Synthesis of honokiol analogues and evaluation of their modulating action on VEGF protein secretion and telomerase‐related gene expressions

A group of 36 biphenyl derivatives structurally related to honokiol were synthesized by means of Suzuki coupling reactions. Their cytotoxicities were evaluated and compared to that of honokiol. Some of the compounds were then evaluated for their ability to downregulate the secretion of the VEGF prot...

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Veröffentlicht in:	Chemical biology & drug design 2017-04, Vol.89 (4), p.577-584
Hauptverfasser:	Sánchez‐Peris, María, Murga, Juan, Falomir, Eva, Carda, Miguel, Marco, Juan Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Biphenyl Compounds - chemistry Biphenyl Compounds - pharmacology c‐Myc Enzyme-Linked Immunosorbent Assay Gene Expression - drug effects gene regulation HEK293 Cells honokiol analogues HT29 Cells hTERT Humans Lignans - chemistry Lignans - pharmacology MCF-7 Cells telomerase Telomerase - genetics Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - secretion VEGF
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