Synapsins regulate brain‐derived neurotrophic factor‐mediated synaptic potentiation and axon elongation by acting on membrane rafts

In neurons, intracellular membrane rafts are essential for specific actions of brain‐derived neurotrophic factor (BDNF), which include the regulation of axon outgrowth, growth cone turning and synaptic transmission. Virtually, all the actions of BDNF are mediated by binding to its receptor, TrkB. Th...

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Veröffentlicht in:	The European journal of neuroscience 2017-04, Vol.45 (8), p.1085-1101
Hauptverfasser:	Kao, Hung‐Teh, Ryoo, Kanghyun, Lin, Albert, Janoschka, Stephen R., Augustine, George J., Porton, Barbara, Kano, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonogenesis Brain - cytology Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cell Enlargement Cell Line, Tumor Cells, Cultured Cholesterol Cholesterol - metabolism Elongation Fyn protein Growth cones Humans Intracellular lipid Lipid composition Lipid rafts Lipids Localization Membrane Microdomains - metabolism Membrane Potentials - physiology Mice, Inbred C57BL Mice, Knockout mouse Neuroblastoma Neuroblasts neurodevelopment Neuroglia - cytology Neuroglia - metabolism Neurons Neurons - metabolism Neurons - physiology Phospholipids Phospholipids - metabolism Phosphoproteins Potentiation Promotion Protein-tyrosine kinase Proto-Oncogene Proteins c-fyn - metabolism Receptor, trkB - metabolism signal transduction Synapses - metabolism Synapsin Synapsins - genetics Synapsins - metabolism Synaptic transmission Synaptic Transmission - physiology Synaptogenesis TrkB receptors
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