Long-Term Exposure of Pancreatic [beta]-Cells to Palmitate Results in SREBP-1C-Dependent Decreases in GLP-1 Receptor Signaling via CREB and AKT and Insulin Secretory Response

The effects of prolonged exposure of pancreatic [beta]-cells to high saturated fatty acids on glucagon-like peptide-1 (GLP-1) action were investigated. Murine islets, human pancreatic 1.1B4 cells, and rat INS-1E cells were exposed to palmitate for 24 hours. mRNA and protein expression/phosphorylatio...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2016-06, Vol.157 (6), p.2243-2258
Hauptverfasser:	Natalicchio, Annalisa, Biondi, Giuseppina, Marrano, Nicola, Labarbuta, Rossella, Tortosa, Federica, Spagnuolo, Rosaria, D'Oria, Rossella, Carchia, Emanuele, Leonardini, Anna, Cignarelli, Angelo, Perrini, Sebastio, Laviola, Luigi, Giorgino, Francesco
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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