Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity

Leptin signaling in the central nervous system, and particularly the arcuate hypothalamic nucleus, is important for regulating energy and glucose homeostasis. However, the roles of extra-arcuate leptin responsive neurons are less defined. In the current study, we generated mice with widespread inact...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2016-07, Vol.157 (7), p.2671-2685
Hauptverfasser:	Denroche, Heather C, Glavas, Maria M, Tudurí, Eva, Karunakaran, Subashini, Quong, Whitney L, Philippe, Marion, Britton, Heidi M, Clee, Susanne M, Kieffer, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arcuate Nucleus of Hypothalamus - metabolism Blood Blood glucose Blood Glucose - metabolism Blood levels Body weight Body weight gain Central nervous system Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diet Diet, High-Fat Energy balance Flox Glucagon Glucagon - metabolism Glucose Glucose tolerance High fat diet Homeostasis Hyperinsulinemia Hypoglycemia Hypothalamic Area, Lateral - metabolism Hypothalamus Hypothalamus (lateral) Hypothalamus (ventromedial) Hypothalamus - metabolism Inactivation Insulin Insulin - metabolism Insulin Secretion Leptin - metabolism Mice Mice, Knockout Nervous system Neurogenesis Neurons Neurons - metabolism Obesity Obesity - metabolism Receptors, Leptin - genetics Receptors, Leptin - metabolism Secretion Signal Transduction - physiology Streptozocin Synapsin Ventromedial Hypothalamic Nucleus - metabolism
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