A Positive Feedback Loop of lncRNA- PVT1 and FOXM1 Facilitates Gastric Cancer Growth and Invasion

The long, noncoding RNA (lncRNA) is an important epigenetic regulator with a critical role in human tumors. Here, we aimed to investigate the clinical application and the potential molecular mechanisms of in gastric cancer tumorigenesis and progression. The expression level of was determined by RT-q...

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Veröffentlicht in:	Clinical cancer research 2017-04, Vol.23 (8), p.2071-2080
Hauptverfasser:	Xu, Mi-Die, Wang, Yiqin, Weng, Weiwei, Wei, Ping, Qi, Peng, Zhang, Qiongyan, Tan, Cong, Ni, Shu-Juan, Dong, Lei, Yang, Yusi, Lin, Wanrun, Xu, Qinghua, Huang, Dan, Huang, Zhaohui, Ma, Yuqing, Zhang, Wei, Sheng, Weiqi, Du, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Blotting, Western Cancer Cell Proliferation Chromatin Chromatin Immunoprecipitation Disease-Free Survival Experimental design Feedback Feedback loops Feedback, Physiological Forkhead Box Protein M1 - biosynthesis Forkhead Box Protein M1 - genetics Gastric cancer Gastric mucosa Gene Expression Regulation, Neoplastic - genetics Humans Immunoprecipitation Kaplan-Meier Estimate Mass Spectrometry Mass spectroscopy Molecular modelling Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Pharmacology Positive feedback Proportional Hazards Models Proteins Ribonucleic acid RNA RNA, Long Noncoding - genetics Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - pathology Tissues Transcription Tumorigenesis Tumors Up-Regulation
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