Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics

Deregulation of mitotic microtubule (MT) dynamics results in defective spindle assembly and chromosome missegregation, leading further to chromosome instability, a hallmark of tumor cells. RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notc...

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Veröffentlicht in:	Oncogene 2017-04, Vol.36 (15), p.2146-2159
Hauptverfasser:	Steinhäuser, K, Klöble, P, Kreis, N-N, Ritter, A, Friemel, A, Roth, S, Reichel, J M, Michaelis, J, Rieger, M A, Louwen, F, Oswald, F, Yuan, J
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/44 14/19 14/35 14/63 42/109 42/89 631/80/103 631/80/641/1655 Acetylation Animals Apoptosis Cancer Cancer cells Carcinogenesis Cell Biology Cellular signal transduction Chromosomes Deregulation Development and progression DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - deficiency DNA-Binding Proteins - metabolism Embryo fibroblasts Genetic aspects HCT116 Cells Health aspects HeLa Cells Hepatocellular carcinoma Hepatoma Histone deacetylase Histone Deacetylase 6 Histone Deacetylases - metabolism Human Genetics Humans Internal Medicine Liver cancer MCF-7 Cells Medicine Medicine & Public Health Mice Mice, Knockout Microtubules Microtubules - metabolism Mitosis Mitosis - physiology Molecular modelling Neoplasm Proteins - biosynthesis Neoplasm Proteins - deficiency Neoplasm Proteins - metabolism Oncology original-article Phenotypes Physiological aspects Properties Protein expression Signal transduction Spindle Apparatus - metabolism Tubulin Tubulin - metabolism Tumor cell lines Tumor cells Tumor proteins Tumorigenesis
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