kidney Transplantation Latent Tuberculosis - diagnosis Latent tuberculosis infection Male Middle Aged Renal transplantation Young Adult |
| title | Comparison of interferon-γ release assays, QuantiFERON TB-GIT and T-Spot.TB, in renal transplantation |
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