Transgenic expression of human leukocyte antigen‐E attenuates GalKO.hCD46 porcine lung xenograft injury

Background Lung xenografts remain susceptible to loss of vascular barrier function within hours in spite of significant incremental advances based on genetic engineering to remove the Gal 1,3‐αGal antigen (GalTKO) and express human membrane cofactor protein (hCD46). Natural killer cells rapidly disa...

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Veröffentlicht in:	Xenotransplantation (Københaven) 2017-03, Vol.24 (2), p.np-n/a
Hauptverfasser:	Laird, Christopher T., Burdorf, Lars, French, Beth M., Kubicki, Natalia, Cheng, Xiangfei, Braileanu, Gheorghe, Sun, Wenji, O'Neill, Natalie A., Cimeno, Arielle, Parsell, Dawn, So, Edward, Bähr, Andrea, Klymiuk, Nikolai, Phelps, Carol J., Ayares, David, Azimzadeh, Agnes M., Pierson, Richard N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Animals, Genetically Modified Antigens Aorta Cell activation Cell adhesion Cell injury Cytotoxicity Cytotoxicity, Immunologic - immunology Endothelial cells Endothelial Cells - immunology endothelium Galactosyltransferases - genetics Genetic engineering Graft Survival - genetics Graft Survival - immunology Hemodynamics Heterografts - immunology Histamine Histocompatibility antigen HLA HLA Antigens - genetics HLA Antigens - immunology Humans Killer Cells, Natural - immunology Leukocytes - immunology Lung Injury - immunology Lung Injury - therapy lung xenotransplantation Lungs Mechanical stimuli Membrane cofactor protein Membrane Cofactor Protein - genetics Membrane Cofactor Protein - immunology Membrane proteins Microfluidics Natural killer cells Perfusion Pulmonary arteries Pulmonary artery Respiratory function Respiratory tract Swine Transplantation, Heterologous - methods Xenografts
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