Biological and clinical consequences of NPM1 mutations in AML

Acute myeloid leukemia (AML) is characterized by accumulation of myeloid cells in the bone marrow because of impaired differentiation and proliferation, resulting in hematopoietic insufficiency. NPM1 is one of the most commonly mutated genes in AML, present in 20–30% of cases. Mutations in NPM1 repr...

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Veröffentlicht in:	Leukemia 2017-04, Vol.31 (4), p.798-807
Hauptverfasser:	Heath, E M, Chan, S M, Minden, M D, Murphy, T, Shlush, L I, Schimmer, A D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/68 631/208/737 692/420/755 692/53/2422 692/699/67/1990/283/1897 Acute myelocytic leukemia Acute myeloid leukemia Biomarkers, Tumor Biosynthesis Bone marrow Cancer Research Cell proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Clinical Decision-Making Critical Care Medicine Cytoplasm Diagnosis Epistasis, Genetic Gene expression Gene Expression Regulation, Leukemic Gene Frequency Gene mutation Genetic aspects Hematology Humans Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - therapy Leukemogenesis Localization Medicine Medicine & Public Health Mutation Myeloid cells Neoplasm, Residual - diagnosis Neoplasm, Residual - genetics Neoplasm, Residual - metabolism Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology Phosphorylation Prognosis Protein Binding Protein Interaction Domains and Motifs Protein Processing, Post-Translational Proteins Recurrence review Ribonucleic acid RNA RNA polymerase
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