Effectiveness and safety of clofazimine in multidrug-resistant tuberculosis: a nationwide report from Brazil

Although clofazimine is used to treat multidrug-resistant tuberculosis (MDR-TB), there is scant information on its effectiveness and safety. The aim of this retrospective, observational study was to evaluate these factors as well as the tolerability of clofazimine in populations in Brazil, where it...

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Veröffentlicht in:	The European respiratory journal 2017-03, Vol.49 (3), p.1602445-1602445
Hauptverfasser:	Dalcolmo, Margareth, Gayoso, Regina, Sotgiu, Giovanni, D'Ambrosio, Lia, Rocha, Jorge L, Borga, Liamar, Fandinho, Fatima, Braga, Jose U, Galesi, Vera M N, Barreira, Draurio, Sanchez, Denise A, Dockhorn, Fernanda, Centis, Rosella, Caminero, Jose A, Migliori, Giovanni B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antitubercular Agents - administration & dosage Antitubercular Agents - adverse effects Body weight Brazil - epidemiology Clofazimine Clofazimine - administration & dosage Clofazimine - adverse effects Drug resistance Drug Therapy, Combination Female Humans Intestine Logistic Models Male Middle Aged Multidrug resistance Multidrug resistant organisms Multivariate Analysis Mycobacterium Mycobacterium tuberculosis - drug effects Neurological complications Pigmentation Pyrazinamide Pyrazinamide - administration & dosage Pyrazinamide - adverse effects Retrospective Studies Safety Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology
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