Transient abnormal myelopoiesis in non‐Down syndrome neonate

We encountered a case of neonatal acute megakaryoblastic leukemia not associated with Down syndrome (DS). Molecular cytogenetic analysis of leukemic blast cells indicated that increased blast cell status was caused by transient abnormal myelopoiesis with trisomy 21 and GATA1 mutation. Based on these...

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Veröffentlicht in:	Pediatrics international 2015-02, Vol.57 (1), p.e14-e17
Hauptverfasser:	Ohkawa, Teppei, Miyamoto, Satoshi, Sugie, Manabu, Tomizawa, Daisuke, Imai, Kohsuke, Nagasawa, Masayuki, Morio, Tomohiro, Mizutani, Shuki, Takagi, Masatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	acute megakaryoblastic leukemia Blotting, Western Chemotherapy DNA - genetics Down syndrome Down Syndrome - genetics Down Syndrome - metabolism GATA1 GATA1 Transcription Factor - genetics GATA1 Transcription Factor - metabolism Humans Infant, Newborn Leukemia Leukemoid Reaction - genetics Leukemoid Reaction - metabolism Mutation neonate Pediatrics Reverse Transcriptase Polymerase Chain Reaction transient abnormal myelopoiesis
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