A pan-coronary artery angiographic study of the association between diabetes mellitus and progression or regression of coronary atherosclerosis
The frequency and pattern of progression or regression of coronary atherosclerosis in contemporary patients with diabetes remain unknown. This study included 605 patients with coronary artery disease (CAD). Two coronary angiographic examinations at baseline and after 2 years were performed. The anal...
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| Veröffentlicht in: | Heart and vessels 2017-04, Vol.32 (4), p.376-384 |
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| description | The frequency and pattern of progression or regression of coronary atherosclerosis in contemporary patients with diabetes remain unknown. This study included 605 patients with coronary artery disease (CAD). Two coronary angiographic examinations at baseline and after 2 years were performed. The analysis focused on non-stented segments with diameter stenosis ≥25 %. Atherosclerosis progression (or regression) was defined as a decrease (or increase) in the mean minimal lumen diameter (MLD) in the 2-year angiogram compared to mean MLD in the baseline angiogram of >0.2 mm. Statins were prescribed in 576 patients (95.2 %). The primary outcome was atherosclerosis progression or regression in the 2-year angiogram. One hundred sixty-nine patients (28 %) had diabetes. Diabetic patients had greater reduction of mean MLD in the 24 angiogram compared to baseline angiogram than nondiabetic patients (0.11 ± 0.18 vs. −0.08 ± 0.15 mm,
P
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| doi_str_mv | 10.1007/s00380-016-0889-8 |
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P
< 0.001). Atherosclerosis progression was observed in 37 patients with diabetes and 16 nondiabetic patients (21.9 vs. 3.7 %;
P
< 0.001). Atherosclerosis regression was observed in two diabetic patients and 78 nondiabetic patients (1.2 vs. 17.9 %;
P
< 0.001). A progression pattern across all coronary segments was observed in 70 patients (41.4 %) with diabetes and 60 patients (13.8 %) without diabetes (
P
< 0.001). Diabetic patients with a low-density lipoprotein cholesterol ≥70 mg/dl showed more atherosclerosis progression than diabetic patients with LDL cholesterol <70 mg/dl (delta-MLD: 0.12 ± 0.19 vs. 0.08 ± 0.16 mm;
P
= 0.04). In conclusion, in contemporary patients with CAD treated with moderate-intensity statin therapy, diabetes is associated with the increased risk of progression and decreased probability of regression of coronary atherosclerosis.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-016-0889-8</identifier><identifier>PMID: 27557547</identifier><identifier>CODEN: HEVEEO</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Atherosclerosis ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - drug therapy ; Biomedical Engineering and Bioengineering ; C-Reactive Protein - analysis ; Cardiac Surgery ; Cardiology ; Cardiovascular disease ; Cholesterol, LDL - blood ; Coronary Angiography ; Coronary Artery Disease - complications ; Coronary Vessels - diagnostic imaging ; Databases, Factual ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Disease Progression ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Regression Analysis ; Statins ; Vascular Surgery</subject><ispartof>Heart and vessels, 2017-04, Vol.32 (4), p.376-384</ispartof><rights>Springer Japan 2016</rights><rights>Heart and Vessels is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-676949ad6f1ab9dd33e0e041b199e9d499eb82bd4b281370e907d41fb7a47f603</citedby><cites>FETCH-LOGICAL-c495t-676949ad6f1ab9dd33e0e041b199e9d499eb82bd4b281370e907d41fb7a47f603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-016-0889-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-016-0889-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27557547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iijima, Raisuke</creatorcontrib><creatorcontrib>Ndrepepa, Gjin</creatorcontrib><creatorcontrib>Kujath, Vivien</creatorcontrib><creatorcontrib>Harada, Yukinori</creatorcontrib><creatorcontrib>Kufner, Sebastian</creatorcontrib><creatorcontrib>Schunkert, Heribert</creatorcontrib><creatorcontrib>Nakamura, Masato</creatorcontrib><creatorcontrib>Kastrati, Adnan</creatorcontrib><title>A pan-coronary artery angiographic study of the association between diabetes mellitus and progression or regression of coronary atherosclerosis</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>The frequency and pattern of progression or regression of coronary atherosclerosis in contemporary patients with diabetes remain unknown. This study included 605 patients with coronary artery disease (CAD). Two coronary angiographic examinations at baseline and after 2 years were performed. The analysis focused on non-stented segments with diameter stenosis ≥25 %. Atherosclerosis progression (or regression) was defined as a decrease (or increase) in the mean minimal lumen diameter (MLD) in the 2-year angiogram compared to mean MLD in the baseline angiogram of >0.2 mm. Statins were prescribed in 576 patients (95.2 %). The primary outcome was atherosclerosis progression or regression in the 2-year angiogram. One hundred sixty-nine patients (28 %) had diabetes. Diabetic patients had greater reduction of mean MLD in the 24 angiogram compared to baseline angiogram than nondiabetic patients (0.11 ± 0.18 vs. −0.08 ± 0.15 mm,
P
< 0.001). Atherosclerosis progression was observed in 37 patients with diabetes and 16 nondiabetic patients (21.9 vs. 3.7 %;
P
< 0.001). Atherosclerosis regression was observed in two diabetic patients and 78 nondiabetic patients (1.2 vs. 17.9 %;
P
< 0.001). A progression pattern across all coronary segments was observed in 70 patients (41.4 %) with diabetes and 60 patients (13.8 %) without diabetes (
P
< 0.001). Diabetic patients with a low-density lipoprotein cholesterol ≥70 mg/dl showed more atherosclerosis progression than diabetic patients with LDL cholesterol <70 mg/dl (delta-MLD: 0.12 ± 0.19 vs. 0.08 ± 0.16 mm;
P
= 0.04). In conclusion, in contemporary patients with CAD treated with moderate-intensity statin therapy, diabetes is associated with the increased risk of progression and decreased probability of regression of coronary atherosclerosis.</description><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - drug therapy</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Databases, Factual</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Regression Analysis</subject><subject>Statins</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1v1DAQhi0EokvbH8AFWeLCxTBO7Ng-VhVfUqVe4Gw58WTrajde7ESov4K_zKRbKEJC4uKx5Wfe-XgZeynhrQQw7ypAa0GA7ARY64R9wjayk1o02rRP2QacBGHbxpywF7XeAkjtpHvOThqjtdHKbNiPC34IkxhyyVModzyUGdcwbVPelnC4SQOv8xLveB75fIM81JqHFOaUJ97j_B1x4jEFumLle9zt0rxUyo_8UEgBa13JXHjBx9fIHwuSaMl12K1nqmfs2Rh2Fc8f4in7-uH9l8tP4ur64-fLiysxKKdn0ZnOKRdiN8rQuxjbFgFByV46hy4qOnvb9FH1jZWtAXRgopJjb4IyYwftKXtz1KUuvy1YZ79PdaD2w4R5qV5aJ23nOmf-A9XO0NqdJvT1X-htXspEgxBlidDqXlAeqYFGrgVHfyhpT8vwEvxqrD8a68lYvxrrLeW8elBe-j3G3xm_nCSgOQKVvqYtlj9K_1P1J8ljsMM</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Iijima, Raisuke</creator><creator>Ndrepepa, Gjin</creator><creator>Kujath, Vivien</creator><creator>Harada, Yukinori</creator><creator>Kufner, Sebastian</creator><creator>Schunkert, Heribert</creator><creator>Nakamura, Masato</creator><creator>Kastrati, Adnan</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>A pan-coronary artery angiographic study of the association between diabetes mellitus and progression or regression of coronary atherosclerosis</title><author>Iijima, Raisuke ; Ndrepepa, Gjin ; Kujath, Vivien ; Harada, Yukinori ; Kufner, Sebastian ; Schunkert, Heribert ; Nakamura, Masato ; Kastrati, Adnan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-676949ad6f1ab9dd33e0e041b199e9d499eb82bd4b281370e907d41fb7a47f603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - drug therapy</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Databases, Factual</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Regression Analysis</topic><topic>Statins</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iijima, Raisuke</creatorcontrib><creatorcontrib>Ndrepepa, Gjin</creatorcontrib><creatorcontrib>Kujath, Vivien</creatorcontrib><creatorcontrib>Harada, Yukinori</creatorcontrib><creatorcontrib>Kufner, Sebastian</creatorcontrib><creatorcontrib>Schunkert, Heribert</creatorcontrib><creatorcontrib>Nakamura, Masato</creatorcontrib><creatorcontrib>Kastrati, Adnan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iijima, Raisuke</au><au>Ndrepepa, Gjin</au><au>Kujath, Vivien</au><au>Harada, Yukinori</au><au>Kufner, Sebastian</au><au>Schunkert, Heribert</au><au>Nakamura, Masato</au><au>Kastrati, Adnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pan-coronary artery angiographic study of the association between diabetes mellitus and progression or regression of coronary atherosclerosis</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>32</volume><issue>4</issue><spage>376</spage><epage>384</epage><pages>376-384</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><coden>HEVEEO</coden><abstract>The frequency and pattern of progression or regression of coronary atherosclerosis in contemporary patients with diabetes remain unknown. This study included 605 patients with coronary artery disease (CAD). Two coronary angiographic examinations at baseline and after 2 years were performed. The analysis focused on non-stented segments with diameter stenosis ≥25 %. Atherosclerosis progression (or regression) was defined as a decrease (or increase) in the mean minimal lumen diameter (MLD) in the 2-year angiogram compared to mean MLD in the baseline angiogram of >0.2 mm. Statins were prescribed in 576 patients (95.2 %). The primary outcome was atherosclerosis progression or regression in the 2-year angiogram. One hundred sixty-nine patients (28 %) had diabetes. Diabetic patients had greater reduction of mean MLD in the 24 angiogram compared to baseline angiogram than nondiabetic patients (0.11 ± 0.18 vs. −0.08 ± 0.15 mm,
P
< 0.001). Atherosclerosis progression was observed in 37 patients with diabetes and 16 nondiabetic patients (21.9 vs. 3.7 %;
P
< 0.001). Atherosclerosis regression was observed in two diabetic patients and 78 nondiabetic patients (1.2 vs. 17.9 %;
P
< 0.001). A progression pattern across all coronary segments was observed in 70 patients (41.4 %) with diabetes and 60 patients (13.8 %) without diabetes (
P
< 0.001). Diabetic patients with a low-density lipoprotein cholesterol ≥70 mg/dl showed more atherosclerosis progression than diabetic patients with LDL cholesterol <70 mg/dl (delta-MLD: 0.12 ± 0.19 vs. 0.08 ± 0.16 mm;
P
= 0.04). In conclusion, in contemporary patients with CAD treated with moderate-intensity statin therapy, diabetes is associated with the increased risk of progression and decreased probability of regression of coronary atherosclerosis.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27557547</pmid><doi>10.1007/s00380-016-0889-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Atherosclerosis Atherosclerosis - diagnostic imaging Atherosclerosis - drug therapy Biomedical Engineering and Bioengineering C-Reactive Protein - analysis Cardiac Surgery Cardiology Cardiovascular disease Cholesterol, LDL - blood Coronary Angiography Coronary Artery Disease - complications Coronary Vessels - diagnostic imaging Databases, Factual Diabetes Diabetes Mellitus, Type 2 - complications Disease Progression Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Medical imaging Medicine Medicine & Public Health Middle Aged Original Article Regression Analysis Statins Vascular Surgery |
| title | A pan-coronary artery angiographic study of the association between diabetes mellitus and progression or regression of coronary atherosclerosis |
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