Gain of CD26 expression on the malignant T‐cells in relapsed erythrodermic leukemic mycosis fungoides
Loss of CD26 surface expression on the circulating malignant T‐cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T‐cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case o...
Gespeichert in:
| Veröffentlicht in: | Journal of cutaneous pathology 2017-05, Vol.44 (5), p.462-466 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 466 |
|---|---|
| container_issue | 5 |
| container_start_page | 462 |
| container_title | Journal of cutaneous pathology |
| container_volume | 44 |
| creator | Cedeno‐Laurent, Filiberto Wysocka, Maria Obstfeld, Amrom E. Novoa, Roberto A. Vittorio, Carmela C. Kim, Ellen J. Weng, Wen‐Kai Rook, Alain H. |
| description | Loss of CD26 surface expression on the circulating malignant T‐cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T‐cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T‐cells with high CD26 expression. Polymerase chain reaction studies and high‐throughput sequencing analyses from peripheral blood mononuclear cells at presentation and relapse consistently showed an identical clonal T‐cell receptor suggesting evolution of her original malignant clone which lacked CD26 expression. Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL. |
| doi_str_mv | 10.1111/cup.12899 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1891860262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1891860262</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-ea1fbc645784b5fa69ecbeb2629221c5f0195df24c09bda22f23be854a64d34c3</originalsourceid><addsrcrecordid>eNp1kMFOGzEQhi3UClLgwAsgS73QwxLb63XsIwotICGVQzhbXu84cdhdL3ZWkBuP0Gfsk9RpaA-VOpcZjb75NPoROqPkkuaa2nG4pEwqdYAmVBBSkEqQD2hCSlIWQsnZEfqU0poQKqSoDtERk0SWissJWt4Y3-Pg8PyaCQyvQ4SUfMirHm9WgDvT-mVv-g1e_Hz7YaFtE84HEVozJGgwxO1mFUMDsfMWtzA-wW7otjYkn7Ab-2XwDaQT9NGZNsHpez9Gj9--Lua3xf33m7v51X1hy6pUBRjqait4NZO8rpwRCmwNNRNMMUZt5QhVVeMYt0TVjWHMsbIGWXEjeFNyWx6ji713iOF5hLTRnU-7t00PYUyaSkWlIFmY0c__oOswxj5_p6lihAsxozxTX_aUjSGlCE4P0XcmbjUlepe-zunr3-ln9vzdONYdNH_JP3FnYLoHXnwL2_-b9PzxYa_8BamRj7U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1920466714</pqid></control><display><type>article</type><title>Gain of CD26 expression on the malignant T‐cells in relapsed erythrodermic leukemic mycosis fungoides</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Cedeno‐Laurent, Filiberto ; Wysocka, Maria ; Obstfeld, Amrom E. ; Novoa, Roberto A. ; Vittorio, Carmela C. ; Kim, Ellen J. ; Weng, Wen‐Kai ; Rook, Alain H.</creator><creatorcontrib>Cedeno‐Laurent, Filiberto ; Wysocka, Maria ; Obstfeld, Amrom E. ; Novoa, Roberto A. ; Vittorio, Carmela C. ; Kim, Ellen J. ; Weng, Wen‐Kai ; Rook, Alain H.</creatorcontrib><description>Loss of CD26 surface expression on the circulating malignant T‐cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T‐cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T‐cells with high CD26 expression. Polymerase chain reaction studies and high‐throughput sequencing analyses from peripheral blood mononuclear cells at presentation and relapse consistently showed an identical clonal T‐cell receptor suggesting evolution of her original malignant clone which lacked CD26 expression. Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/cup.12899</identifier><identifier>PMID: 28083948</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Biomarkers, Tumor ; CD164 ; CD26 ; CD4 antigen ; CD4-Positive T-Lymphocytes - metabolism ; CD4-Positive T-Lymphocytes - pathology ; CD7 antigen ; clonal evolution ; CTCL ; Dermatitis, Exfoliative - metabolism ; Dermatitis, Exfoliative - pathology ; Dipeptidyl Peptidase 4 - biosynthesis ; Dipeptidyl-peptidase IV ; Female ; Fungal infections ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Leukemic ; Humans ; Immunotherapy ; Leukemia ; Leukemia, T-Cell - metabolism ; Leukemia, T-Cell - pathology ; Leukocytes (mononuclear) ; Lymphocytes T ; Mycosis ; Mycosis fungoides ; Mycosis Fungoides - metabolism ; Mycosis Fungoides - pathology ; Neoplasm Proteins - biosynthesis ; Next-generation sequencing ; Peripheral blood mononuclear cells ; Polymerase chain reaction ; Remission ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; T cell receptors ; T-cell lymphoma</subject><ispartof>Journal of cutaneous pathology, 2017-05, Vol.44 (5), p.462-466</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-ea1fbc645784b5fa69ecbeb2629221c5f0195df24c09bda22f23be854a64d34c3</citedby><cites>FETCH-LOGICAL-c3539-ea1fbc645784b5fa69ecbeb2629221c5f0195df24c09bda22f23be854a64d34c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcup.12899$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcup.12899$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28083948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cedeno‐Laurent, Filiberto</creatorcontrib><creatorcontrib>Wysocka, Maria</creatorcontrib><creatorcontrib>Obstfeld, Amrom E.</creatorcontrib><creatorcontrib>Novoa, Roberto A.</creatorcontrib><creatorcontrib>Vittorio, Carmela C.</creatorcontrib><creatorcontrib>Kim, Ellen J.</creatorcontrib><creatorcontrib>Weng, Wen‐Kai</creatorcontrib><creatorcontrib>Rook, Alain H.</creatorcontrib><title>Gain of CD26 expression on the malignant T‐cells in relapsed erythrodermic leukemic mycosis fungoides</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Loss of CD26 surface expression on the circulating malignant T‐cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T‐cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T‐cells with high CD26 expression. Polymerase chain reaction studies and high‐throughput sequencing analyses from peripheral blood mononuclear cells at presentation and relapse consistently showed an identical clonal T‐cell receptor suggesting evolution of her original malignant clone which lacked CD26 expression. Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL.</description><subject>Aged</subject><subject>Biomarkers, Tumor</subject><subject>CD164</subject><subject>CD26</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>CD7 antigen</subject><subject>clonal evolution</subject><subject>CTCL</subject><subject>Dermatitis, Exfoliative - metabolism</subject><subject>Dermatitis, Exfoliative - pathology</subject><subject>Dipeptidyl Peptidase 4 - biosynthesis</subject><subject>Dipeptidyl-peptidase IV</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Expression Regulation, Leukemic</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Leukemia</subject><subject>Leukemia, T-Cell - metabolism</subject><subject>Leukemia, T-Cell - pathology</subject><subject>Leukocytes (mononuclear)</subject><subject>Lymphocytes T</subject><subject>Mycosis</subject><subject>Mycosis fungoides</subject><subject>Mycosis Fungoides - metabolism</subject><subject>Mycosis Fungoides - pathology</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Next-generation sequencing</subject><subject>Peripheral blood mononuclear cells</subject><subject>Polymerase chain reaction</subject><subject>Remission</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>T cell receptors</subject><subject>T-cell lymphoma</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFOGzEQhi3UClLgwAsgS73QwxLb63XsIwotICGVQzhbXu84cdhdL3ZWkBuP0Gfsk9RpaA-VOpcZjb75NPoROqPkkuaa2nG4pEwqdYAmVBBSkEqQD2hCSlIWQsnZEfqU0poQKqSoDtERk0SWissJWt4Y3-Pg8PyaCQyvQ4SUfMirHm9WgDvT-mVv-g1e_Hz7YaFtE84HEVozJGgwxO1mFUMDsfMWtzA-wW7otjYkn7Ab-2XwDaQT9NGZNsHpez9Gj9--Lua3xf33m7v51X1hy6pUBRjqait4NZO8rpwRCmwNNRNMMUZt5QhVVeMYt0TVjWHMsbIGWXEjeFNyWx6ji713iOF5hLTRnU-7t00PYUyaSkWlIFmY0c__oOswxj5_p6lihAsxozxTX_aUjSGlCE4P0XcmbjUlepe-zunr3-ln9vzdONYdNH_JP3FnYLoHXnwL2_-b9PzxYa_8BamRj7U</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Cedeno‐Laurent, Filiberto</creator><creator>Wysocka, Maria</creator><creator>Obstfeld, Amrom E.</creator><creator>Novoa, Roberto A.</creator><creator>Vittorio, Carmela C.</creator><creator>Kim, Ellen J.</creator><creator>Weng, Wen‐Kai</creator><creator>Rook, Alain H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>201705</creationdate><title>Gain of CD26 expression on the malignant T‐cells in relapsed erythrodermic leukemic mycosis fungoides</title><author>Cedeno‐Laurent, Filiberto ; Wysocka, Maria ; Obstfeld, Amrom E. ; Novoa, Roberto A. ; Vittorio, Carmela C. ; Kim, Ellen J. ; Weng, Wen‐Kai ; Rook, Alain H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-ea1fbc645784b5fa69ecbeb2629221c5f0195df24c09bda22f23be854a64d34c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor</topic><topic>CD164</topic><topic>CD26</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>CD7 antigen</topic><topic>clonal evolution</topic><topic>CTCL</topic><topic>Dermatitis, Exfoliative - metabolism</topic><topic>Dermatitis, Exfoliative - pathology</topic><topic>Dipeptidyl Peptidase 4 - biosynthesis</topic><topic>Dipeptidyl-peptidase IV</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Expression Regulation, Leukemic</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Leukemia</topic><topic>Leukemia, T-Cell - metabolism</topic><topic>Leukemia, T-Cell - pathology</topic><topic>Leukocytes (mononuclear)</topic><topic>Lymphocytes T</topic><topic>Mycosis</topic><topic>Mycosis fungoides</topic><topic>Mycosis Fungoides - metabolism</topic><topic>Mycosis Fungoides - pathology</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Next-generation sequencing</topic><topic>Peripheral blood mononuclear cells</topic><topic>Polymerase chain reaction</topic><topic>Remission</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>T cell receptors</topic><topic>T-cell lymphoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cedeno‐Laurent, Filiberto</creatorcontrib><creatorcontrib>Wysocka, Maria</creatorcontrib><creatorcontrib>Obstfeld, Amrom E.</creatorcontrib><creatorcontrib>Novoa, Roberto A.</creatorcontrib><creatorcontrib>Vittorio, Carmela C.</creatorcontrib><creatorcontrib>Kim, Ellen J.</creatorcontrib><creatorcontrib>Weng, Wen‐Kai</creatorcontrib><creatorcontrib>Rook, Alain H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cedeno‐Laurent, Filiberto</au><au>Wysocka, Maria</au><au>Obstfeld, Amrom E.</au><au>Novoa, Roberto A.</au><au>Vittorio, Carmela C.</au><au>Kim, Ellen J.</au><au>Weng, Wen‐Kai</au><au>Rook, Alain H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gain of CD26 expression on the malignant T‐cells in relapsed erythrodermic leukemic mycosis fungoides</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2017-05</date><risdate>2017</risdate><volume>44</volume><issue>5</issue><spage>462</spage><epage>466</epage><pages>462-466</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><abstract>Loss of CD26 surface expression on the circulating malignant T‐cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T‐cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T‐cells with high CD26 expression. Polymerase chain reaction studies and high‐throughput sequencing analyses from peripheral blood mononuclear cells at presentation and relapse consistently showed an identical clonal T‐cell receptor suggesting evolution of her original malignant clone which lacked CD26 expression. Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>28083948</pmid><doi>10.1111/cup.12899</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-6987 |
| ispartof | Journal of cutaneous pathology, 2017-05, Vol.44 (5), p.462-466 |
| issn | 0303-6987 1600-0560 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1891860262 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biomarkers, Tumor CD164 CD26 CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD7 antigen clonal evolution CTCL Dermatitis, Exfoliative - metabolism Dermatitis, Exfoliative - pathology Dipeptidyl Peptidase 4 - biosynthesis Dipeptidyl-peptidase IV Female Fungal infections Gene Expression Regulation, Enzymologic Gene Expression Regulation, Leukemic Humans Immunotherapy Leukemia Leukemia, T-Cell - metabolism Leukemia, T-Cell - pathology Leukocytes (mononuclear) Lymphocytes T Mycosis Mycosis fungoides Mycosis Fungoides - metabolism Mycosis Fungoides - pathology Neoplasm Proteins - biosynthesis Next-generation sequencing Peripheral blood mononuclear cells Polymerase chain reaction Remission Skin Neoplasms - metabolism Skin Neoplasms - pathology T cell receptors T-cell lymphoma |
| title | Gain of CD26 expression on the malignant T‐cells in relapsed erythrodermic leukemic mycosis fungoides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T03%3A45%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gain%20of%20CD26%20expression%20on%20the%20malignant%20T%E2%80%90cells%20in%20relapsed%20erythrodermic%20leukemic%20mycosis%20fungoides&rft.jtitle=Journal%20of%20cutaneous%20pathology&rft.au=Cedeno%E2%80%90Laurent,%20Filiberto&rft.date=2017-05&rft.volume=44&rft.issue=5&rft.spage=462&rft.epage=466&rft.pages=462-466&rft.issn=0303-6987&rft.eissn=1600-0560&rft_id=info:doi/10.1111/cup.12899&rft_dat=%3Cproquest_cross%3E1891860262%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1920466714&rft_id=info:pmid/28083948&rfr_iscdi=true |