Elevated intraocular pressure increases melatonin levels in the aqueous humour
Purpose To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2017-05, Vol.95 (3), p.e185-e189 |
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| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | Alkozi, Hanan Sánchez‐Naves, Juan Lara, Maria Jesús Perez Carracedo, Gonzalo Fonseca, Begoña Martinez‐Aguila, Alejandro Pintor, Jesús |
| description | Purpose
To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma.
Methods
A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided into normotensive patients, with IOP below 21 mmHg (n = 23), and hypertensive patients, with IOP > 21 mmHg (n = 14). Glaucomatous DBA/2J (n = 6) and control C57BL/6J (n = 6) mice presenting 3 and 12 months of age for each strain were also used. Human and mice aqueous humours were aspirated using a 30‐gauge Rycroft cannula on a tuberculin syringe and further processed to quantify melatonin by high‐performance liquid chromatography analysis.
Results
Melatonin levels in normotensive patients (IOP below 21 mmHg) presented values as medians (first quartile; third quartile) of 14.62 (5.38;37.99) ng/ml (n = 23), while hypertensive patients (IOP above 21 mmHg) showed melatonin concentrations of 46.63 (10.28; 167.28) ng/ml (n = 14; p |
| doi_str_mv | 10.1111/aos.13253 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1891886638</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859738646</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4213-717bc933975f5b8bbc1b699ab8a368bc68a0bb979c1d2e61b0dc073ec617146f3</originalsourceid><addsrcrecordid>eNqNkctKAzEUhoMotlYXvoAMuNHF2MlkcluWUi9Q7EIFdyFJT-mUudRkRunbm3ZqF4JgNgnnfPk4hx-hS5zc4XCGuvZ3mKSUHKE-5pTGhDNxfHjT9x46836VJAwzlp2iXsqppFxkffQ8KeBTNzCP8qpxurZtoV20duB96yAUrQPtwUclFLqpq7yKwgcofGhFzRIi_dFC3fpo2ZZ1687RyUIXHi729wC93U9ex4_xdPbwNB5NY5ulmMQcc2MlIZLTBTXCGIsNk1IboQkTxjKhE2MklxbPU2DYJHObcAKWYY4ztiADdNN5164OA_hGlbm3UBS62k6jsJBYCMaI-AdKJSeCZSyg17_QVdipCouonS0JPhqo246yrvbewUKtXV5qt1E4Uds8VMhD7fII7NXe2JoS5gfyJ4AADDvgKy9g87dJjWYvnfIbhamUKA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1886606385</pqid></control><display><type>article</type><title>Elevated intraocular pressure increases melatonin levels in the aqueous humour</title><source>MEDLINE</source><source>Wiley Blackwell Single Titles</source><source>Wiley Online Library Free Content</source><creator>Alkozi, Hanan ; Sánchez‐Naves, Juan ; Lara, Maria Jesús Perez ; Carracedo, Gonzalo ; Fonseca, Begoña ; Martinez‐Aguila, Alejandro ; Pintor, Jesús</creator><creatorcontrib>Alkozi, Hanan ; Sánchez‐Naves, Juan ; Lara, Maria Jesús Perez ; Carracedo, Gonzalo ; Fonseca, Begoña ; Martinez‐Aguila, Alejandro ; Pintor, Jesús</creatorcontrib><description>Purpose
To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma.
Methods
A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided into normotensive patients, with IOP below 21 mmHg (n = 23), and hypertensive patients, with IOP > 21 mmHg (n = 14). Glaucomatous DBA/2J (n = 6) and control C57BL/6J (n = 6) mice presenting 3 and 12 months of age for each strain were also used. Human and mice aqueous humours were aspirated using a 30‐gauge Rycroft cannula on a tuberculin syringe and further processed to quantify melatonin by high‐performance liquid chromatography analysis.
Results
Melatonin levels in normotensive patients (IOP below 21 mmHg) presented values as medians (first quartile; third quartile) of 14.62 (5.38;37.99) ng/ml (n = 23), while hypertensive patients (IOP above 21 mmHg) showed melatonin concentrations of 46.63 (10.28; 167.28) ng/ml (n = 14; p < 0.039). Glaucoma mice presented melatonin values of 0.37 (0.34; 0.59) ng/ml (at 3 months of age, before the pathology starts), which increased to 1.55 (0.94; 1.88) ng/ml (at 12 months of age, when the pathology is fully developed and IOP is maximum; n = 6, p < 0.001). Control mice did not significantly modified melatonin concentrations between 3 and 12 months of age.
Conclusion
Patients with high IOP present increased concentrations of melatonin in their aqueous humour compared to normotensive patients. This has been confirmed in a glaucomatous animal model in which it has been possible to see a correlation between the development of the pathology, with an increase in IOP, and a concomitant elevation of melatonin in the aqueous humour.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.13253</identifier><identifier>PMID: 27595784</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Animals ; Aqueous Humor - metabolism ; aqueous humour ; Biomarkers - metabolism ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Female ; glaucoma ; Glaucoma - metabolism ; Glaucoma - physiopathology ; high‐performance liquid chromatography ; Humans ; Intraocular Pressure - physiology ; Male ; melatonin ; Melatonin - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Middle Aged ; Ocular Hypertension - metabolism ; Ocular Hypertension - physiopathology ; Ophthalmology</subject><ispartof>Acta ophthalmologica (Oxford, England), 2017-05, Vol.95 (3), p.e185-e189</ispartof><rights>2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4213-717bc933975f5b8bbc1b699ab8a368bc68a0bb979c1d2e61b0dc073ec617146f3</citedby><cites>FETCH-LOGICAL-c4213-717bc933975f5b8bbc1b699ab8a368bc68a0bb979c1d2e61b0dc073ec617146f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.13253$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.13253$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27595784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alkozi, Hanan</creatorcontrib><creatorcontrib>Sánchez‐Naves, Juan</creatorcontrib><creatorcontrib>Lara, Maria Jesús Perez</creatorcontrib><creatorcontrib>Carracedo, Gonzalo</creatorcontrib><creatorcontrib>Fonseca, Begoña</creatorcontrib><creatorcontrib>Martinez‐Aguila, Alejandro</creatorcontrib><creatorcontrib>Pintor, Jesús</creatorcontrib><title>Elevated intraocular pressure increases melatonin levels in the aqueous humour</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma.
Methods
A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided into normotensive patients, with IOP below 21 mmHg (n = 23), and hypertensive patients, with IOP > 21 mmHg (n = 14). Glaucomatous DBA/2J (n = 6) and control C57BL/6J (n = 6) mice presenting 3 and 12 months of age for each strain were also used. Human and mice aqueous humours were aspirated using a 30‐gauge Rycroft cannula on a tuberculin syringe and further processed to quantify melatonin by high‐performance liquid chromatography analysis.
Results
Melatonin levels in normotensive patients (IOP below 21 mmHg) presented values as medians (first quartile; third quartile) of 14.62 (5.38;37.99) ng/ml (n = 23), while hypertensive patients (IOP above 21 mmHg) showed melatonin concentrations of 46.63 (10.28; 167.28) ng/ml (n = 14; p < 0.039). Glaucoma mice presented melatonin values of 0.37 (0.34; 0.59) ng/ml (at 3 months of age, before the pathology starts), which increased to 1.55 (0.94; 1.88) ng/ml (at 12 months of age, when the pathology is fully developed and IOP is maximum; n = 6, p < 0.001). Control mice did not significantly modified melatonin concentrations between 3 and 12 months of age.
Conclusion
Patients with high IOP present increased concentrations of melatonin in their aqueous humour compared to normotensive patients. This has been confirmed in a glaucomatous animal model in which it has been possible to see a correlation between the development of the pathology, with an increase in IOP, and a concomitant elevation of melatonin in the aqueous humour.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Aqueous Humor - metabolism</subject><subject>aqueous humour</subject><subject>Biomarkers - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>glaucoma</subject><subject>Glaucoma - metabolism</subject><subject>Glaucoma - physiopathology</subject><subject>high‐performance liquid chromatography</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>melatonin</subject><subject>Melatonin - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Middle Aged</subject><subject>Ocular Hypertension - metabolism</subject><subject>Ocular Hypertension - physiopathology</subject><subject>Ophthalmology</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctKAzEUhoMotlYXvoAMuNHF2MlkcluWUi9Q7EIFdyFJT-mUudRkRunbm3ZqF4JgNgnnfPk4hx-hS5zc4XCGuvZ3mKSUHKE-5pTGhDNxfHjT9x46836VJAwzlp2iXsqppFxkffQ8KeBTNzCP8qpxurZtoV20duB96yAUrQPtwUclFLqpq7yKwgcofGhFzRIi_dFC3fpo2ZZ1687RyUIXHi729wC93U9ex4_xdPbwNB5NY5ulmMQcc2MlIZLTBTXCGIsNk1IboQkTxjKhE2MklxbPU2DYJHObcAKWYY4ztiADdNN5164OA_hGlbm3UBS62k6jsJBYCMaI-AdKJSeCZSyg17_QVdipCouonS0JPhqo246yrvbewUKtXV5qt1E4Uds8VMhD7fII7NXe2JoS5gfyJ4AADDvgKy9g87dJjWYvnfIbhamUKA</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Alkozi, Hanan</creator><creator>Sánchez‐Naves, Juan</creator><creator>Lara, Maria Jesús Perez</creator><creator>Carracedo, Gonzalo</creator><creator>Fonseca, Begoña</creator><creator>Martinez‐Aguila, Alejandro</creator><creator>Pintor, Jesús</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Elevated intraocular pressure increases melatonin levels in the aqueous humour</title><author>Alkozi, Hanan ; Sánchez‐Naves, Juan ; Lara, Maria Jesús Perez ; Carracedo, Gonzalo ; Fonseca, Begoña ; Martinez‐Aguila, Alejandro ; Pintor, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4213-717bc933975f5b8bbc1b699ab8a368bc68a0bb979c1d2e61b0dc073ec617146f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Aqueous Humor - metabolism</topic><topic>aqueous humour</topic><topic>Biomarkers - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>glaucoma</topic><topic>Glaucoma - metabolism</topic><topic>Glaucoma - physiopathology</topic><topic>high‐performance liquid chromatography</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>melatonin</topic><topic>Melatonin - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Middle Aged</topic><topic>Ocular Hypertension - metabolism</topic><topic>Ocular Hypertension - physiopathology</topic><topic>Ophthalmology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alkozi, Hanan</creatorcontrib><creatorcontrib>Sánchez‐Naves, Juan</creatorcontrib><creatorcontrib>Lara, Maria Jesús Perez</creatorcontrib><creatorcontrib>Carracedo, Gonzalo</creatorcontrib><creatorcontrib>Fonseca, Begoña</creatorcontrib><creatorcontrib>Martinez‐Aguila, Alejandro</creatorcontrib><creatorcontrib>Pintor, Jesús</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alkozi, Hanan</au><au>Sánchez‐Naves, Juan</au><au>Lara, Maria Jesús Perez</au><au>Carracedo, Gonzalo</au><au>Fonseca, Begoña</au><au>Martinez‐Aguila, Alejandro</au><au>Pintor, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated intraocular pressure increases melatonin levels in the aqueous humour</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2017-05</date><risdate>2017</risdate><volume>95</volume><issue>3</issue><spage>e185</spage><epage>e189</epage><pages>e185-e189</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma.
Methods
A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided into normotensive patients, with IOP below 21 mmHg (n = 23), and hypertensive patients, with IOP > 21 mmHg (n = 14). Glaucomatous DBA/2J (n = 6) and control C57BL/6J (n = 6) mice presenting 3 and 12 months of age for each strain were also used. Human and mice aqueous humours were aspirated using a 30‐gauge Rycroft cannula on a tuberculin syringe and further processed to quantify melatonin by high‐performance liquid chromatography analysis.
Results
Melatonin levels in normotensive patients (IOP below 21 mmHg) presented values as medians (first quartile; third quartile) of 14.62 (5.38;37.99) ng/ml (n = 23), while hypertensive patients (IOP above 21 mmHg) showed melatonin concentrations of 46.63 (10.28; 167.28) ng/ml (n = 14; p < 0.039). Glaucoma mice presented melatonin values of 0.37 (0.34; 0.59) ng/ml (at 3 months of age, before the pathology starts), which increased to 1.55 (0.94; 1.88) ng/ml (at 12 months of age, when the pathology is fully developed and IOP is maximum; n = 6, p < 0.001). Control mice did not significantly modified melatonin concentrations between 3 and 12 months of age.
Conclusion
Patients with high IOP present increased concentrations of melatonin in their aqueous humour compared to normotensive patients. This has been confirmed in a glaucomatous animal model in which it has been possible to see a correlation between the development of the pathology, with an increase in IOP, and a concomitant elevation of melatonin in the aqueous humour.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27595784</pmid><doi>10.1111/aos.13253</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta ophthalmologica (Oxford, England), 2017-05, Vol.95 (3), p.e185-e189 |
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| subjects | Adult Aged Aged, 80 and over Animals Aqueous Humor - metabolism aqueous humour Biomarkers - metabolism Chromatography, High Pressure Liquid Disease Models, Animal Female glaucoma Glaucoma - metabolism Glaucoma - physiopathology high‐performance liquid chromatography Humans Intraocular Pressure - physiology Male melatonin Melatonin - metabolism Mice Mice, Inbred C57BL Mice, Inbred DBA Middle Aged Ocular Hypertension - metabolism Ocular Hypertension - physiopathology Ophthalmology |
| title | Elevated intraocular pressure increases melatonin levels in the aqueous humour |
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