Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles

A crucial event in female reproduction occurs at midcycle, when a LH peak induces the final maturation of ovarian follicles. LH signals via a G protein-coupled receptor selectively expressed in the outermost follicular cell layers. However, how LH signals are relayed inside these cells and finally t...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2016-04, Vol.157 (4), p.1613-1621
Hauptverfasser:	Lyga, Sandra, Volpe, Silvia, Werthmann, Ruth C, Götz, Konrad, Sungkaworn, Titiwat, Lohse, Martin J, Calebiro, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cyclic AMP - metabolism Endocytosis - physiology Female Fluorescence Resonance Energy Transfer Luteinizing Hormone - pharmacology Meiosis - drug effects Mice, Transgenic Microscopy, Confocal Oocytes - drug effects Oocytes - metabolism Ovarian Follicle - cytology Ovarian Follicle - drug effects Ovarian Follicle - metabolism Receptors, LH - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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