A Dietary Medium-Chain Fatty Acid, Decanoic Acid, Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome

Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%–70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resi...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2016-01, Vol.157 (1), p.382-394
Hauptverfasser:	Lee, Bao Hui, Indran, Inthrani Raja, Tan, Huey Min, Li, Yu, Zhang, Zhiwei, Li, Jun, Yong, Eu-Leong
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acid resistance Adrenal Cortex - enzymology Adrenal Cortex - metabolism Adrenal Cortex - secretion Adrenal Glands - enzymology Adrenal Glands - metabolism Adrenal Glands - secretion Androgens Androgens - analysis Androgens - chemistry Androgens - secretion Animals Biosynthesis Cell Line Cyclic AMP Cyclic AMP - antagonists & inhibitors Cyclic AMP - metabolism Decanoic Acids - metabolism Decanoic Acids - therapeutic use Diabetes mellitus Dietary Fats - metabolism Dietary Fats - therapeutic use Disease Models, Animal Enzyme Repression Estrus cycle Fatty acids Female Fertility Glucose tolerance Humans Hydroxysteroids Hyperandrogenism - etiology Hyperandrogenism - prevention & control Hyperinsulinemia Insulin Insulin Resistance Lipids Metabolism Metformin Nuclear Receptor Subfamily 4, Group A, Member 1 - antagonists & inhibitors Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Nur77 protein Ovaries Ovary - enzymology Ovary - metabolism Ovary - secretion Polycystic ovary syndrome Polycystic Ovary Syndrome - diet therapy Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - pathology Polycystic Ovary Syndrome - physiopathology Progesterone Reductase - antagonists & inhibitors Progesterone Reductase - genetics Progesterone Reductase - metabolism Promoter Regions, Genetic Protein biosynthesis Protein expression Proteins Random Allocation Rats, Wistar Testosterone
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