Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds
In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing mutations PB2-E627K and HA-G218...
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| Veröffentlicht in: | Archives of virology 2017-05, Vol.162 (5), p.1349-1353 |
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| container_title | Archives of virology |
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| creator | Jia, Yane Yang, Jiayun Wang, Zhengxiang Du, Yingying Cui, Jie Wang, Liang Guo, Fengfeng Yang, Maijuan Han, Shufang Zhu, Qiyun |
| description | In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing mutations PB2-E627K and HA-G218E were generated. These viruses caused dramatic body weight loss and death, and also replicated in mouse brain, suggesting that the pathogenicity of low pathogenic H10N5 in chickens can be enhanced after passage in mammals. Our data imply that H10N5 viruses might be a potential risk to human health therefore it is important to undertake continued surveillance and biosecurity evaluation of these viruses. |
| doi_str_mv | 10.1007/s00705-017-3234-3 |
| format | Article |
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This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing mutations PB2-E627K and HA-G218E were generated. These viruses caused dramatic body weight loss and death, and also replicated in mouse brain, suggesting that the pathogenicity of low pathogenic H10N5 in chickens can be enhanced after passage in mammals. Our data imply that H10N5 viruses might be a potential risk to human health therefore it is important to undertake continued surveillance and biosecurity evaluation of these viruses.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-017-3234-3</identifier><identifier>PMID: 28116526</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adaptation ; Animals ; Animals, Wild - virology ; Biomedical and Life Sciences ; Biomedicine ; Bird Diseases - virology ; Bird migration ; Birds - virology ; Brief Report ; Chick Embryo ; Female ; Genetic Markers - genetics ; Genomes ; Hemagglutinins, Viral - genetics ; Infections ; Infectious Diseases ; Influenza in Birds - virology ; Lungs ; Medical Microbiology ; Mice ; Mice, Inbred BALB C ; Mutation ; Orthomyxoviridae ; Phylogenetics ; Poultry ; Reassortant Viruses - classification ; Reassortant Viruses - genetics ; Reassortant Viruses - isolation & purification ; Virology ; Viruses</subject><ispartof>Archives of virology, 2017-05, Vol.162 (5), p.1349-1353</ispartof><rights>Springer-Verlag Wien 2017</rights><rights>Archives of Virology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-9732853eaca43853ef50b70407d3c53f887b7f98224a928bba544486218e17c33</citedby><cites>FETCH-LOGICAL-c405t-9732853eaca43853ef50b70407d3c53f887b7f98224a928bba544486218e17c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-017-3234-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-017-3234-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28116526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Yane</creatorcontrib><creatorcontrib>Yang, Jiayun</creatorcontrib><creatorcontrib>Wang, Zhengxiang</creatorcontrib><creatorcontrib>Du, Yingying</creatorcontrib><creatorcontrib>Cui, Jie</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Guo, Fengfeng</creatorcontrib><creatorcontrib>Yang, Maijuan</creatorcontrib><creatorcontrib>Han, Shufang</creatorcontrib><creatorcontrib>Zhu, Qiyun</creatorcontrib><title>Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing mutations PB2-E627K and HA-G218E were generated. These viruses caused dramatic body weight loss and death, and also replicated in mouse brain, suggesting that the pathogenicity of low pathogenic H10N5 in chickens can be enhanced after passage in mammals. Our data imply that H10N5 viruses might be a potential risk to human health therefore it is important to undertake continued surveillance and biosecurity evaluation of these viruses.</description><subject>Adaptation</subject><subject>Animals</subject><subject>Animals, Wild - virology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bird Diseases - virology</subject><subject>Bird migration</subject><subject>Birds - virology</subject><subject>Brief Report</subject><subject>Chick Embryo</subject><subject>Female</subject><subject>Genetic Markers - genetics</subject><subject>Genomes</subject><subject>Hemagglutinins, Viral - genetics</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Influenza in Birds - virology</subject><subject>Lungs</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mutation</subject><subject>Orthomyxoviridae</subject><subject>Phylogenetics</subject><subject>Poultry</subject><subject>Reassortant Viruses - classification</subject><subject>Reassortant Viruses - genetics</subject><subject>Reassortant Viruses - isolation & purification</subject><subject>Virology</subject><subject>Viruses</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1rFTEUhoMo9lr9AW4k4MbN1JOvyZmlFG2FYjftOmRmztSUuck1manUX99cbhUpCG6ScPLkPTk8jL0VcCIA7MdSFzANCNsoqXSjnrGN0Eo2aDt8zjagQDfYAh6xV6XcAtSCMi_ZkUQhWiPbDfNnFGkJA9_ltKO8BCrcx5Hv_PI93VAMQ1jueZq45zHd0cwz-VJSXnxc-LmAb4aHOM0rxV-e34W8Fj7ltOU_wzzyPuSxvGYvJj8XevO4H7PrL5-vTs-bi8uzr6efLppBg1maziqJRpEfvFb7w2Sgt6DBjmowakK0vZ06lFL7TmLfe6O1xlYKJGEHpY7Zh0NuneTHSmVx21AGmmcfKa3FCewEosEO_wNtRQumVaKi75-gt2nNsQ5SqdodsLO2UuJADTmVkmlyuxy2Pt87AW6vyh1UuarK7VW5_X_fPSav_ZbGPy9-u6mAPAClXsUbyn-1_mfqAz6hnGQ</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Jia, Yane</creator><creator>Yang, Jiayun</creator><creator>Wang, Zhengxiang</creator><creator>Du, Yingying</creator><creator>Cui, Jie</creator><creator>Wang, Liang</creator><creator>Guo, Fengfeng</creator><creator>Yang, Maijuan</creator><creator>Han, Shufang</creator><creator>Zhu, Qiyun</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds</title><author>Jia, Yane ; Yang, Jiayun ; Wang, Zhengxiang ; Du, Yingying ; Cui, Jie ; Wang, Liang ; Guo, Fengfeng ; Yang, Maijuan ; Han, Shufang ; Zhu, Qiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-9732853eaca43853ef50b70407d3c53f887b7f98224a928bba544486218e17c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptation</topic><topic>Animals</topic><topic>Animals, Wild - virology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bird Diseases - virology</topic><topic>Bird migration</topic><topic>Birds - virology</topic><topic>Brief Report</topic><topic>Chick Embryo</topic><topic>Female</topic><topic>Genetic Markers - genetics</topic><topic>Genomes</topic><topic>Hemagglutinins, Viral - genetics</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Influenza in Birds - virology</topic><topic>Lungs</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mutation</topic><topic>Orthomyxoviridae</topic><topic>Phylogenetics</topic><topic>Poultry</topic><topic>Reassortant Viruses - classification</topic><topic>Reassortant Viruses - genetics</topic><topic>Reassortant Viruses - isolation & purification</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Yane</creatorcontrib><creatorcontrib>Yang, Jiayun</creatorcontrib><creatorcontrib>Wang, Zhengxiang</creatorcontrib><creatorcontrib>Du, Yingying</creatorcontrib><creatorcontrib>Cui, Jie</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Guo, Fengfeng</creatorcontrib><creatorcontrib>Yang, Maijuan</creatorcontrib><creatorcontrib>Han, Shufang</creatorcontrib><creatorcontrib>Zhu, Qiyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Yane</au><au>Yang, Jiayun</au><au>Wang, Zhengxiang</au><au>Du, Yingying</au><au>Cui, Jie</au><au>Wang, Liang</au><au>Guo, Fengfeng</au><au>Yang, Maijuan</au><au>Han, Shufang</au><au>Zhu, Qiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>162</volume><issue>5</issue><spage>1349</spage><epage>1353</epage><pages>1349-1353</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing mutations PB2-E627K and HA-G218E were generated. These viruses caused dramatic body weight loss and death, and also replicated in mouse brain, suggesting that the pathogenicity of low pathogenic H10N5 in chickens can be enhanced after passage in mammals. Our data imply that H10N5 viruses might be a potential risk to human health therefore it is important to undertake continued surveillance and biosecurity evaluation of these viruses.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>28116526</pmid><doi>10.1007/s00705-017-3234-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archives of virology, 2017-05, Vol.162 (5), p.1349-1353 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adaptation Animals Animals, Wild - virology Biomedical and Life Sciences Biomedicine Bird Diseases - virology Bird migration Birds - virology Brief Report Chick Embryo Female Genetic Markers - genetics Genomes Hemagglutinins, Viral - genetics Infections Infectious Diseases Influenza in Birds - virology Lungs Medical Microbiology Mice Mice, Inbred BALB C Mutation Orthomyxoviridae Phylogenetics Poultry Reassortant Viruses - classification Reassortant Viruses - genetics Reassortant Viruses - isolation & purification Virology Viruses |
| title | Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds |
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