Improved production of quinone-methide triterpenoids by Cheiloclinium cognatum root cultures: possibilities for a non-destructive biotechnological process
Quinone-methide triterpenoids (QMTs) derived from species of the family Celastraceae have long been used as anti-cancer, anti-inflammatory, anti-oxidant, anti-malarial and insecticidal agents. The main problem in producing QMTs on a large-scale from natural sources is the low amounts (
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| Veröffentlicht in: | Plant cell, tissue and organ culture tissue and organ culture, 2017-03, Vol.128 (3), p.705-714 |
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| creator | Pina, Edieidia S. Coppede, Juliana S. Contini, Silvia H. Taleb Crevelin, Eduardo J. Lião, Luciano M. Bertoni, Bianca W. França, Suzelei C. Pereira, Ana Maria S. |
| description | Quinone-methide triterpenoids (QMTs) derived from species of the family Celastraceae have long been used as anti-cancer, anti-inflammatory, anti-oxidant, anti-malarial and insecticidal agents. The main problem in producing QMTs on a large-scale from natural sources is the low amounts ( |
| doi_str_mv | 10.1007/s11240-016-1151-x |
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Cheiloclinium cognatum
cultured in vitro with those of in vivo plants aged 6 months to 10 years. The highest levels of QMTs produced by in vivo specimens were found in root bark of 10-year old plants, but in vitro cultured roots produced 3.52-times more 22β-hydroxy-maytenin and 11.46-times more maytenin. Most importantly, the cultured roots excreted QMTs into the growth medium, thereby facilitating the large-scale production, extraction and purification of these bioactive compounds by means of a continuous and non-destructive bioprocess that would preserve the root cultures.</description><identifier>ISSN: 0167-6857</identifier><identifier>EISSN: 1573-5044</identifier><identifier>DOI: 10.1007/s11240-016-1151-x</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Bark ; Bioactive compounds ; Biocompatibility ; Biomedical and Life Sciences ; Biotechnology ; Cancer ; Celastraceae ; In vitro methods and tests ; In vivo methods and tests ; Inflammation ; Life Sciences ; Original Article ; Oxidizing agents ; Plant Genetics and Genomics ; Plant Pathology ; Plant Physiology ; Plant Sciences ; Plants (botany) ; Purification ; Quinones ; Roots ; Triterpenoids</subject><ispartof>Plant cell, tissue and organ culture, 2017-03, Vol.128 (3), p.705-714</ispartof><rights>Springer Science+Business Media Dordrecht 2016</rights><rights>Copyright Springer Science & Business Media 2017</rights><rights>Plant Cell, Tissue and Organ Culture (PCTOC) is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-8d64916cb92e421c048a498b50e4244ea5f7dafa1e50951ebe32c3a822d849413</citedby><cites>FETCH-LOGICAL-c377t-8d64916cb92e421c048a498b50e4244ea5f7dafa1e50951ebe32c3a822d849413</cites><orcidid>0000-0002-3478-4718</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11240-016-1151-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11240-016-1151-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Pina, Edieidia S.</creatorcontrib><creatorcontrib>Coppede, Juliana S.</creatorcontrib><creatorcontrib>Contini, Silvia H. Taleb</creatorcontrib><creatorcontrib>Crevelin, Eduardo J.</creatorcontrib><creatorcontrib>Lião, Luciano M.</creatorcontrib><creatorcontrib>Bertoni, Bianca W.</creatorcontrib><creatorcontrib>França, Suzelei C.</creatorcontrib><creatorcontrib>Pereira, Ana Maria S.</creatorcontrib><title>Improved production of quinone-methide triterpenoids by Cheiloclinium cognatum root cultures: possibilities for a non-destructive biotechnological process</title><title>Plant cell, tissue and organ culture</title><addtitle>Plant Cell Tiss Organ Cult</addtitle><description>Quinone-methide triterpenoids (QMTs) derived from species of the family Celastraceae have long been used as anti-cancer, anti-inflammatory, anti-oxidant, anti-malarial and insecticidal agents. The main problem in producing QMTs on a large-scale from natural sources is the low amounts (<0.4% dry weight) produced by plants grown in vivo. The aim of this study was to compare the levels of QMTs accumulated by roots of
Cheiloclinium cognatum
cultured in vitro with those of in vivo plants aged 6 months to 10 years. The highest levels of QMTs produced by in vivo specimens were found in root bark of 10-year old plants, but in vitro cultured roots produced 3.52-times more 22β-hydroxy-maytenin and 11.46-times more maytenin. Most importantly, the cultured roots excreted QMTs into the growth medium, thereby facilitating the large-scale production, extraction and purification of these bioactive compounds by means of a continuous and non-destructive bioprocess that would preserve the root cultures.</description><subject>Bark</subject><subject>Bioactive compounds</subject><subject>Biocompatibility</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Celastraceae</subject><subject>In vitro methods and tests</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Original Article</subject><subject>Oxidizing agents</subject><subject>Plant Genetics and Genomics</subject><subject>Plant Pathology</subject><subject>Plant Physiology</subject><subject>Plant Sciences</subject><subject>Plants (botany)</subject><subject>Purification</subject><subject>Quinones</subject><subject>Roots</subject><subject>Triterpenoids</subject><issn>0167-6857</issn><issn>1573-5044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9Uc2KFDEQbkTBcfUBvAW8eImm0kkn8SaDPwsLXvQc0unqmSw9yWySXnZfxac1zXgQQU9VRb4_8nXda2DvgDH1vgBwwSiDgQJIoA9Puh1I1VPJhHja7dqDooOW6nn3opRbxtjQC9h1P69P55zucSJtTKuvIUWSZnK3hpgi0hPWY5iQ1Bwq5jPGFKZCxkeyP2JYkl9CDOuJ-HSIrrYlp1SJX5e6ZiwfyDmVEsawhBqwkDll4kjTpROWmje3eyRjSBX9MaYlHYJ3y5bEYykvu2ezWwq--j2vuh-fP33ff6U3375c7z_eUN8rVameBmFg8KPhKDh4JrQTRo-StVMIdHJWk5sdoGRGAo7Yc987zfmkhRHQX3VvL7rN925twewpFI_L4iKmtVjQBrSSfW8a9M1f0Nu05tjSWc6l6Y2RXPwPBVozpTjwzRYuKJ_bJ2Wc7TmHk8uPFpjdOrWXTm2rzm6d2ofG4RdOadh4wPyH8j9JvwDV7qgQ</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Pina, Edieidia S.</creator><creator>Coppede, Juliana S.</creator><creator>Contini, Silvia H. Taleb</creator><creator>Crevelin, Eduardo J.</creator><creator>Lião, Luciano M.</creator><creator>Bertoni, Bianca W.</creator><creator>França, Suzelei C.</creator><creator>Pereira, Ana Maria S.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-3478-4718</orcidid></search><sort><creationdate>20170301</creationdate><title>Improved production of quinone-methide triterpenoids by Cheiloclinium cognatum root cultures: possibilities for a non-destructive biotechnological process</title><author>Pina, Edieidia S. ; Coppede, Juliana S. ; Contini, Silvia H. Taleb ; Crevelin, Eduardo J. ; Lião, Luciano M. ; Bertoni, Bianca W. ; França, Suzelei C. ; Pereira, Ana Maria S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-8d64916cb92e421c048a498b50e4244ea5f7dafa1e50951ebe32c3a822d849413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bark</topic><topic>Bioactive compounds</topic><topic>Biocompatibility</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Celastraceae</topic><topic>In vitro methods and tests</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Life Sciences</topic><topic>Original Article</topic><topic>Oxidizing agents</topic><topic>Plant Genetics and Genomics</topic><topic>Plant Pathology</topic><topic>Plant Physiology</topic><topic>Plant Sciences</topic><topic>Plants (botany)</topic><topic>Purification</topic><topic>Quinones</topic><topic>Roots</topic><topic>Triterpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pina, Edieidia S.</creatorcontrib><creatorcontrib>Coppede, Juliana S.</creatorcontrib><creatorcontrib>Contini, Silvia H. Taleb</creatorcontrib><creatorcontrib>Crevelin, Eduardo J.</creatorcontrib><creatorcontrib>Lião, Luciano M.</creatorcontrib><creatorcontrib>Bertoni, Bianca W.</creatorcontrib><creatorcontrib>França, Suzelei C.</creatorcontrib><creatorcontrib>Pereira, Ana Maria S.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Plant cell, tissue and organ culture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pina, Edieidia S.</au><au>Coppede, Juliana S.</au><au>Contini, Silvia H. Taleb</au><au>Crevelin, Eduardo J.</au><au>Lião, Luciano M.</au><au>Bertoni, Bianca W.</au><au>França, Suzelei C.</au><au>Pereira, Ana Maria S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved production of quinone-methide triterpenoids by Cheiloclinium cognatum root cultures: possibilities for a non-destructive biotechnological process</atitle><jtitle>Plant cell, tissue and organ culture</jtitle><stitle>Plant Cell Tiss Organ Cult</stitle><date>2017-03-01</date><risdate>2017</risdate><volume>128</volume><issue>3</issue><spage>705</spage><epage>714</epage><pages>705-714</pages><issn>0167-6857</issn><eissn>1573-5044</eissn><abstract>Quinone-methide triterpenoids (QMTs) derived from species of the family Celastraceae have long been used as anti-cancer, anti-inflammatory, anti-oxidant, anti-malarial and insecticidal agents. The main problem in producing QMTs on a large-scale from natural sources is the low amounts (<0.4% dry weight) produced by plants grown in vivo. The aim of this study was to compare the levels of QMTs accumulated by roots of
Cheiloclinium cognatum
cultured in vitro with those of in vivo plants aged 6 months to 10 years. The highest levels of QMTs produced by in vivo specimens were found in root bark of 10-year old plants, but in vitro cultured roots produced 3.52-times more 22β-hydroxy-maytenin and 11.46-times more maytenin. Most importantly, the cultured roots excreted QMTs into the growth medium, thereby facilitating the large-scale production, extraction and purification of these bioactive compounds by means of a continuous and non-destructive bioprocess that would preserve the root cultures.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s11240-016-1151-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3478-4718</orcidid></addata></record> |
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| ispartof | Plant cell, tissue and organ culture, 2017-03, Vol.128 (3), p.705-714 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Bark Bioactive compounds Biocompatibility Biomedical and Life Sciences Biotechnology Cancer Celastraceae In vitro methods and tests In vivo methods and tests Inflammation Life Sciences Original Article Oxidizing agents Plant Genetics and Genomics Plant Pathology Plant Physiology Plant Sciences Plants (botany) Purification Quinones Roots Triterpenoids |
| title | Improved production of quinone-methide triterpenoids by Cheiloclinium cognatum root cultures: possibilities for a non-destructive biotechnological process |
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