Induction of Amnion Epithelial Apoptosis by Cortisol via tPA/Plasmin System

Rupture of fetal membranes (ROM) can initiate parturition at both term and preterm birth. Apoptosis of the amnion epithelium plays a key role in structural remodeling of the membranes preceding ROM. However, the causative factors for apoptosis remain unidentified. Toward the end of gestation, a feed...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2016-11, Vol.157 (11), p.4487-4498
Hauptverfasser:	Wang, Wangsheng, Liu, Chao, Sun, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism 11β-Hydroxysteroid dehydrogenase Abundance Amnion Amnion - cytology Amnion - metabolism Apoptosis Apoptosis - genetics Apoptosis - physiology Bioaccumulation Blotting, Western Caspase 3 - metabolism Caspase-3 Cells, Cultured Chromatin Immunoprecipitation Cortisol Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelium Explants Extraembryonic Membranes - metabolism Female Fetal alcohol syndrome Fetuses Fibrinolysin - genetics Fibrinolysin - metabolism Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gestation Glucocorticoid receptors Glucocorticoids Hormones Humans Hydrocortisone - metabolism Hydroxysteroids In Situ Nick-End Labeling In Vitro Techniques Membranes Parturition Plasmin Pregnancy Premature birth Promoter Regions, Genetic - genetics Protein Binding RNA, Small Interfering t-Plasminogen activator Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism
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