Nuclear diacylglycerol lipase‐α in rat brain cortical neurons: evidence of 2‐arachidonoylglycerol production in concert with phospholipase C‐β activity

In this report, we describe the localization of diacylglycerol lipase‐α (DAGLα) in nuclei from adult cortical neurons, as assessed by double‐immunofluorescence staining of rat brain cortical sections and purified intact nuclei and by western blot analysis of subnuclear fractions. Double‐labeling ass...

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Veröffentlicht in:	Journal of neurochemistry 2015-03, Vol.132 (5), p.489-503
Hauptverfasser:	García del Caño, Gontzal, Aretxabala, Xabier, González‐Burguera, Imanol, Montaña, Mario, López de Jesús, Maider, Barrondo, Sergio, Barrio, Ramón J., Sampedro, Carmen, Goicolea, M. Arantzazu, Sallés, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	2‐AG production Animals Arachidonic Acids - biosynthesis Blotting, Western Cell Nucleus - metabolism Chromatography, Liquid DAGLα Endocannabinoids - biosynthesis Fluorescent Antibody Technique Glycerides - biosynthesis Lipoprotein Lipase - metabolism Male neuronal nuclei Neurons - metabolism Phospholipase C beta - metabolism PLCβ1 PLCβ2 PLCβ4 Rats Rats, Sprague-Dawley Somatosensory Cortex - metabolism Tandem Mass Spectrometry
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