The Epidemic History of HIV-1 CRF07_BC in Hetian Prefecture and the Role of It on HIV Spreading in China

CRF07_BC is one of the most prevalent HIV-1 strains in China, and Xinjiang Uygur Autonomous Region has ever been considered to be a second epidemic center after Yunnan Province in previous studies. Here we use HIV-1 pol gene sequences identified from Hetian Prefecture located in Xinjiang Autonomous...

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Veröffentlicht in:AIDS research and human retroviruses 2017-04, Vol.33 (4), p.364-367
Hauptverfasser: Wu, Jianjun, Guo, Hongxiong, Zhang, Jing, Liu, Xiaoming, Ayoupu, Aideaierli, Shen, Yuelan, Miao, Lifeng, Tang, Jihai, Lei, Yanhua, Su, Bin
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container_end_page 367
container_issue 4
container_start_page 364
container_title AIDS research and human retroviruses
container_volume 33
creator Wu, Jianjun
Guo, Hongxiong
Zhang, Jing
Liu, Xiaoming
Ayoupu, Aideaierli
Shen, Yuelan
Miao, Lifeng
Tang, Jihai
Lei, Yanhua
Su, Bin
description CRF07_BC is one of the most prevalent HIV-1 strains in China, and Xinjiang Uygur Autonomous Region has ever been considered to be a second epidemic center after Yunnan Province in previous studies. Here we use HIV-1 pol gene sequences identified from Hetian Prefecture located in Xinjiang Autonomous Region to reconstruct the epidemic history of HIV CRF07_BC strain circulating in this region. We found that CRF07_BC is the predominant HIV-1 form in Hetian Prefecture, and the estimated tMRCA analysis shows that there is no enough evidence supporting Xinjiang Autonomous Region as a second epidemic center of spreading HIV-1. It may imply that every city may be only a point among the HIV spreading network because of the frequent migration of population in the whole country nowadays.
doi_str_mv 10.1089/AID.2016.0214
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source MEDLINE; Alma/SFX Local Collection
subjects Adult
AIDS/HIV
China - epidemiology
Disease Transmission, Infectious
Epidemics
Female
Gene sequencing
Genotype
HIV Infections - epidemiology
HIV Infections - transmission
HIV-1 - classification
HIV-1 - genetics
HIV-1 - isolation & purification
Humans
Lentivirus
Male
Middle Aged
Migration
Molecular Epidemiology
Pol gene
pol Gene Products, Human Immunodeficiency Virus
Prevalence
Retroviridae
Sequence Analysis, DNA
Spreading
Young Adult
title The Epidemic History of HIV-1 CRF07_BC in Hetian Prefecture and the Role of It on HIV Spreading in China
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