DissolvIt: An In Vitro Method for Simulating the Dissolution and Absorption of Inhaled Dry Powder Drugs in the Lungs

The main purpose of this work was to develop an in vitro method for simulating the dissolution and absorption of inhaled dry powder drugs that also mimics systemic pharmacokinetic data. A second purpose was to evaluate this method. DissolvIt was developed as a simulation of the air-blood barrier of...

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Veröffentlicht in:	Assay and drug development technologies 2017-02, Vol.15 (2), p.77-88
Hauptverfasser:	Gerde, Per, Malmlöf, Maria, Havsborn, Lina, Sjöberg, Carl-Olof, Ewing, Pär, Eirefelt, Stefan, Ekelund, Katarina
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Absorption, Physicochemical Administration, Inhalation Aerosols Albumin Biomimetic Materials - pharmacokinetics Blood flow Budesonide Buffers Diffusion barriers Dissolution Drugs Equipment Design Fluticasone Formulations In vitro methods and tests Liquid chromatography Lung - chemistry Lungs Mass spectrometry Mass spectroscopy Microfluidics - instrumentation Microscopy Mucus Mucus - chemistry Optical microscopy Pharmacology Polycarbonate Powder Powders - administration & dosage Powders - chemistry Propionic acid Respiratory Tract Absorption Simulation Solubility
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