Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate‐like lymphocytes
Review on developmental signaling pathways in the differentiation and function of innate lymphoid cells and innate‐like lymphocytes. Innate lymphoid cells (ILCs) and innate‐like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors in...
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| Veröffentlicht in: | Journal of leukocyte biology 2017-04, Vol.101 (4), p.827-840 |
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| container_title | Journal of leukocyte biology |
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| creator | Kling, Jessica C. Blumenthal, Antje |
| description | Review on developmental signaling pathways in the differentiation and function of innate lymphoid cells and innate‐like lymphocytes.
Innate lymphoid cells (ILCs) and innate‐like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate‐like lymphocytes. |
| doi_str_mv | 10.1189/jlb.1MR0616-272R |
| format | Article |
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Innate lymphoid cells (ILCs) and innate‐like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate‐like lymphocytes.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.1MR0616-272R</identifier><identifier>PMID: 27733574</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; Autoimmunity ; B1 cell ; Cancer ; Cell Differentiation - immunology ; Differentiation ; Embryogenesis ; Embryonic growth stage ; Hedgehog protein ; Humans ; Immune response ; Immunity, Innate ; innate lymphoid cell ; Lymphocytes ; Lymphocytes - cytology ; Lymphocytes - immunology ; Lymphoid cells ; marginal zone B cell ; Models, Biological ; NK cell ; NKT cell ; Regulators ; Signal transduction ; Signal Transduction - immunology ; Signaling ; Wnt protein ; γδ T cell</subject><ispartof>Journal of leukocyte biology, 2017-04, Vol.101 (4), p.827-840</ispartof><rights>2017 Society for Leukocyte Biology</rights><rights>Society for Leukocyte Biology.</rights><rights>Copyright Federation of American Societies for Experimental Biology (FASEB) Apr 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4067-fa1b4bbaf954416d98374565b1ab6e30a8071b0ed6cbe9b04670105513e74d293</citedby><cites>FETCH-LOGICAL-c4067-fa1b4bbaf954416d98374565b1ab6e30a8071b0ed6cbe9b04670105513e74d293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.1MR0616-272R$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.1MR0616-272R$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27733574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kling, Jessica C.</creatorcontrib><creatorcontrib>Blumenthal, Antje</creatorcontrib><title>Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate‐like lymphocytes</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>Review on developmental signaling pathways in the differentiation and function of innate lymphoid cells and innate‐like lymphocytes.
Innate lymphoid cells (ILCs) and innate‐like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate‐like lymphocytes.</description><subject>Animals</subject><subject>Autoimmunity</subject><subject>B1 cell</subject><subject>Cancer</subject><subject>Cell Differentiation - immunology</subject><subject>Differentiation</subject><subject>Embryogenesis</subject><subject>Embryonic growth stage</subject><subject>Hedgehog protein</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunity, Innate</subject><subject>innate lymphoid cell</subject><subject>Lymphocytes</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphoid cells</subject><subject>marginal zone B cell</subject><subject>Models, Biological</subject><subject>NK cell</subject><subject>NKT cell</subject><subject>Regulators</subject><subject>Signal transduction</subject><subject>Signal Transduction - immunology</subject><subject>Signaling</subject><subject>Wnt protein</subject><subject>γδ T cell</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9uEzEQhy0EomngzglZ4sKhW8brf7tHqIC2Cq0UFXFc2buzicPGTte7qnLrI_CMfZK6SeDABU4ej7752ZqPkDcMThkryg-rzp6yb3NQTGW5zufPyISVvMi40vw5mYAWLJMC4Igcx7gCAJ4reEmOcq05l1pMyN08dBhpaOmPq5sTenV9c3Z-Qo1v6Dk2C1yGBY1u4U3n_II6T4cl0sa1LfboB2cGF_yObkdf7y4pyXlvBty19-XD_a_O_UTabdebZai3A8ZX5EVruoivD-eUfP_yOb2dza6_Xpx9nGW1AKWz1jArrDVtKYVgqikLroVU0jJjFXIwBWhmARtVWywtCKWBgZSMoxZNXvIpeb_P3fThdsQ4VGsXa-w64zGMsUpbZIViolD_gXIpGFMFJPTdX-gqjH3aUqLSFwXnPNFTAnuq7kOMPbbVpndr028rBtWTvyr5qw7-qid_aeTtIXi0a2z-DPwWlgC5B-5ch9t_BlaXs09Q5Jo_Aub3pnk</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Kling, Jessica C.</creator><creator>Blumenthal, Antje</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate‐like lymphocytes</title><author>Kling, Jessica C. ; Blumenthal, Antje</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4067-fa1b4bbaf954416d98374565b1ab6e30a8071b0ed6cbe9b04670105513e74d293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Autoimmunity</topic><topic>B1 cell</topic><topic>Cancer</topic><topic>Cell Differentiation - immunology</topic><topic>Differentiation</topic><topic>Embryogenesis</topic><topic>Embryonic growth stage</topic><topic>Hedgehog protein</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunity, Innate</topic><topic>innate lymphoid cell</topic><topic>Lymphocytes</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphoid cells</topic><topic>marginal zone B cell</topic><topic>Models, Biological</topic><topic>NK cell</topic><topic>NKT cell</topic><topic>Regulators</topic><topic>Signal transduction</topic><topic>Signal Transduction - immunology</topic><topic>Signaling</topic><topic>Wnt protein</topic><topic>γδ T cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kling, Jessica C.</creatorcontrib><creatorcontrib>Blumenthal, Antje</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kling, Jessica C.</au><au>Blumenthal, Antje</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate‐like lymphocytes</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2017-04</date><risdate>2017</risdate><volume>101</volume><issue>4</issue><spage>827</spage><epage>840</epage><pages>827-840</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>Review on developmental signaling pathways in the differentiation and function of innate lymphoid cells and innate‐like lymphocytes.
Innate lymphoid cells (ILCs) and innate‐like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate‐like lymphocytes.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>27733574</pmid><doi>10.1189/jlb.1MR0616-272R</doi><tpages>14</tpages></addata></record> |
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| ispartof | Journal of leukocyte biology, 2017-04, Vol.101 (4), p.827-840 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Autoimmunity B1 cell Cancer Cell Differentiation - immunology Differentiation Embryogenesis Embryonic growth stage Hedgehog protein Humans Immune response Immunity, Innate innate lymphoid cell Lymphocytes Lymphocytes - cytology Lymphocytes - immunology Lymphoid cells marginal zone B cell Models, Biological NK cell NKT cell Regulators Signal transduction Signal Transduction - immunology Signaling Wnt protein γδ T cell |
| title | Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate‐like lymphocytes |
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